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Database: UniProt
Entry: A0A0C7N5K9_9SACH
LinkDB: A0A0C7N5K9_9SACH
Original site: A0A0C7N5K9_9SACH 
ID   A0A0C7N5K9_9SACH        Unreviewed;      4925 AA.
AC   A0A0C7N5K9;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN   ORFNames=LALA0_S07e05490g {ECO:0000313|EMBL:CEP63233.1};
OS   Lachancea lanzarotensis.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=1245769 {ECO:0000313|EMBL:CEP63233.1, ECO:0000313|Proteomes:UP000054304};
RN   [1] {ECO:0000313|EMBL:CEP63233.1, ECO:0000313|Proteomes:UP000054304}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 12615 {ECO:0000313|EMBL:CEP63233.1,
RC   ECO:0000313|Proteomes:UP000054304};
RA   Neuveglise Cecile;
RL   Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC       of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC       {ECO:0000256|ARBA:ARBA00004642}.
CC   -!- SIMILARITY: Belongs to the midasin family.
CC       {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR   EMBL; LN736366; CEP63233.1; -; Genomic_DNA.
DR   STRING; 1245769.A0A0C7N5K9; -.
DR   HOGENOM; CLU_000050_0_2_1; -.
DR   OrthoDB; 1221059at2759; -.
DR   Proteomes; UP000054304; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IEA:InterPro.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd01460; vWA_midasin; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR040848; AAA_lid_7.
DR   InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR   InterPro; IPR048617; MDN1_AAA_lid_4.
DR   InterPro; IPR012099; Midasin.
DR   InterPro; IPR041190; Midasin_AAA_lid_5.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR   PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR   Pfam; PF07728; AAA_5; 7.
DR   Pfam; PF17865; AAA_lid_5; 1.
DR   Pfam; PF17867; AAA_lid_7; 3.
DR   Pfam; PF21108; MDN1_4th; 1.
DR   PIRSF; PIRSF010340; Midasin; 1.
DR   SMART; SM00382; AAA; 6.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR010340};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR010340};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR010340};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054304}.
FT   DOMAIN          4719..4914
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          4049..4589
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4077..4091
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4100..4116
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4123..4154
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4155..4179
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4209..4239
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4262..4291
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4306..4366
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4391..4409
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4411..4427
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4434..4448
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4453..4515
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4517..4532
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4535..4555
