ID   A0A0C9LVS7_9FUNG        Unreviewed;       311 AA.
AC   A0A0C9LVS7;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=NADPH-dependent D-xylose reductase {ECO:0000313|EMBL:GAN07295.1};
GN   ORFNames=MAM1_0155d06791 {ECO:0000313|EMBL:GAN07295.1};
OS   Mucor ambiguus.
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX   NCBI_TaxID=91626 {ECO:0000313|EMBL:GAN07295.1};
RN   [1] {ECO:0000313|EMBL:GAN07295.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NBRC 6742 {ECO:0000313|EMBL:GAN07295.1};
RA   Takeda I., Yamane N., Morita T., Tamano K., Machida M., Baker S., Koike H.;
RT   "Draft genome sequence of an oleaginous Mucoromycotina fungus Mucor
RT   ambiguus NBRC6742.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DF836444; GAN07295.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0C9LVS7; -.
DR   STRING; 91626.A0A0C9LVS7; -.
DR   OrthoDB; 5305445at2759; -.
DR   Proteomes; UP000053815; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd19071; AKR_AKR1-5-like; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR   PANTHER; PTHR11732:SF507; ALDO_KET_RED DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053815}.
FT   DOMAIN          18..278
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        51
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         109
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            76
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   311 AA;  35134 MW;  9F20A16106B2AC93 CRC64;
     MSDSRVFRLN TGADIPTVGL GTWRSKPEEV YDAVKTAIEA GYRHIDAAFV YGNEKQVGQA
     IKDSNVPREE LFITTKLWNT CHRPELVQAA FERSLENLQL EYLDLYLMHW PVSFQPADVK
     QPRGEDGVIL LDDTHFTTTY AEMEKLLGSK LRAIGVSNFD IPHLEKLATT AKVPPAVNQV
     ELHPYLPQQE LVDYCQKHQI LLCAYSPLGS SDSPLMKDET IIAIANKYNA TAAQILIAWG
     IKRGYAVLPK SVTSSRIISN LKDVRLEIQD FENINKLIQN HPTRRLGDPY LSWDVDVFGL
     HPGEEKVKYS I
//