ID A0A0C9M7U1_9FUNG Unreviewed; 601 AA.
AC A0A0C9M7U1;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Creatinase/aminopeptidase {ECO:0000313|EMBL:GAN03129.1};
GN ORFNames=MAM1_0034d02580 {ECO:0000313|EMBL:GAN03129.1};
OS Mucor ambiguus.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=91626 {ECO:0000313|EMBL:GAN03129.1};
RN [1] {ECO:0000313|EMBL:GAN03129.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NBRC 6742 {ECO:0000313|EMBL:GAN03129.1};
RA Takeda I., Yamane N., Morita T., Tamano K., Machida M., Baker S., Koike H.;
RT "Draft genome sequence of an oleaginous Mucoromycotina fungus Mucor
RT ambiguus NBRC6742.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766, ECO:0000256|RuleBase:RU000590}.
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DR EMBL; DF836323; GAN03129.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C9M7U1; -.
DR STRING; 91626.A0A0C9M7U1; -.
DR OrthoDB; 869at2759; -.
DR Proteomes; UP000053815; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:GAN03129.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000590}; Protease {ECO:0000313|EMBL:GAN03129.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053815}.
FT DOMAIN 8..141
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 311..528
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 540..601
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 601 AA; 66691 MW; 40F6AEC4B2CF6011 CRC64;
MPTATSDRLA SLRSQMKEHQ VDAFLAPSED AHQSEYIADC DKRRHWISGF TGSAGFAIVT
STEAALFTDG RYFLQASQQL DDNWTLMKQG LPGVPTWQEY LVKNLPAGSR IGLDPTLINA
VDAHQLNVQL EPLGSSLVPI HENLIDLAWG KDRPESPKDK VFVQPVQFTG KSVHDKLEEL
RTHIKSKNAY GTVVSALDEI AWLFNLRGSD IECNPVFFSY AIVNENEAIL YLDLDKLTDE
VKSHLGSAVT TKPYSQFFAD LKALTLEGKK LLVNNKTSLA VEVAVGETNV LEERSFITDA
KAIKTKEELQ GMRDCHLRDG AALVHYFAWL EKKLLDGEKL SEVEAADRLE QFRAVQDHYV
GLSFATISST GSNGAIIHYK PEPETCKIID PDNIYLCDSG GQYKDGTTDV TRTFHFKTPS
AYEKRCFTRV LQGHIAIDEA VFPKGTTGYL LDPFARQHLW KDGLNFLHGT GHGVGSFLNV
HEGPHGIGIR PHFNDTALAA GMTVTDEPGY YEDGKFGIRI ENVILVKDIE TPNNFGGRGY
LGFEHVTIAP IGLNLIDVDL LSPSEIKWVN AYHEECLAKL GPLVAHDELA TAWLKKETLP
I
//
