ID A0A0C9MK27_9FUNG Unreviewed; 729 AA.
AC A0A0C9MK27;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Methionine synthase reductase {ECO:0000256|ARBA:ARBA00040659};
DE EC=1.16.1.8 {ECO:0000256|ARBA:ARBA00039088};
GN ORFNames=MAM1_0176d07288 {ECO:0000313|EMBL:GAN07784.1};
OS Mucor ambiguus.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=91626 {ECO:0000313|EMBL:GAN07784.1};
RN [1] {ECO:0000313|EMBL:GAN07784.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NBRC 6742 {ECO:0000313|EMBL:GAN07784.1};
RA Takeda I., Yamane N., Morita T., Tamano K., Machida M., Baker S., Koike H.;
RT "Draft genome sequence of an oleaginous Mucoromycotina fungus Mucor
RT ambiguus NBRC6742.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
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DR EMBL; DF836465; GAN07784.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C9MK27; -.
DR STRING; 91626.A0A0C9MK27; -.
DR OrthoDB; 9164at2759; -.
DR Proteomes; UP000053815; Unassembled WGS sequence.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR19384:SF84; METHIONINE SYNTHASE REDUCTASE; 1.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00369; FLAVODOXIN.
DR PRINTS; PR00371; FPNCR.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643};
KW Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000053815}.
FT DOMAIN 8..149
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 303..556
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 729 AA; 81807 MW; 8131C7832E74BC31 CRC64;
MADLASEYLI LWASQTGNAE WIAKNIHTEA GKKGYKGECF VMDEFAVAPL QKAGVIIMVS
SNTGDGDSPD NSLKFWRFLR RNKDKSYFSN TRFTILGLGD SNYSNFNNSG KKLEKKFKDL
GGQVFYEKGL ADDAEGLENV VDPWIEKLWE VLPTVLKQEG NESIESSIAH EKELEKEMSE
LAIDPVDVPY SMRNRKKDLP DLAEKYTNLE NTLVDNFTME ARREKLPGKV ADYTNLENTL
VDDIKRTFKS GFPLTISLAG LEAGAKLTGL PRVSVPVAKV TKLEGQKAED FSGKVPDFVS
TPVPITYAPV TMVSCLTAPD AVKRTLEVEL DVGEDNHFEP GDAFGVLAPN DEELVEAILN
RLNIPEEEFH HLYKVEGENL PTHLQKATSA SLIELFRYAV DLTSHPRKAL FRMLADHTTD
PKEKLTLMYI CSKQGAAAFN AIRDETPTLL DILETFPSCH PPIDRLLDLL PAHMPRFYSI
SSSPLKRQGK IRFAFNVVEY ITAGKAERKG VATPWMDKIT KLIPSRSTPT NVEVAVKEDI
KVPMYIRQNA NAFVLPQETE RPLVLIGPGT GIAPFIGFLE HRQTQRNIRL SMGGIGHQPT
QQIRDQFGPI YVYYGFRDKN KDFLFEKEIR EFEKDGTISL LRIAESRAAD GPKVYVQDLI
KEDSSKLYDL IVNKDAAIYI CGDAKGMAKG VQDALAEMLA EHEKIDLLEA NKTLVNWISS
KKYLRDLWA
//
