ID A0A0C9M5V5_9FUNG Unreviewed; 2677 AA.
AC A0A0C9M5V5;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Neurofibromin {ECO:0000313|EMBL:GAN05041.1};
GN ORFNames=MAM1_0080d04510 {ECO:0000313|EMBL:GAN05041.1};
OS Mucor ambiguus.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=91626 {ECO:0000313|EMBL:GAN05041.1};
RN [1] {ECO:0000313|EMBL:GAN05041.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NBRC 6742 {ECO:0000313|EMBL:GAN05041.1};
RA Takeda I., Yamane N., Morita T., Tamano K., Machida M., Baker S., Koike H.;
RT "Draft genome sequence of an oleaginous Mucoromycotina fungus Mucor
RT ambiguus NBRC6742.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DF836369; GAN05041.1; -; Genomic_DNA.
DR STRING; 91626.A0A0C9M5V5; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000053815; Unassembled WGS sequence.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053815};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1300..1515
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1670..1826
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 102..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 906..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..869
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2677 AA; 300400 MW; 4B05388D6C485DC1 CRC64;
MSTDTKLILS LVNRIAVRLP SNNGTQFDAL ESDPLIQQTL PTIATTIVTV IENVSKSPLS
RNDDIVPRDV LQSQLFLLRM LSACMQHHWK YCQDLDTKIR SRKQHQDGTE SPIRPSLNRV
DGATPQHSMW SPPQGIPAVP IDPPPLEDNL AKHIVHVMSR FIYQIGILDE KEYGIVANHS
ASACFTETCT NFNGQTLSLS LMVDIYRAAS RVVAYVSASN WSITFAKIKN RILYLTTTQE
ETPEVTDVML LECASLNCKR LSMVLTELCS SALHLRKAAQ LFIAVMLRRA IWNWIENYTA
EFTLLCHNQT RIDGSPEILF DIFNSLADTT KRKAIFWPVQ TMLLVLCPDI MISQSLSGGR
VQNKKSAFFG SLRKAMKGDR MGELAAICYV DLCRAATYVS KDDMTAIRQV VPDVENELID
KLFDIHRPAD VDSLSTSLGV YIDHRSLMAD CIVAMFRLDT QKTIQSLIPT CFDHGAPTIF
KLSVVKAAVA IASEENNLPW IPSISELYLP LCTRIRKLFL EFFTRDFREK SSADAVAAGS
SSISSRKTLT NNLVDKRSNR KDGRTAAQER FELILDVLRL YQTDPKLAIQ GRVEDRFDQN
AALMVAITNC LRDPSACVRD AAAECLYKLH APDNIILWGL PDKFMESFWK ISSQVLFTLA
KQLLDSRERE SGLRKLLDLL KRLLTLRNKF LEQHRDVAIF GIDTRERLQA SIGLEVALLV
LLCSYDTDIC ALSIDCFGLL CTEVHLTERL DDPQPSSITI VENMACYTEL TNHSGVVTGR
KSQQRRIRRL LRMINHSSPG MLAAWEEAWK RWKFMTPLIA RTPDDNVKDD GSFYESSNSS
RRGGGSTWHD KLRNTSSRQL MTPTSSSTRL DMIDDDRSSE WQNYAGFLAA LGGVCLMTEP
SSYSVTTTSS SSIPPSPSSS IRSSRPNNNS AIDSISYSKH ISAPIESANM VDKFIMDMVD
LLACDNLIVR EWVREILGND LSPALYHIMF RHLENTLTKC FGPDNSNDPM CGPRYTLFVE
QAISVLKQVL DRLSEKTDNL FTVDFSTLIN QYALYLNKLG TNQLSIKIKI KMCQLVEVLM
SKKDSVTLRQ EFRLRNKLLE IIVEWTSDFS LKPDNASQSS NYEANQVEKL QSDLDIACLK
TIVALLHHLP LQPSEPVVES DALVIKSRIF YKYFTYFFKL LNRCRVSEIE QSQTRSYDSQ
FRTGSELAPL KNYTILALSN LLSANVDAGL KYSFSMGYHE DTRTRSAFME VLTNILNQGT
EFETLAETVM TDRYEKLIDM LVQDDLRIVL SLCEVCPSSD IDDVANALLA CFASRNKTMT
LLKAVIEREV ETTGIVMINA MLHDTLLTQS KTENETDLFR KTSIATRLLS VYAKNNGADY
VRSVLLPVFQ KLSERPREDK CFELDPSKIG PDEDVSKNRN NVIEATEMFL NAICDSVGDA
PRSFREICHY ILTSVREQFP EAKYTAVGSF IFLRFFCPAI VSPETEGLVK NTASISREMR
RGFLIATKVI QNLANNVLFG AKETYMIVLN DFLTSNIYKV ASFLREISKI PALENTAHAA
DKAGATTTAA TDDVAEVPPM DDKLYAMLHR VLADNIERIS RDVASRHLGG GDQDQNSISA
SKREFDKFAN LLAQLGRPPE VPQKESVGTR SYVYAASNQL YADFMRRNSH RSVESIVSKN
IFYEGGVSKA GRPVFYLIMR HIHADNIDFE LLIYHVLQTL ERASNRHYEL LIDLTRFCRM
NEIPGQWVHQ LMQILSEDKS DNIAVCHIYN PNTYLRTFIK KLARPLSHKF TKRILFAVTL
AELHEHILPS EVRLPKSTTG LETDPSAVFF PVNKILKYTT HLPVTVKVSA EYVQIMTVRK
QEIFYGLNAV TNDICHISEI EDIATTHHER SSLDSSQDFS YNKRRYEMSR PTTISERTIQ
PNDVPGRLLN MALLNLGSDD PNLRLSSYNL LYALSRVFNF DVGKQLLDAK DLCLPANSTE
FIVNISEKIA ATEPSLTMEF LNECVLGYGK SEKGLRYLCL LYMIPWLPNL SLYCNRSPQD
IAKTKELLRL LIDLTLAGDM SKLIQAKIWK TIAKVDDILS LVIDTFILVS NEHGVGSIQA
EALADTLVTL SNVTVRSKLT SYLRKIIHRT SFKPTRSLTD HPSWPEIAIL VRFILMLSFN
NRGPVKRVVP ELFHIVSLIA GVGSTVVRAS VHGVVVNMIQ SLCTSMPLSA ANVKKLQLLL
IELSESKSRL LFGLTRSNTN AFTITPETLN DTIEPISLLS LESIVSKLSE VINYAAPSTD
IANFWRARWM SLVASTAFQF NPAVQPRAFV VLGYLGREEI DDDLLYQILV ALRGALAIFN
DSDPHLVTSI MMCLKNVVES LPGDSRYLLQ LFWVAVALVE INTGPTFAMA VELLQAVVRA
LDSSGFFSGD TMIDVLLAAR EPIADVARQL DNLCGVNFDS HFSFAIAGIF MKGLRYNDVK
DAIYHGLHTF LDIERKQFPH DGLSEESSII ETSTLGYVTG LLPLAAKNDT VKDLLKMAGL
TETDIDSHVL NGKTYAGIFD KLDIPDNTTA LLLISLLANM LNAADNESER LFIYGLLSEA
AIAIPEVFSL VYDSLLPKMN QIVISSQTQP IIESVKSILL TACSDPVFNE SKNKPSQRVL
LDQLGFSSLG DPTFGASSSN VFQNAKLASE LMERIIS
//
