ID A0A0D0JQ43_9MICO Unreviewed; 332 AA.
AC A0A0D0JQ43;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=dTDP-glucose 4,6-dehydratase {ECO:0000256|ARBA:ARBA00016977, ECO:0000256|RuleBase:RU004473};
DE EC=4.2.1.46 {ECO:0000256|ARBA:ARBA00011990, ECO:0000256|RuleBase:RU004473};
GN ORFNames=RU09_16615 {ECO:0000313|EMBL:KIP88389.1};
OS Microbacterium sp. MEJ108Y.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=1587523 {ECO:0000313|EMBL:KIP88389.1, ECO:0000313|Proteomes:UP000032119};
RN [1] {ECO:0000313|EMBL:KIP88389.1, ECO:0000313|Proteomes:UP000032119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MEJ108Y {ECO:0000313|EMBL:KIP88389.1,
RC ECO:0000313|Proteomes:UP000032119};
RA Perisin M.A., Vetter M., Gilbert J.A., Bergelson J.;
RT "16Stimator: statistical estimation of ribosomal gene copy numbers from
RT draft genome assemblies.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose
CC + H2O; Xref=Rhea:RHEA:17221, ChEBI:CHEBI:15377, ChEBI:CHEBI:57477,
CC ChEBI:CHEBI:57649; EC=4.2.1.46;
CC Evidence={ECO:0000256|ARBA:ARBA00001539,
CC ECO:0000256|RuleBase:RU004473};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911,
CC ECO:0000256|RuleBase:RU004473};
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. dTDP-glucose dehydratase subfamily.
CC {ECO:0000256|ARBA:ARBA00008178, ECO:0000256|RuleBase:RU004473}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIP88389.1}.
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DR EMBL; JXQX01000038; KIP88389.1; -; Genomic_DNA.
DR RefSeq; WP_042541952.1; NZ_JXQX01000038.1.
DR AlphaFoldDB; A0A0D0JQ43; -.
DR OrthoDB; 9801785at2; -.
DR Proteomes; UP000032119; Unassembled WGS sequence.
DR GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro.
DR CDD; cd05246; dTDP_GD_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR01181; dTDP_gluc_dehyt; 1.
DR PANTHER; PTHR43000:SF7; DTDP-D-GLUCOSE 4,6-DEHYDRATASE; 1.
DR PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|RuleBase:RU004473}; NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 5..302
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
SQ SEQUENCE 332 AA; 37083 MW; 7AB3BEE4E9AA50E8 CRC64;
MSNILVTGGA GFIGSNFVHY AVEHTDHTVT VLDALTYAGN RASLAGLPDD RVRFVHGDIT
DAELVDRLTA EADAVVHYAA ESHNDNSLHS PRPFLDTNII GTYTLLEAAR KHETRFHHIS
TDEVYGDLEL DDPERFTEQT PYNPSSPYSS TKAGSDLLVR AWVRSFGVQA TISNCSNNYG
PYQHVEKFIP RQITNVIRGI RPKLYGAGEN VRDWIHANDH SSAVLTILEK GQIGETYLIG
ADGERNNKDV VELILEEMGQ PRDAYDHVTD RAGHDLRYAI DSTKLRTELG WKPEFADFES
GLAATIAWYR DNESWWAPSK DQTEAFYASK GQ
//
