ID A0A0C7N5K9_9SACH Unreviewed; 4925 AA.
AC A0A0C7N5K9;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=LALA0_S07e05490g {ECO:0000313|EMBL:CEP63233.1};
OS Lachancea lanzarotensis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=1245769 {ECO:0000313|EMBL:CEP63233.1, ECO:0000313|Proteomes:UP000054304};
RN [1] {ECO:0000313|EMBL:CEP63233.1, ECO:0000313|Proteomes:UP000054304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 12615 {ECO:0000313|EMBL:CEP63233.1,
RC ECO:0000313|Proteomes:UP000054304};
RA Neuveglise Cecile;
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR EMBL; LN736366; CEP63233.1; -; Genomic_DNA.
DR STRING; 1245769.A0A0C7N5K9; -.
DR HOGENOM; CLU_000050_0_2_1; -.
DR OrthoDB; 1221059at2759; -.
DR Proteomes; UP000054304; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd01460; vWA_midasin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 7.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 1.
DR SMART; SM00382; AAA; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000054304}.
FT DOMAIN 4719..4914
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 4049..4589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4077..4091
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4100..4116
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4123..4154
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4155..4179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4209..4239
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4262..4291
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4306..4366
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4391..4409
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4411..4427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4434..4448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4453..4515
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4517..4532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4535..4555
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4556..4583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4925 AA; 555968 MW; 9990CCBC02F75821 CRC64;
MLEGQNQLLL SVSLSEKRAH MYNNQFKRKQ ILEYVKIDLE RSVSANLETL AQAALVSQVP
LAYMFIYRPV LLDLVARWAE SNSQDQLVMV ADRLAQAIAV YPETATLCDH FLQTQHQNLN
LMLEMGVSQP EPALHGILLA YYRFLQFDRE RFTRFITPST LYKVLQTQFS NHAIKFLAVK
VLSVYLNMAE QATVDLIEKH APADTEGILA PFDGDNDVDY RFLELNEAQR LSQYQTLLDK
YNDNQVAVQK KVELDSLVIE PCHLSASIMA IFGVLVPRVN ASAQRYEACS ENRFVPTKKA
VSFIRELSRC VQHSKPVMLV GKAGSGKTFL VNQLSKYTGA YEKMVKIHLG EQTDAKLLLG
