ID A0A0C9LUR1_9FUNG Unreviewed; 842 AA.
AC A0A0C9LUR1;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Alpha-ketoglutarate-dependent dioxygenase alkb-like {ECO:0000313|EMBL:GAN05465.1};
GN ORFNames=MAM1_0092c04936 {ECO:0000313|EMBL:GAN05465.1};
OS Mucor ambiguus.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=91626 {ECO:0000313|EMBL:GAN05465.1};
RN [1] {ECO:0000313|EMBL:GAN05465.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NBRC 6742 {ECO:0000313|EMBL:GAN05465.1};
RA Takeda I., Yamane N., Morita T., Tamano K., Machida M., Baker S., Koike H.;
RT "Draft genome sequence of an oleaginous Mucoromycotina fungus Mucor
RT ambiguus NBRC6742.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|PIRSR:PIRSR604574-2};
CC Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604574-2};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the YIP1 family.
CC {ECO:0000256|ARBA:ARBA00010596}.
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DR EMBL; DF836381; GAN05465.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C9LUR1; -.
DR OrthoDB; 47845at2759; -.
DR Proteomes; UP000053815; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR InterPro; IPR004574; Alkb.
DR InterPro; IPR027450; AlkB-like.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR006977; Yip1_dom.
DR PANTHER; PTHR16557; ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED; 1.
DR PANTHER; PTHR16557:SF2; NUCLEIC ACID DIOXYGENASE ALKBH1; 1.
DR Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR Pfam; PF04893; Yip1; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
PE 3: Inferred from homology;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964, ECO:0000313|EMBL:GAN05465.1};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Iron {ECO:0000256|PIRSR:PIRSR604574-2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR604574-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000053815};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 122..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 106..266
FT /note="Yip1"
FT /evidence="ECO:0000259|Pfam:PF04893"
FT DOMAIN 497..676
FT /note="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"
FT /evidence="ECO:0000259|Pfam:PF13532"
FT REGION 444..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 577
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
FT BINDING 579
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
FT BINDING 633
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
SQ SEQUENCE 842 AA; 93824 MW; 965695C2740F7F2A CRC64;
MSNKYNVLVD MEDAAYSQPA TIESDGLEFQ DFSSQTKSSF NHAPPPAAAA ATATSSNTGF
FDSPQQQRST INGKPIWSVE YYAQFFDVDT TQVIDRCVKS MYPVGDYAAD TLQNQPDLYG
PFWIATSVVF SVFVCSSLAG SLAAYIAGKP HVYDFTLLSF AVVVVYMYAF LCPALVWAST
KYFGCQPSLL EIINYYGYGL TIWIPVSLLC IIPFDYARWA FVGVAFVVTA VFLVKNLYIV
ISRADAKTSR IILLAILLAH TIFALVLKMA FYSYDFRPDI WERQRKEAEA KKKTSTSYVN
QAPFRYAERN FKSRVPPPDF SKVVDFEKTQ DHSDIIVSVQ LTDDLRRLSS VFGQCEAPCR
DAYVLKNVPG LIVIPNAFTP AAQRGLIKQC LSVYPKPPNT SNLDTHYIIP DTGIWPLYEA
QEKGSLKPMD PGYYVPKKVV VENTNSTYSD GDDEEEGGKE PPKMAPTACS DDFQPVIDDP
KPDPLPAPGV PLLSPSELMR KMRWITLGYQ YHWPTKTYHL DRRYPFPADV ADLTKAVVTA
VENIGHDGWI NQYKGEDFNA EAGVINYYQY RDTLMGHVDR SEMNMEAPLV SLSLGQSCIY
LIGGSTRDTV PVPLLLRSGD IVVMTGPCRK AFHGVPLIME NTLPDYLSNK NQYDDAPDWK
LFGDFMSTSR INLNIRQVDC NILRWLLAVD KSKTNDIKCG EEIRFSWRSI PQAFINPWPS
DVVVRAKEGR APRISGQRKH SVSSEGLALY VLTCNHSMLR GLKQLVMGSS RGYAGKVVDP
CGLISIRCSG SLICKVWRLV CLGSAASSFG LLKFQAGIII IPQVCIGVSA TMSRLVSDSN
SR
//
