ID A0A0C7N9C0_9SACH Unreviewed; 4102 AA.
AC A0A0C7N9C0;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=LALA0_S11e05182g {ECO:0000313|EMBL:CEP64483.1};
OS Lachancea lanzarotensis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=1245769 {ECO:0000313|EMBL:CEP64483.1, ECO:0000313|Proteomes:UP000054304};
RN [1] {ECO:0000313|EMBL:CEP64483.1, ECO:0000313|Proteomes:UP000054304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 12615 {ECO:0000313|EMBL:CEP64483.1,
RC ECO:0000313|Proteomes:UP000054304};
RA Neuveglise Cecile;
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; LN736370; CEP64483.1; -; Genomic_DNA.
DR STRING; 1245769.A0A0C7N9C0; -.
DR HOGENOM; CLU_000038_7_0_1; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000054304; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.10.8.740; -; 1.
DR Gene3D; 1.20.1280.160; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054304}.
FT DOMAIN 1789..1962
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2417..2563
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 4102 AA; 466509 MW; B9E0AF0AFC2B699B CRC64;
MSLEEFDNTH LHNVFLDNIA HYCFRVASAH FGITPDAHEF DKFKEINELE IANFVAEDNT
KGLALFLDTD ETILAGLEPP KPPEKGSNDA KMMVIMIKSS PKLDDDRAVE TQLFAISSLH
AMTSAAFSRL MTAGASFIMD YTASSSESTE LDGITLHNIR SKMAAFSELA ESGKSKVVLP
DLLSTVHPLV NRIVTEGATS NNYQQFLDEQ FKDTSTLNIL QNIVMGWTQS LRCLTELTRE
VKAGTLEDEV TFWDSVEKAL VSVSDQTQDL AVQLTIEVLH EARRLQTTFV HLSQTVVAKR
LKEIRAYNLF LGEIPISKLH AVTSLDQLHP LILELNICLK KLKVCAYPVS RAQPLLELLT
EEFLSRLQTV APELSLMDFD YFNITVRTLL ALLKEWDDLV ADQNLLFREI VRRRSEKVKN
IKLDPHTSAL RSRIEEFQGV RRNLQAWKID LLQTGLTKYA TLVNEAYEAF SSISSLVCSN
DTWTAAMDVY KAHSVSFEAK IAGILRFKLN CCQEATEMFA VWESFQPLLS RARLRANLQD
YHQVLFDSIL LDVAKLRNRF SNQLPDNQVS QLMDIPGSSS RVMQNKNIER RIKSLMKKAT
LVFGDEWKNS VEGQPVHEEC KSMLELVQID ASGQTWISTA DYSLDLGDKT VLEIRKDSDR
FSAHVTSNNS YRNSFKEVRN LKWLKFNIPR SVEKLSQSVR RAYPQAIQLS EHLDTFLIVV
NRVGKSSFLK ALFNEQIDQA FTLFGQCMDV KWESLHSVNV VSSSRSSHDL PTKSRTILSK
FRNLSASMIT AYSAAEIPDE LLRAAVNSIS DGPFLEDQLK VKIEVIIRLS ERFTTLTNFG
VRAFVNYLGL KVAKELALVL EEALKTDKLP KQVYSVRVNS GKITISSQLE TVKAKWINYT
QMILDIALQS LETYQDLQKK NGINPGHNLL GYFKRRASFI VGKSLREQDS ILYNALENLK
RWNKYEALWN LADVNILEES ALDLEAVASV YDGLLTDLNE VQVMNTHVEV TQAFTVNLKE
VKFAVQTSLR EWQARLLKVL EKLYVAESKS FHNILSMSRA LLEQEIGPLM MSSLSEYCEL
LSEISKLDQR WDAIETRFST IQSVSEVARG DKGFSRVGAI SLDQLELDVI SLSQVLRKRI
AWLDQIKPSA ISSLDRCFDS LESSSRSLEL DWEQDKAVKD TSSPSAALEA LDLIGALNEK
YLVQLSQVNV LYSILSLPKR PINFLSCASK DIADQKQAWA AIRSDWSTLQ LLLQTNWNDV
KISDVKARIE SFLSQPYGGQ RNVRKNAVLN SFLTQVHSIN HAYKRLQEIK ECQLKARHWS
SLLRDRDNSD DSDKIIDAES LTLNDVLQLV SSCGILEQVL HEARSEAVLE SSLETIESHW
KNTKFKRYQH LAGLMLVKEW KVLFELVEDD LDTLRSMKSS AHYKHFDDLC QNWGRKLNSL
ASIFKDWAEA QRLWLYLQAA LSTRQDSILR SEWSKFEVLS SDFAFLVSRV FESNVASDVL
IVKDFHKLLR SILESLKRIM NSLNNYLDIQ REHFPRLYFL GNEDLLQLMG ASQNLEQASL
