ID A0A0D0EF03_9FLAO Unreviewed; 437 AA.
AC A0A0D0EF03;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN ORFNames=IW18_08055 {ECO:0000313|EMBL:KIO53254.1};
OS Flavobacterium hibernum.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=37752 {ECO:0000313|EMBL:KIO53254.1, ECO:0000313|Proteomes:UP000032061};
RN [1] {ECO:0000313|EMBL:KIO53254.1, ECO:0000313|Proteomes:UP000032061}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12611 {ECO:0000313|EMBL:KIO53254.1,
RC ECO:0000313|Proteomes:UP000032061};
RA Stropko S.J., Pipes S.E., Newman J.D.;
RT "Genome of Flavobacterium hibernum DSM 12611.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938,
CC ECO:0000256|RuleBase:RU003423};
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317, ECO:0000256|RuleBase:RU003423}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIO53254.1}.
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DR EMBL; JPRK01000007; KIO53254.1; -; Genomic_DNA.
DR RefSeq; WP_041517082.1; NZ_UGGR01000003.1.
DR AlphaFoldDB; A0A0D0EF03; -.
DR STRING; 37752.IW18_08055; -.
DR OrthoDB; 9805770at2; -.
DR Proteomes; UP000032061; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd06849; lipoyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 1.
DR InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02817; E3_binding; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00189; LIPOYL; 1.
DR PROSITE; PS51826; PSBD; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003423};
KW Lipoyl {ECO:0000256|ARBA:ARBA00022823, ECO:0000256|RuleBase:RU003423};
KW Transferase {ECO:0000256|RuleBase:RU003423}.
FT DOMAIN 3..78
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 124..164
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
SQ SEQUENCE 437 AA; 47286 MW; 5F04DDF46B033373 CRC64;
MARFELKLPK MGESVAEATI TNWLKEVGDK IEADEAVLEI ATDKVDSEVP SEVSGILVEQ
LFGKDDLVQV GQTIAIIETE GDSPVAKASE ETVVSVEVAE IEKTIETTKE TIAAPQDFSG
SDKFFSPLVK NIAKEEGISV AELEVMQGSG KDGRVTKEDI LKYIEDRKSG VVETPKVAAV
TPKVAEPVVQ KSQQAVPVSV NGGDEIIEMD RMRKLISGYM TASVQTSAHV QSFIEVDVTN
IVKWREKVKT AFEKREGEKL TFTPIMMEAV AKALKDFPGM NISVDGDYII KKKNINLGMA
AALPNGNLIV PVIKNADQLN LVGMAKAVND LGNRAKAGKL KPDDTQGGTY TVTNVGTFGS
VFGTPIINQP QVGILALGAI RKVPAVIETP EGDFIGIRQK MFLSHSYDHR VVDGALGGSF
VKRVAEYLEA FDVDRDF
//
