ID A0A0D0K3H4_9MICO Unreviewed; 840 AA.
AC A0A0D0K3H4;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=RU09_05050 {ECO:0000313|EMBL:KIP93806.1};
OS Microbacterium sp. MEJ108Y.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=1587523 {ECO:0000313|EMBL:KIP93806.1, ECO:0000313|Proteomes:UP000032119};
RN [1] {ECO:0000313|EMBL:KIP93806.1, ECO:0000313|Proteomes:UP000032119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MEJ108Y {ECO:0000313|EMBL:KIP93806.1,
RC ECO:0000313|Proteomes:UP000032119};
RA Perisin M.A., Vetter M., Gilbert J.A., Bergelson J.;
RT "16Stimator: statistical estimation of ribosomal gene copy numbers from
RT draft genome assemblies.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIP93806.1}.
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DR EMBL; JXQX01000009; KIP93806.1; -; Genomic_DNA.
DR RefSeq; WP_042538336.1; NZ_JXQX01000009.1.
DR AlphaFoldDB; A0A0D0K3H4; -.
DR OrthoDB; 9806130at2; -.
DR Proteomes; UP000032119; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KIP93806.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 618..830
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 840 AA; 88205 MW; 8EB02590C56963E5 CRC64;
MPRRGRLRVL LGAAPGVGKT FEMLVEGRRL LDEGRDVVIA IVETHERAAT AAQTIGIPEV
PRRTDLHRGV PLSEMDLQAV LARHPEIALV DELAHTNTPG SQNAKRWQDV DALLDAGIDV
VTTVNVQHIE SLNAVVEKIT GIAQQETIPD AVVRAADEIE VVDLAPQSLR DRLSAGLVYP
AERIDAALSN YFRLGNLTAL RELALLWLAD EVDSALRSYR ADHGIEGTWQ ARERVVVALT
GGPEGETLLR RGARIAARSA GGELLAVHIA AQDGLRDETP GALAAQRSLV ESLGGSFHQI
IGDDIPGTLV EFAHGADATQ LVIGVSRRGR LAAALTGPGI GSEVIRRSGD IDVHIVTHAA
AGGRAALPRI TGGALGWRRQ LLGFVIALIV GPLLSWAMFA FRSPESITVE VLAFQLLVVI
VALVGGLRPA VFAAVLSGIT LDFLFVSPIF TITIAHPLHV LALALYVIIA ILVSIIVDQA
ARRARTAQRA AAEAELLAAV AGNVLRGDNA VLAMVSRTRE AFGLTGVRLL TAEGEVLASD
GEPVPDGRAT SIPVGAGGSS PAVLELHGEP LDTPARRLLD AIVAQLAAAI EHTDLRATAR
EVAALAETDQ VRSALLSAVS HDLRRPLASA VAAIGGLRGA HRLSASDREE LLATADESLA
TLSSLVTDLL DVSRVQAGVL AVSSMRLDVA GPVLAAVDEL GLGPDDVELA LDADLPAVSA
DPVLLQRVLV NVIANAHRHS PADSRVIVST STLGERAEIR VIDRGKGVPA ENRDRIFQPF
QRLGDTDNTT GLGLGLALSR GFAEGMGGTL TPEDTPGGGL TMVISLPLAG EPDLTQEETE
//
