ID A0A0D0EXL9_9FLAO Unreviewed; 426 AA.
AC A0A0D0EXL9;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Argininosuccinate lyase {ECO:0000256|ARBA:ARBA00012338, ECO:0000256|HAMAP-Rule:MF_00006};
DE Short=ASAL {ECO:0000256|HAMAP-Rule:MF_00006};
DE EC=4.3.2.1 {ECO:0000256|ARBA:ARBA00012338, ECO:0000256|HAMAP-Rule:MF_00006};
DE AltName: Full=Arginosuccinase {ECO:0000256|HAMAP-Rule:MF_00006};
GN Name=argH {ECO:0000256|HAMAP-Rule:MF_00006};
GN ORFNames=IW18_15185 {ECO:0000313|EMBL:KIO51961.1};
OS Flavobacterium hibernum.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=37752 {ECO:0000313|EMBL:KIO51961.1, ECO:0000313|Proteomes:UP000032061};
RN [1] {ECO:0000313|EMBL:KIO51961.1, ECO:0000313|Proteomes:UP000032061}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12611 {ECO:0000313|EMBL:KIO51961.1,
RC ECO:0000313|Proteomes:UP000032061};
RA Stropko S.J., Pipes S.E., Newman J.D.;
RT "Genome of Flavobacterium hibernum DSM 12611.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000985, ECO:0000256|HAMAP-
CC Rule:MF_00006};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 3/3.
CC {ECO:0000256|ARBA:ARBA00004941, ECO:0000256|HAMAP-Rule:MF_00006}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00006}.
CC -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_00006}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIO51961.1}.
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DR EMBL; JPRK01000012; KIO51961.1; -; Genomic_DNA.
DR RefSeq; WP_041518741.1; NZ_UGGR01000001.1.
DR AlphaFoldDB; A0A0D0EXL9; -.
DR STRING; 37752.IW18_15185; -.
DR OrthoDB; 9769623at2; -.
DR UniPathway; UPA00068; UER00114.
DR Proteomes; UP000032061; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR HAMAP; MF_00006; Arg_succ_lyase; 1.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR NCBIfam; TIGR00838; argH; 1.
DR PANTHER; PTHR43814; ARGININOSUCCINATE LYASE; 1.
DR PANTHER; PTHR43814:SF1; ARGININOSUCCINATE LYASE; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00145; ARGSUCLYASE.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00006};
KW Arginine biosynthesis {ECO:0000256|ARBA:ARBA00022571, ECO:0000256|HAMAP-
KW Rule:MF_00006}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00006};
KW Lyase {ECO:0000256|HAMAP-Rule:MF_00006, ECO:0000313|EMBL:KIO51961.1}.
FT DOMAIN 9..300
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
SQ SEQUENCE 426 AA; 47314 MW; DDBBB7FAA7A8FC2A CRC64;
MKLWEKGIPT DKQIEHFTVG NDRELDLVLA KYDALGSIAH AKMLGQIGLL TQEETTSLVD
ALNEIIADVA KGNFEIEDSF EDVHSKIEYL LTVKLGDAGK KIHTARSRND QVLVDVHLYL
KDELKALKEQ VKTLFDLLME SAEKHQNVLL PGYTHLQIAM PSSFGMWFSA YAESLIDDVT
MLNAASKIVD QNPLGSAAGY GSSFPINRTF TTQELGFETL KFNAVAAQMS RGKAEKTVAF
AMASVAGTLS KFAMDVCLYM SQNFDFIGLP AHLTTGSSIM PHKKNPDVFE LIRGKCNKIQ
ALPYEITLIT NNLPSGYHRD LQLLKEGLFP ALQNLKACLD IAIFSVKDIT VKDNILKDKK
YDYLFTVDTL NEMVVAGMPF RDAYKAVAEQ LEAGTYQSPK ETKHTHEGSI NNLCLDAIKD
KMKAAF
//
