ID   A0A0C9MGT6_9FUNG        Unreviewed;       934 AA.
AC   A0A0C9MGT6;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=mRNA m(6)A methyltransferase {ECO:0000256|ARBA:ARBA00012160};
DE            EC=2.1.1.348 {ECO:0000256|ARBA:ARBA00012160};
GN   ORFNames=MAM1_0127d06013 {ECO:0000313|EMBL:GAN06529.1};
OS   Mucor ambiguus.
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX   NCBI_TaxID=91626 {ECO:0000313|EMBL:GAN06529.1};
RN   [1] {ECO:0000313|EMBL:GAN06529.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NBRC 6742 {ECO:0000313|EMBL:GAN06529.1};
RA   Takeda I., Yamane N., Morita T., Tamano K., Machida M., Baker S., Koike H.;
RT   "Draft genome sequence of an oleaginous Mucoromycotina fungus Mucor
RT   ambiguus NBRC6742.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-
CC         methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:55584, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=2.1.1.348;
CC         Evidence={ECO:0000256|ARBA:ARBA00036277};
CC   -!- SIMILARITY: Belongs to the MT-A70-like family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00489}.
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DR   EMBL; DF836416; GAN06529.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0C9MGT6; -.
DR   STRING; 91626.A0A0C9MGT6; -.
DR   OrthoDB; 1357820at2759; -.
DR   Proteomes; UP000053815; Unassembled WGS sequence.
DR   GO; GO:0090304; P:nucleic acid metabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR006342; FkbM_mtfrase.
DR   InterPro; IPR007757; MT-A70-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; TIGR01444; fkbM_fam; 1.
DR   PANTHER; PTHR12829; N6-ADENOSINE-METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR12829:SF2; N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT; 1.
DR   Pfam; PF05050; Methyltransf_21; 1.
DR   Pfam; PF05063; MT-A70; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 3.
DR   PROSITE; PS51143; MT_A70; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053815};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          610..789
FT                   /note="Methyltransferase FkbM"
FT                   /evidence="ECO:0000259|Pfam:PF05050"
FT   REGION          439..472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          487..510
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        450..471
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   934 AA;  106440 MW;  D5ADC6D97AB92F10 CRC64;
     MSERPKRKRR QATALAASTH ARVSNAHYVG YVEDNESVEA IMKKFEELER IQQEFTSSPQ
     LVSNTPPAKP EQDGCVQDTL IEDPLTQEQL EEVFRRTSAF TVKSASLDPN FVVDMDALDL
     LQAEYRNNDT NEFVEEDDYY YVGDDFDLNE QVDDKDGQYR DRDYRRSTPS KKKRLDRQSV
     LNKHKILAAQ AKDETGRIVT AKKQVCSIDP SLPTYVKIPP RPIKASWAHF IKPLSEIIPP
     THYTYHEVKN LVDQDLTQYG SQFQAIYMDP PLLMAGEAPT PGKINIDDLA KLNVPDVIET
     GFLFIWSEKE WLHRIVKIAT QWGFRYVENY CWVKKNINNT IYKGESNYFC KSKLNLLIFK
     KEKSKIEIRH QRNADCLFDF VKPMVAGQFT EPKPSYVYHV IETLLPKSVQ ESRLLKLWST
     RNYRRLGWTT VAEVTKDNVG AFEPPPFNPN TGADSHPPPP PPPPPPAQPN IGISPIAEAK
     LAEHVGINPQ PLDEPDTHYP DTHAKSSQDL DTIAPTADKT TYRLAPEGLK YAQSGDLWQF
     GVINTKPDVF IVSNTNYPDV NNHYHREFRI YTLMKWILRV HRRDPERTAP LVMVDAGSNH
     GLFSLVAGAS GAHTIAFEPQ THLRSVINMA GRLNQLSQRL RVLPFAVLDQ FKKLAMEKVE
     INDGGIGGLS YDNPNALITT QTIRLDTLPA YNRLFPQSTA MEKQLKINTD RKDDKSILEP
     EDLGAEYAKE IEAASDNASA EIPESLLFRQ PIHFLKIDVE GFELPALRSA AKLFENQLVE
     NTVLEFGPPS RWDVTVPDAN HMDLKDVRAK TMKEAKEVLH RAVDEWGLDI NLLPAEGWEK
     TVKFMIDHGI DLSGGNPSKN KVVQRVNAWK FDDLPLDHDE FEKELEIKEN VVTEFIRLPA
     RLIDDYLEAS QAIGEMYLWF TKKDTQSPVL QKIT
//