TYTSGEKPGT FEWRAGVLTT AVKEGRWVLI EDIDKAPTEV LSVLLTLLEQ RQLSIPSRGE
TIKAANGFQL ISTIRVTDND HRDEKNFKPD LIGIRLWEVV NLTEPDEKEL QQILTHKFSA
LSHLIGRFIT SYHLVQNVYS NPQFISMNRG VHPRAVTVRD LVKFCSRVEE IFKDNSIKSS
QELIPSHVYD SIFFEAADCF ACAIGELRAL KPIVETIGVA LEIPASRINL YLSKHVPVFE
ESKTTLKIGR TILAKNRARL VKKSMNNTSF ARTNHSLRLM EQVGTAIKMC EPVLLVGETG
TGKTTVVQEM AKALSQKLTV INVSQQTESG DLLGGFKPVN TKTIAIPLLE DFESIFPATF
SMKKNERFYT MVHKCFNKGQ WKNVIKLLNE AIKLARNILC QDEVESSSDN QKKKRKLNSH
ENKILLDRWS EFHHSISKFE AQYSSIENSF VFSFVEGSLV KAVRNGEWLL LDELNLASPD
TLESISDLLS EPTTRSVLLS EKGQAEPVKA HPNFRIFACM NPATDVGKRD LPLGVRSRFT
EIYVHSPDRD ITDLLAIIDK YIGLFSVSDE WVGNDVAELY LAAKKLAEAN KLVDGSNQKP
HFSIRTLTRT LIYVRDIVKV YGLRRSLYEG FCMSFLTLLN ENSEALLRPL IEKFTLGRLK
NPKSVISQSP PCPGTDYVQF KHYWMKKGAH ELQEQPQYII TPFVEKNMLN LVRATSGRRF
PVLIQGPTSA GKTSMIKYLA DITGHEFVRI NNHEHTDLQE YLGTYMADET GKLSFREGVL
VDALRKGHWI VLDELNLAPT DVLEALNRLL DDNRELFIPE TQEVIHPHPD FMLFATQNPP
GIYGGRKVLS RAFRNRFLEL HFDDIPQDEL EIILRERCKI APSYAQKIVE AYRQLSVQRS
AMRLFEQKNS FATLRDLFRW ALRDAVGYEN LAANGYMLLA ERCRTTEERA LVKRVLEKVM
KVKLDMDKYY ETLEIEGLQA MQSSVIWTKA MRKLAVLVTT CLKNNEPVLL VGETGCGKTT
ICQLIARFTG HQLVTLNAHQ NTETGDILGA QRPNRHRSEI QGELLKLLMK VLKFASHSMP
TMDELLGTYK RADKTFMDPA EVKAIGDLQD KLNVLFEWCD GPLVQALNEG KFFLLDEISL
ADDSVLERLN SVLEPERNLL LAEKAGPDSL VKAADGFQFF ATMNPGGDYG KKELSPALRN
RFTEIWVPSM EDFDDVRLIV SSKLKLELSS LVDPIVQFSK WFGERFGGGT TSNGIISLRD
ILSWIQFVNV SIERLGNEVA ALVQGAAMVF IDTLGTNNTA YLSENAETLK LQRMECLEVL
GKFYGEDVRP YYLQQPTLVI EDRNVQVGMF ALDRGVSASS PQFNLNAPTT LNNLMRVVRA
MQVQKPILLE GSPGVGKTSL VSALAESTGN KLTRINLSEQ TDLVDLFGSD APGETTGEFV
WRDAPFLRAM QLGEWVLLDE MNLASQSVLE GLNACLDHRG EAYIPELDKA FTKHPGFTVF
AAQNPQNQGG GRKGLPKSFV NRFNVVFVDV LSSEDLFLIA SHLYPEINPN WCTQLIEIIS
TMEDEVSNRR LWGHAGSPWE FNLRDTLRWL KLLKAPNLTT GAGPVEYLDM ILTQRFRTHE
DRSRVAKMFE HFFGKKDERP SYFRITAEYL QVNSEIMPRA AFVKHHSLRG LTPLQCNFQV
YESVLRCVKQ NWPLVLCGPT NSGKSEIIKY VSGVLGAKVS SFPMNSDTDS MDILGGYEQV
DLNRKIGQTV DRMLTTLREL IAINLGSRLC GDDAKMTALT LFQFITTHSM DTLNLPSLLQ
LMERIDQFIN NDTISEALAE LQAIRGELDK PSSVTFEWFD GLLLKAMEEG SWLILENANL
CSPSVLDRLN SLLETDGSLI INECSHEDGR PKVVDPHPDF RLFLTVDPKF GELSRAMRNR
SIEIYVDDLS TRCSSFDMVN MAGQKSQKAR DTAPAIEKDK PINLEVVPLS RYIMSDNSFA
SEYGHLHDIS AISTSNLAES IVFITSLSVF PTLTAWETNV CNSRYYREDE FVSKLVMLAQ
YFNDNGILQS LAKIYDDYEQ LASGLLKDPK CFPRAQSLMP SVNAYVSKCL AHSHPTITTS
EPAFFFDTLR LLNSFSVALD TTTRRAQHAK LSDLTYVELS AANYQGRAIK KPPQIPIFEV
LSLLKAHILE SLMSKALFTF PNLCKDYFDL CSIWIGAFET SKNHDNAKLR AYQDLLESWQ
QESNLESHET QDVLVIAKKL GGALLMDTGR SMTSIWNAFR QVQPSSKHDW ERLEQLLVVS