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4556..4583
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4925 AA;  555968 MW;  9990CCBC02F75821 CRC64;
     MLEGQNQLLL SVSLSEKRAH MYNNQFKRKQ ILEYVKIDLE RSVSANLETL AQAALVSQVP
     LAYMFIYRPV LLDLVARWAE SNSQDQLVMV ADRLAQAIAV YPETATLCDH FLQTQHQNLN
     LMLEMGVSQP EPALHGILLA YYRFLQFDRE RFTRFITPST LYKVLQTQFS NHAIKFLAVK
     VLSVYLNMAE QATVDLIEKH APADTEGILA PFDGDNDVDY RFLELNEAQR LSQYQTLLDK
     YNDNQVAVQK KVELDSLVIE PCHLSASIMA IFGVLVPRVN ASAQRYEACS ENRFVPTKKA
     VSFIRELSRC VQHSKPVMLV GKAGSGKTFL VNQLSKYTGA YEKMVKIHLG EQTDAKLLLG
     TYTSGEKPGT FEWRAGVLTT AVKEGRWVLI EDIDKAPTEV LSVLLTLLEQ RQLSIPSRGE
     TIKAANGFQL ISTIRVTDND HRDEKNFKPD LIGIRLWEVV NLTEPDEKEL QQILTHKFSA
     LSHLIGRFIT SYHLVQNVYS NPQFISMNRG VHPRAVTVRD LVKFCSRVEE IFKDNSIKSS
     QELIPSHVYD SIFFEAADCF ACAIGELRAL KPIVETIGVA LEIPASRINL YLSKHVPVFE
     ESKTTLKIGR TILAKNRARL VKKSMNNTSF ARTNHSLRLM EQVGTAIKMC EPVLLVGETG
     TGKTTVVQEM AKALSQKLTV INVSQQTESG DLLGGFKPVN TKTIAIPLLE DFESIFPATF
     SMKKNERFYT MVHKCFNKGQ WKNVIKLLNE AIKLARNILC QDEVESSSDN QKKKRKLNSH
     ENKILLDRWS EFHHSISKFE AQYSSIENSF VFSFVEGSLV KAVRNGEWLL LDELNLASPD
     TLESISDLLS EPTTRSVLLS EKGQAEPVKA HPNFRIFACM NPATDVGKRD LPLGVRSRFT
     EIYVHSPDRD ITDLLAIIDK YIGLFSVSDE WVGNDVAELY LAAKKLAEAN KLVDGSNQKP
     HFSIRTLTRT LIYVRDIVKV YGLRRSLYEG FCMSFLTLLN ENSEALLRPL IEKFTLGRLK
     NPKSVISQSP PCPGTDYVQF KHYWMKKGAH ELQEQPQYII TPFVEKNMLN LVRATSGRRF
     PVLIQGPTSA GKTSMIKYLA DITGHEFVRI NNHEHTDLQE YLGTYMADET GKLSFREGVL
     VDALRKGHWI VLDELNLAPT DVLEALNRLL DDNRELFIPE TQEVIHPHPD FMLFATQNPP
     GIYGGRKVLS RAFRNRFLEL HFDDIPQDEL EIILRERCKI APSYAQKIVE AYRQLSVQRS
     AMRLFEQKNS FATLRDLFRW ALRDAVGYEN LAANGYMLLA ERCRTTEERA LVKRVLEKVM
     KVKLDMDKYY ETLEIEGLQA MQSSVIWTKA MRKLAVLVTT CLKNNEPVLL VGETGCGKTT
     ICQLIARFTG HQLVTLNAHQ NTETGDILGA QRPNRHRSEI QGELLKLLMK VLKFASHSMP
     TMDELLGTYK RADKTFMDPA EVKAIGDLQD KLNVLFEWCD GPLVQALNEG KFFLLDEISL
     ADDSVLERLN SVLEPERNLL LAEKAGPDSL VKAADGFQFF ATMNPGGDYG KKELSPALRN
     RFTEIWVPSM EDFDDVRLIV SSKLKLELSS LVDPIVQFSK WFGERFGGGT TSNGIISLRD
     ILSWIQFVNV SIERLGNEVA ALVQGAAMVF IDTLGTNNTA YLSENAETLK LQRMECLEVL
     GKFYGEDVRP YYLQQPTLVI EDRNVQVGMF ALDRGVSASS PQFNLNAPTT LNNLMRVVRA
     MQVQKPILLE GSPGVGKTSL VSALAESTGN KLTRINLSEQ TDLVDLFGSD APGETTGEFV
     WRDAPFLRAM QLGEWVLLDE MNLASQSVLE GLNACLDHRG EAYIPELDKA FTKHPGFTVF
     AAQNPQNQGG GRKGLPKSFV NRFNVVFVDV LSSEDLFLIA SHLYPEINPN WCTQLIEIIS
     TMEDEVSNRR LWGHAGSPWE FNLRDTLRWL KLLKAPNLTT GAGPVEYLDM ILTQRFRTHE
     DRSRVAKMFE HFFGKKDERP SYFRITAEYL QVNSEIMPRA AFVKHHSLRG LTPLQCNFQV
     YESVLRCVKQ NWPLVLCGPT NSGKSEIIKY VSGVLGAKVS SFPMNSDTDS MDILGGYEQV
     DLNRKIGQTV DRMLTTLREL IAINLGSRLC GDDAKMTALT LFQFITTHSM DTLNLPSLLQ
     LMERIDQFIN NDTISEALAE LQAIRGELDK PSSVTFEWFD GLLLKAMEEG SWLILENANL
     CSPSVLDRLN SLLETDGSLI INECSHEDGR PKVVDPHPDF RLFLTVDPKF GELSRAMRNR
     SIEIYVDDLS TRCSSFDMVN MAGQKSQKAR DTAPAIEKDK PINLEVVPLS RYIMSDNSFA
     SEYGHLHDIS AISTSNLAES IVFITSLSVF PTLTAWETNV CNSRYYREDE FVSKLVMLAQ
