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Database: UniProt
Entry: A0A0C9MUR6_SPHPI
LinkDB: A0A0C9MUR6_SPHPI
Original site: A0A0C9MUR6_SPHPI 
ID   A0A0C9MUR6_SPHPI        Unreviewed;       375 AA.
AC   A0A0C9MUR6;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=proton-translocating NAD(P)(+) transhydrogenase {ECO:0000256|ARBA:ARBA00012943};
DE            EC=7.1.1.1 {ECO:0000256|ARBA:ARBA00012943};
GN   Name=pntAA {ECO:0000313|EMBL:GAN14426.1};
GN   ORFNames=SP6_39_00010 {ECO:0000313|EMBL:GAN14426.1};
OS   Sphingomonas paucimobilis NBRC 13935.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingomonas.
OX   NCBI_TaxID=1219050 {ECO:0000313|EMBL:GAN14426.1, ECO:0000313|Proteomes:UP000032025};
RN   [1] {ECO:0000313|EMBL:GAN14426.1, ECO:0000313|Proteomes:UP000032025}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 13935 {ECO:0000313|EMBL:GAN14426.1,
RC   ECO:0000313|Proteomes:UP000032025};
RA   Hosoyama A., Hashimoto M., Hosoyama Y., Noguchi M., Uohara A., Ohji S.,
RA   Katano-Makiyama Y., Ichikawa N., Kimura A., Yamazoe A., Fujita N.;
RT   "Whole genome shotgun sequence of Sphingomonas paucimobilis NBRC 13935.";
RL   Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The transhydrogenation between NADH and NADP is coupled to
CC       respiration and ATP hydrolysis and functions as a proton pump across
CC       the membrane. {ECO:0000256|ARBA:ARBA00003943}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+);
CC         Xref=Rhea:RHEA:47992, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:57945, ChEBI:CHEBI:58349; EC=7.1.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000006};
CC   -!- SIMILARITY: Belongs to the AlaDH/PNT family.
CC       {ECO:0000256|ARBA:ARBA00005689}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAN14426.1}.
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DR   EMBL; BBJS01000039; GAN14426.1; -; Genomic_DNA.
DR   RefSeq; WP_007407166.1; NZ_BBJS01000039.1.
DR   AlphaFoldDB; A0A0C9MUR6; -.
DR   GeneID; 78527848; -.
DR   Proteomes; UP000032025; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd05304; Rubrum_tdh; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR008143; Ala_DH/PNT_CS2.
DR   InterPro; IPR007886; AlaDH/PNT_N.
DR   InterPro; IPR007698; AlaDH/PNT_NAD(H)-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR10160; NAD(P) TRANSHYDROGENASE; 1.
DR   PANTHER; PTHR10160:SF19; PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE; 1.
DR   Pfam; PF01262; AlaDh_PNT_C; 1.
DR   Pfam; PF05222; AlaDh_PNT_N; 1.
DR   SMART; SM01002; AlaDh_PNT_C; 1.
DR   SMART; SM01003; AlaDh_PNT_N; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00837; ALADH_PNT_2; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967}.
FT   DOMAIN          6..140
FT                   /note="Alanine dehydrogenase/pyridine nucleotide
FT                   transhydrogenase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01003"
FT   DOMAIN          149..315
FT                   /note="Alanine dehydrogenase/pyridine nucleotide
FT                   transhydrogenase NAD(H)-binding"
FT                   /evidence="ECO:0000259|SMART:SM01002"
SQ   SEQUENCE   375 AA;  38690 MW;  470739C3C0D2F7B4 CRC64;
     MPSRIAVLLE SAQAERRVAA TPETVRKLIA LGATVAIESG AGREAGIADG EYEQAGATVA
     DRATVLAGAD IVLAVQAPDP ATLAGSVPGA WVVAAFDPFR QRERVTGYAA AGLEALAMDW
     MPRITRAQSM DILSSQSNLA GYKAVLEAAS AYGRAFPMMM TAAGTIPAAR VFVMGVGVAG
     LQAIATARRL GAQVSATDVR SATREQIQSL GAKPIFVEGV AGIEGEGAGG YAGETSEEYR
     AAQAELVAGH IAKQDIVITT ALIPGRPAPR LVSDAQIATM RPGSVIVDLA VEAGGNVEGA
     VLGEVVQRHG VTIVGHRNMP SLLAADASAL FARNLYNFLA AFWDKEAARP VLDAEIGDAI
     RLTKGSQVVN PRLSA
//
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