RKFDDVADGQ FSDSYALIAQ LRDTIGDLRL SILSGDTSDF DEVLVTLQKG VDQLDTISRR
FLNPRKHFFK PEFDALLRLV CNEGQKMDYA LNKIASYTSI STETLLSMKQ VSQDRPAVFD
LLWKKTQGQF ESSTISIFDS STLENVANKA ISFSKVIGSQ LSQALEDALV LRDQLVESSH
SIVGHQLNLY RNALLEWYRK IVSLHVEVKP KATLGEIQEA LSNYENTWFK NIHEQFLLAG
AVSALESDTL SSLGKAWVLF SAGALQLFVP STSFDPAIND YVLYDNYMIK QSLSNELLRS
WECCRVVLSG DKPTAMEELM SEATHNHPPA KPRVYRPQKA IDPLFEEWGA LMKSTIGAEP
VERLLTSLEG FESLSEGQLN LFQQNSSQFL ERLISNYGVY SDLNEIFRGY VLGLKFGFDL
VKQGRIDAQK KMNLKPLWTL DLHVLSNPER INDSYAQLQP LFKSFTVESL CVERIANFYL
KLFSFHGKDV RLGNTFENAL QTMYYRWSMR RLRDEKEAQA KVGVYKFDDV DADVESDFRR
LFPDYEQVLL VGEEPSSESV NEEGLEDIYY DVAKTYLRTF GDEPPADLPE MISDGCRVSD
ALKEIGAACK TCSPGPSILI SVLGQLTQEL KSFESQKQVN ELDFYRGFSL YETKRAVAVV
EKLWISTSNL LAQWPEHSTL NDLFRVCQEF MNYSGNTPIA RLLQKIEQIF TIVTEWEKYA
SVSVSLHDSV RELTDLVVSW RRLELRTWNS LFDHEHLALN KTMGKWWFYL YETITLTFSE
EQSGDTNTFD RIAKLLGSLN VFLSKCSYGE FSGRLALLRA FANHAKFSMG QDSNVTQALF
NLITFFDQFS ATIAEAIKEG RKKLEKEVSD VILLASWKDV NIDALKQSSH RSHNSLYKLV
RKYRTLLSQN VFSVIESGLQ GSTHRSFQTE GFVASKASDT PSLDINALVV RISSWGDRPA
FLKNSELSSR KMFSHCSSIE SEEYPQLTAF ADDVSAEVRR LRDETPKVYN KKEKKLLAAL
RIQKSKLLND SLKELRRMGL KTAFRQDIRK VQESVTSVLS CVQNFEDSPL EKCDSYFFRI
LELMPRLRFV ISSPAADAPL APIEKGLAVV ENLLYFLITS RKTFHESSNN YVRLKKLYGT
LEQTSQSTKG LMHGSLVTTF DKFAYMCSWL PKILRYALDT LIMTVSTSES GWLATLLSEG
IEKTSQFKVA SERPVLDSDS STVLTEFNDF CDDFVDRLST NSSTKTAFIS QVVIDWIAEH
KVSHYHPDSS TTDVSLENIE NAFRKVSTSI MLTIQQLLES QTERITTEDD NWLLNSHKRI
TTLSRSVSIS RVSSNVEKAL GLIQSQNFSV DQSQIIVAVV RFTMPMISRY FQFLVSLMNK
IKSEYHSLSY ATFTLASILY NLGKNGFCSP SPPEEETEDS NLQEGTGLGD GEGAQNSKDV
EEDEDLLEDA QKPNEDQDKN DSEENSEDDA VDMDGDMAGD LENASGGDDD EGNEENEENE
DLDEEVDNLD DDDPNAIDEK MWNEEPEDSS KEKQADDAPV NSANDDVQAA ENENGDQSSE
AKRPEAEDAA DGEEEDESDR DEDHSDADSD EENDAAGQDD EIKNDENGDI DSAVPEVETM
DLPEDMNLDS GDEDSIDNAS ESEDEEGSGG EKEDDALNNT GMNDKDDEEV GEDDIQGDKD
DVNMEEEDDD DDDPTNPDEG PANEDENARD DEMEDQNSET ETNPLEEDSA ELLNNQNEEM
DSREAGGEEG ADENLEGLDG ADDMMNVDND DFDPNVQQES GAQGKGADAV NNQEDENIGD
SGNAQQEMQE DAGDAPEVSR QEAKDSLKQL GDSLKEFHRR HQEIKEASNN EEVKEEAASA
NERPDSFEHL DGPNTDHDTQ ALGSADKDQT TTVNDEMAID DEAEDLEEEE NEQTEEALPK
GEALPEEENA EQMPLEQAHD RDSQGRANGS PLELLEDARQ QKTVTNPEPF EADNNDLDDI
IDAIDQKVVL DEATAEPPRT LEDARNLWRK SEIETADLAA GLGEQLRLIL EPTLATKLKG
DYKTGKRLNM KRIIPYIASQ FRKDKIWLKR TKPSKRQYQI MIAVDDSKSM SESKSVDLAF
QSICLVSKAL TQLESGGLSI VKFGDTTQEV HQFDKPFGND AGAKIFQWFD FQDTRTDVKK
LVAESIRIFD RGRNLNNADL WQLQIIISDG VCEDHETVQR LVRRARDNKI MLVFVIIDGI
NTSESIMEMS QVKYVPDSFG NLQLKVERYL DTFPFEFYVL VRDISELPEM LSVILRQYFS
ELASH
//