ID A0A0C9SWZ5_PLICR Unreviewed; 595 AA.
AC A0A0C9SWZ5;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Eukaryotic translation initiation factor 2D {ECO:0000256|ARBA:ARBA00013816};
DE AltName: Full=Ligatin {ECO:0000256|ARBA:ARBA00030186};
GN ORFNames=PLICRDRAFT_57876 {ECO:0000313|EMBL:KII84045.1};
OS Plicaturopsis crispa FD-325 SS-3.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Amylocorticiales; Amylocorticiaceae; Plicaturopsis.
OX NCBI_TaxID=944288 {ECO:0000313|EMBL:KII84045.1, ECO:0000313|Proteomes:UP000053263};
RN [1] {ECO:0000313|EMBL:KII84045.1, ECO:0000313|Proteomes:UP000053263}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FD-325 SS-3 {ECO:0000313|EMBL:KII84045.1,
RC ECO:0000313|Proteomes:UP000053263};
RG DOE Joint Genome Institute;
RG Mycorrhizal Genomics Consortium;
RA Kohler A., Kuo A., Nagy L.G., Floudas D., Copeland A., Barry K.W.,
RA Cichocki N., Veneault-Fourrey C., LaButti K., Lindquist E.A., Lipzen A.,
RA Lundell T., Morin E., Murat C., Riley R., Ohm R., Sun H., Tunlid A.,
RA Henrissat B., Grigoriev I.V., Hibbett D.S., Martin F.;
RT "Evolutionary Origins and Diversification of the Mycorrhizal Mutualists.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation initiation factor that is able to deliver tRNA to
CC the P-site of the eukaryotic ribosome in a GTP-independent manner. The
CC binding of Met-tRNA(I) occurs after the AUG codon finds its position in
CC the P-site of 40S ribosomes, the situation that takes place during
CC initiation complex formation on some specific RNAs. Its activity in
CC tRNA binding with 40S subunits does not require the presence of the
CC aminoacyl moiety. Possesses the unique ability to deliver non-Met
CC (elongator) tRNAs into the P-site of the 40S subunit. In addition to
CC its role in initiation, can promote release of deacylated tRNA and mRNA
CC from recycled 40S subunits following ABCE1-mediated dissociation of
CC post-termination ribosomal complexes into subunits.
CC {ECO:0000256|ARBA:ARBA00025522}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the eIF2D family.
CC {ECO:0000256|ARBA:ARBA00010359}.
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DR EMBL; KN832572; KII84045.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C9SWZ5; -.
DR HOGENOM; CLU_012487_1_1_1; -.
DR OrthoDB; 102595at2759; -.
DR Proteomes; UP000053263; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:InterPro.
DR GO; GO:0001731; P:formation of translation preinitiation complex; IEA:InterPro.
DR CDD; cd11608; eIF2D_C; 1.
DR CDD; cd11610; eIF2D_N; 1.
DR CDD; cd21156; PUA_eIF2d-like; 1.
DR Gene3D; 3.10.400.20; -; 1.
DR Gene3D; 3.30.780.10; SUI1-like domain; 1.
DR InterPro; IPR039757; EIF2D.
DR InterPro; IPR048247; eIF2D_N.
DR InterPro; IPR039759; eIF2D_SUI1.
DR InterPro; IPR041366; Pre-PUA.
DR InterPro; IPR002478; PUA.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR048248; PUA_eIF2d-like.
DR InterPro; IPR001950; SUI1.
DR InterPro; IPR036877; SUI1_dom_sf.
DR InterPro; IPR036885; SWIB_MDM2_dom_sf.
DR InterPro; IPR003121; SWIB_MDM2_domain.
DR PANTHER; PTHR12217; EUKARYOTIC TRANSLATION INITIATION FACTOR 2D; 1.
DR PANTHER; PTHR12217:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 2D; 1.
DR Pfam; PF17832; Pre-PUA; 1.
DR Pfam; PF01472; PUA; 1.
DR Pfam; PF01253; SUI1; 1.
DR SUPFAM; SSF55159; eIF1-like; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR SUPFAM; SSF47592; SWIB/MDM2 domain; 1.
DR PROSITE; PS50890; PUA; 1.
DR PROSITE; PS50296; SUI1; 1.
DR PROSITE; PS51925; SWIB_MDM2; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000053263}.
FT DOMAIN 389..480
FT /note="DM2"
FT /evidence="ECO:0000259|PROSITE:PS51925"
FT DOMAIN 505..578
FT /note="SUI1"
FT /evidence="ECO:0000259|PROSITE:PS50296"
FT REGION 209..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 595 AA; 63898 MW; 603E88D755F590EB CRC64;
MFKKPLAHLK TSAPLRSSDR RKLKQRALQT FAIPAEEGDA LVPDGLLAVK FSTHLDEPGV
AYLSPDGDPL WFTLGIGKEA EDLIPTVYTL WKRPTLLPFL STPSAVIPVL VGGADLMIPG
VVECAPDLSP GRLVSITQYA GPGKRGPPLA VGRMVVSSGE LIGDEGGGIE GEGRKGKAVR
VLHTWKDHLW EVGKGGDVPE VVVVNDGQVD GGEASAEGER GPGEGGGVEE SGESANGVLS
GEAQSPPLSP QEVSTILRTS LLQALSTTLS ALPHSALPLP APAFYSTYIL PARPYHPPPS
ASSTPIDIKH SAFKSLSAFL KSTEKDGLLK LKETKADGLV VVGVSPKHAE VAGHRGYVTI
KDIETKRERA EKREKERERE GKGEMEVTEL WKPWQGSVAF FDGVGKETTK LYAHPELKSI
LNEYITAQHL VNPREQQYVN VDALLRSFLV AKSKPKPGAE PEPPLEFIKR EEILAKLLER
MQPWHEIRVD AKEPSSPKKG ALKPISVVTK IRQGRKASTL IAGFEPFGLE ANFLAEELRH
ACASATSVSP IAGKGSALEV LVQGKQIKAV TELLASQGVP RKWVAAADLG DGKKR
//