     YFNDNGILQS LAKIYDDYEQ LASGLLKDPK CFPRAQSLMP SVNAYVSKCL AHSHPTITTS
     EPAFFFDTLR LLNSFSVALD TTTRRAQHAK LSDLTYVELS AANYQGRAIK KPPQIPIFEV
     LSLLKAHILE SLMSKALFTF PNLCKDYFDL CSIWIGAFET SKNHDNAKLR AYQDLLESWQ
     QESNLESHET QDVLVIAKKL GGALLMDTGR SMTSIWNAFR QVQPSSKHDW ERLEQLLVVS
     RKFDDVADGQ FSDSYALIAQ LRDTIGDLRL SILSGDTSDF DEVLVTLQKG VDQLDTISRR
     FLNPRKHFFK PEFDALLRLV CNEGQKMDYA LNKIASYTSI STETLLSMKQ VSQDRPAVFD
     LLWKKTQGQF ESSTISIFDS STLENVANKA ISFSKVIGSQ LSQALEDALV LRDQLVESSH
     SIVGHQLNLY RNALLEWYRK IVSLHVEVKP KATLGEIQEA LSNYENTWFK NIHEQFLLAG
     AVSALESDTL SSLGKAWVLF SAGALQLFVP STSFDPAIND YVLYDNYMIK QSLSNELLRS
     WECCRVVLSG DKPTAMEELM SEATHNHPPA KPRVYRPQKA IDPLFEEWGA LMKSTIGAEP
     VERLLTSLEG FESLSEGQLN LFQQNSSQFL ERLISNYGVY SDLNEIFRGY VLGLKFGFDL
     VKQGRIDAQK KMNLKPLWTL DLHVLSNPER INDSYAQLQP LFKSFTVESL CVERIANFYL
     KLFSFHGKDV RLGNTFENAL QTMYYRWSMR RLRDEKEAQA KVGVYKFDDV DADVESDFRR
     LFPDYEQVLL VGEEPSSESV NEEGLEDIYY DVAKTYLRTF GDEPPADLPE MISDGCRVSD
     ALKEIGAACK TCSPGPSILI SVLGQLTQEL KSFESQKQVN ELDFYRGFSL YETKRAVAVV
     EKLWISTSNL LAQWPEHSTL NDLFRVCQEF MNYSGNTPIA RLLQKIEQIF TIVTEWEKYA
     SVSVSLHDSV RELTDLVVSW RRLELRTWNS LFDHEHLALN KTMGKWWFYL YETITLTFSE
     EQSGDTNTFD RIAKLLGSLN VFLSKCSYGE FSGRLALLRA FANHAKFSMG QDSNVTQALF
     NLITFFDQFS ATIAEAIKEG RKKLEKEVSD VILLASWKDV NIDALKQSSH RSHNSLYKLV
     RKYRTLLSQN VFSVIESGLQ GSTHRSFQTE GFVASKASDT PSLDINALVV RISSWGDRPA
     FLKNSELSSR KMFSHCSSIE SEEYPQLTAF ADDVSAEVRR LRDETPKVYN KKEKKLLAAL
     RIQKSKLLND SLKELRRMGL KTAFRQDIRK VQESVTSVLS CVQNFEDSPL EKCDSYFFRI
     LELMPRLRFV ISSPAADAPL APIEKGLAVV ENLLYFLITS RKTFHESSNN YVRLKKLYGT
     LEQTSQSTKG LMHGSLVTTF DKFAYMCSWL PKILRYALDT LIMTVSTSES GWLATLLSEG
     IEKTSQFKVA SERPVLDSDS STVLTEFNDF CDDFVDRLST NSSTKTAFIS QVVIDWIAEH
     KVSHYHPDSS TTDVSLENIE NAFRKVSTSI MLTIQQLLES QTERITTEDD NWLLNSHKRI
     TTLSRSVSIS RVSSNVEKAL GLIQSQNFSV DQSQIIVAVV RFTMPMISRY FQFLVSLMNK
     IKSEYHSLSY ATFTLASILY NLGKNGFCSP SPPEEETEDS NLQEGTGLGD GEGAQNSKDV
     EEDEDLLEDA QKPNEDQDKN DSEENSEDDA VDMDGDMAGD LENASGGDDD EGNEENEENE
     DLDEEVDNLD DDDPNAIDEK MWNEEPEDSS KEKQADDAPV NSANDDVQAA ENENGDQSSE
     AKRPEAEDAA DGEEEDESDR DEDHSDADSD EENDAAGQDD EIKNDENGDI DSAVPEVETM
     DLPEDMNLDS GDEDSIDNAS ESEDEEGSGG EKEDDALNNT GMNDKDDEEV GEDDIQGDKD
     DVNMEEEDDD DDDPTNPDEG PANEDENARD DEMEDQNSET ETNPLEEDSA ELLNNQNEEM
     DSREAGGEEG ADENLEGLDG ADDMMNVDND DFDPNVQQES GAQGKGADAV NNQEDENIGD
     SGNAQQEMQE DAGDAPEVSR QEAKDSLKQL GDSLKEFHRR HQEIKEASNN EEVKEEAASA
     NERPDSFEHL DGPNTDHDTQ ALGSADKDQT TTVNDEMAID DEAEDLEEEE NEQTEEALPK
     GEALPEEENA EQMPLEQAHD RDSQGRANGS PLELLEDARQ QKTVTNPEPF EADNNDLDDI
     IDAIDQKVVL DEATAEPPRT LEDARNLWRK SEIETADLAA GLGEQLRLIL EPTLATKLKG
     DYKTGKRLNM KRIIPYIASQ FRKDKIWLKR TKPSKRQYQI MIAVDDSKSM SESKSVDLAF
     QSICLVSKAL TQLESGGLSI VKFGDTTQEV HQFDKPFGND AGAKIFQWFD FQDTRTDVKK
     LVAESIRIFD RGRNLNNADL WQLQIIISDG VCEDHETVQR LVRRARDNKI MLVFVIIDGI
     NTSESIMEMS QVKYVPDSFG NLQLKVERYL DTFPFEFYVL VRDISELPEM LSVILRQYFS
     ELASH
//
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