SFNKLYMGVS SLCCKGQAIT GVLSREGELL HFETALEIGH YSEMKDWLLE FDSRLKSSVL
EATESCLTQL QAGGLKVLAL TFENCLFQAA LLSLQIWWTT EIEKQLKYME FKTIGEDIDG
VIHHLTSKAQ ATNDDLCRKK AENLIIECIH LKSSLTILKE CDRMTASSVW KDTFKYYYCA
KAPISHRMEI KVGISSFFHG LEYIGVPERL IYTPLLSNCF TAMTHALSQK KGCSPFGPAG
TGKTETVKAL GQNMGRMVLV FNCDDSFDFQ SLGRLLFGIA QLGAWGCFDE FNRMDESIMS
AVSSQIGELQ DALFQKEKRI SVLGKSALLH ENAGVFITMN HGYKGRHNLP DNLKTKFRSF
SMCEPDNNII AKVILLSLGF REANEMSIKI TSFLKILQER CSNQKFYDFG LRAMKSILRN
CKTLRHSMFD TNLEHLLNLS LHQLIEPRLE EQDLLIFRDA LSELFPGLQL QQADQDFFDY
IKAACHQQQL APTNEFSKKC RQFFHIQKSQ HATIISGPSG AGKSSVWKTT LNAMYLMDQI
ENTTYILDPK VLSKSQLYGY LDPVTFEWSD GLFSSILRQI TRDALGTLQS KRIWIVFDGD
LDPDYLETLN SVLDDNRVFT LPNGERFSIP SNLNFIFEVE TLEAATPATI SRCAVIMIGR
ELYDTPDILR KQLFEYVARV NFQASLNVVR EIDFIETILK DFGPLLSRLY SEIQSRSTNW
LIKLTKLIDT FVSLVGSQVL QGMDDLRAVS TQAFNCYLKK TSVICLAWAV SSECSESDRV
FLEAMVKELS PDTTFLNSLD SPLTDLFVSP KDYNLALLST QVPHNSLESY QVLSPDLIIT
TLDTLKHERF VFDLLTSGKS LILCGPPGSG KTMTLNNALK KSKRFELIGL TFSRETSVDT
ICKLLKHHTT VTENATDMVM RPKSMLKDLV LFCDEINLPR TDPHGVQPPI MFLRQILEKR
GFWNTDKCKW VRLERILVVG ACNPADGAAR HVISERFMRL TPVLSVQYPG PDSLRHIYVT
LFDATFKLVP NLRDYATDFA EASLDLYRTC CQKFLSRDNS LYVLSPRDLT RWVKGIHHIL
ANSSVQNLSE LIEIWLYEGS RLFEDRLVEA ASKKEYQIAA RGAISKFFPG QQTPDPEVDI
LITNWLTTEY KKTSRRDITA FVRERLSTFA DEELECSLIP TASLVNHMVR VDRVLKQEQG
HCIIAGPDRS AKRSLVRFVS WLNGMEVVQL VVHRSFDISD FDKILKSLMV KCSIENRKVV
LMVDDSSRLD PGFIERMNTL LANSDIPGLF EGQERLKLIS DLSTRADKSG LLYDNNDELY
AWFTTLIAHN LHVVFTINSA ESHSATNIMS SPALLNRCVL DFMEEWSDET FSQIGDEILQ
WMPLEQDYRG EQLQNPLSSK RVMSDTIVES AVELFKHYQG LKIEPLSYGR YFDHLLMFQR
IYSERSSELE SLQYFMSSGL ESIKQSALSV KELSVELSEK KKMLEQKEIE ARRSLDKMLV
TQNEAERKHE ASIEIRKILE VQEKDLTSQR ARIQNDLALV EPEILEAQRG VTNIKKQHMT
EIRSMINPPK NVKLTLEAVC IILGHGSKEW RDIQNYIRKD EFISNIVHYD TSKMMDDSTR
SYVEDEYVSR PGFTYETVKY ASQACGPLFQ WVLAQVKYAS MLTTVSPLKE HILMVERDIL
QTKARLLAAE DMIVDYQKIT EESKSEYSSM IRDIEIIKSE LKQVQQKVLR SQKVLKSLVA
ENSRWSSSIA KFNDNKSRVV GDSFLSATYL SYCMRHDTLV RHAFLSHSKK LLSMKKIPYD
ENYNFSDHCV KFEEKSKWLE EDLPDDELCV ENFYAILKLQ QYSFVIDPES VAASSITKHF
GVNLIVTSFL DSGFVKKLKN ALRFGSTILI EDGDYFDPII SALIAQEFKT IGGRKTIKIG
EELVDVSSAF RLLISSKNAA CPISGFVKTR MSVVNFVIDK FSLQAQSVEL TLRHEKSELC
RERLELRQLN GNYKLKLRSL EKDLLNALSG SNSDLLGNDV LLSVLEQVKN SASEVQAKVE
ETRGVLDAIE KAATEYEIVG SHAMGIYAVM EKLSSLHWSY QISIKSFLRC SASIFDNMEE
PVKQGRPQQL LSTLYQKIFQ FFSPSMTDEH KIVLATLLFA RYLELNFNST LHCEFKNLLS
SISTNTEFSA ETPDEIYLST PKSDVALTYV KSLRDSVNNN CVFSQLSGTL SNFEGTSSMG
LEQYIDADFD VPMLILLEEG ADVTSRISQL AALRSLKLLT ISLGSLESTA MADSALTDCI
QTGQWLLLQN LQMSPDWVKS VLTRSLDSLM NEPYISPNFR LFLTCDLEST NIPPPLLKKT
WHLVQGRKRG ILATAQDVWS TLAHHSSIIE KKSPAQLFCY VLLAWFHALL VEYSSLHPLG
FTKNYEFNDA DFSSAVFYMD RLFEAIEDHN TIPWKNICFN ISTIIYGGKI DNDRDLKLCI
GVGSRLFTPD ALKTNFEIVP GLLAPPEKDA YEWSDYKQWL LQCPAPDSWS DWLGLGNDLE
KEQQNFQAQK IAGSILTVLD NC
//
