ID A0A0D0JM03_9NOCA Unreviewed; 183 AA.
AC A0A0D0JM03;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Diadenosine tetraphosphate hydrolase {ECO:0000313|EMBL:KIQ13496.1};
GN ORFNames=RU01_17930 {ECO:0000313|EMBL:KIQ13496.1};
OS Rhodococcus sp. MEB064.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=1587522 {ECO:0000313|EMBL:KIQ13496.1, ECO:0000313|Proteomes:UP000032087};
RN [1] {ECO:0000313|EMBL:KIQ13496.1, ECO:0000313|Proteomes:UP000032087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MEB064 {ECO:0000313|EMBL:KIQ13496.1,
RC ECO:0000313|Proteomes:UP000032087};
RA Perisin M.A., Vetter M., Gilbert J.A., Bergelson J.;
RT "16Stimator: statistical estimation of ribosomal gene copy numbers from
RT draft genome assemblies.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIQ13496.1}.
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DR EMBL; JXQS01000045; KIQ13496.1; -; Genomic_DNA.
DR RefSeq; WP_042575949.1; NZ_JXQS01000045.1.
DR AlphaFoldDB; A0A0D0JM03; -.
DR Proteomes; UP000032087; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR CDD; cd01275; FHIT; 1.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR InterPro; IPR039383; FHIT.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR PANTHER; PTHR42997:SF1; AP-4-A PHOSPHORYLASE; 1.
DR PANTHER; PTHR42997; HIT FAMILY HYDROLASE; 1.
DR Pfam; PF01230; HIT; 1.
DR SUPFAM; SSF54197; HIT-like; 1.
DR PROSITE; PS51084; HIT_2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:KIQ13496.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 47..156
FT /note="HIT"
FT /evidence="ECO:0000259|PROSITE:PS51084"
FT MOTIF 141..145
FT /note="Histidine triad motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00464"
FT ACT_SITE 143
FT /note="Tele-AMP-histidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-1"
FT BINDING 73
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT BINDING 145
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
SQ SEQUENCE 183 AA; 20207 MW; 0C6EA018B7A688F2 CRC64;
MSTEDTDGAI VDTGAGDADR LQRLWSPHRM TYIATAPKTD DKMASEPFTQ IPTLDDEDGL
IVARGEHVYA VLNLYPYNPG HLMVVPYRRV ADLEELTAEE SLELMQFTQH AIRTIKRVSR
PHGFNVGLNL GAPAGGSLAE HLHQHVVPRW GGDANFITVI GGAKIMPQLL RDTRALLADA
WKD
//
