ID A0A0C9LU46_9FUNG Unreviewed; 811 AA.
AC A0A0C9LU46;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Mismatch repair endonuclease PMS2-like {ECO:0000313|EMBL:GAN04390.1};
GN ORFNames=MAM1_0062d03850 {ECO:0000313|EMBL:GAN04390.1};
OS Mucor ambiguus.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=91626 {ECO:0000313|EMBL:GAN04390.1};
RN [1] {ECO:0000313|EMBL:GAN04390.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NBRC 6742 {ECO:0000313|EMBL:GAN04390.1};
RA Takeda I., Yamane N., Morita T., Tamano K., Machida M., Baker S., Koike H.;
RT "Draft genome sequence of an oleaginous Mucoromycotina fungus Mucor
RT ambiguus NBRC6742.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; DF836351; GAN04390.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C9LU46; -.
DR STRING; 91626.A0A0C9LU46; -.
DR OrthoDB; 4698638at2759; -.
DR Proteomes; UP000053815; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Endonuclease {ECO:0000313|EMBL:GAN04390.1};
KW Hydrolase {ECO:0000313|EMBL:GAN04390.1};
KW Nuclease {ECO:0000313|EMBL:GAN04390.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053815}.
FT DOMAIN 217..340
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 612..751
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 355..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 811 AA; 88649 MW; 70B1502473CA871B CRC64;
MSVISAIDKS SVHKICSGQV VLDIATAVKE LVENSIDAGA TSVDVNFIDS GIGGIEVVDN
GCGIDPLNYE SLALKHYTSK ISSFEDLEKV MTFGFRGEAL SSLCALSHLT VITATKTQAP
MGVKLEYDIA GSLKSKTPQS RTAGTTLQLT DIFHSLPVRR QEFKRNIKRE FGKALVILQA
YSVISTNVKI TVSNQTGTKP SIKIMSTSKN KKMSDNITNI FGSKLTSQII PFKVDLGSAL
EGGCVEGFIS KPEWGLGRST SDRQYFYVNG RPCVLPKIAK AINEVYRIFI TNQYPVVIAN
LKLPTDAYDV NVSPDKRTIY LHEENKISDA LQEQLKDQME PSRSIFNVNS LMSLKKPADE
PSTSKTDIRA ETDISTPTST FTTSAGSLPR PSPRVVSLSS FARGATKSTP SSSSSSKRPN
PSAATSSLMN YMTKKPRVDI VTAAGDDIVM EASGQDTSML VDVSSGTPSR ATEMEVDELD
DSSDEAGVDA EPSSKASDSN GQEPEQFDDA TKESVLDSDS REYIQTISNI SSFKGLWKTV
GRTKSVTPID LATLRKSQPA VIMHNEAPGP QSVQPPVQVL QNASVKNTDD NEKATRALSR
VISKPDFARM EVLGQFNLGF MITALDGQDL PTTDKASDMA PLGVFFHSNL TAYSSPILDL
TAAEELTVMD NLDIFKANGF DVEILPDNPP TTRIRVVSQP VSKNTMFDKR DFSELIHLIT
EHPGEMVRCS RNRAMFASRA CHKAARIGDS LSKNQMTKIV RHMGEIDQPW NCPHGRPTMR
HLFNISQFKE EYKANVSSRP LQFSGTLFHT K
//
