ID A0A0D0LW50_9FLAO Unreviewed; 324 AA.
AC A0A0D0LW50;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Hydroxyacid dehydrogenase {ECO:0000313|EMBL:KIQ22804.1};
GN ORFNames=RT99_06875 {ECO:0000313|EMBL:KIQ22804.1};
OS Flavobacterium sp. MEB061.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=1587524 {ECO:0000313|EMBL:KIQ22804.1, ECO:0000313|Proteomes:UP000032091};
RN [1] {ECO:0000313|EMBL:KIQ22804.1, ECO:0000313|Proteomes:UP000032091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MEB061 {ECO:0000313|EMBL:KIQ22804.1,
RC ECO:0000313|Proteomes:UP000032091};
RA Perisin M.A., Vetter M., Gilbert J.A., Bergelson J.;
RT "16Stimator: statistical estimation of ribosomal gene copy numbers from
RT draft genome assemblies.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIQ22804.1}.
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DR EMBL; JXQR01000014; KIQ22804.1; -; Genomic_DNA.
DR RefSeq; WP_042563979.1; NZ_JXQR01000014.1.
DR AlphaFoldDB; A0A0D0LW50; -.
DR OrthoDB; 9777288at2; -.
DR Proteomes; UP000032091; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05301; GDH; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719}.
FT DOMAIN 4..319
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 109..287
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 324 AA; 36108 MW; 38E7ECE758A6DC25 CRC64;
MNVFINKNIP EAGIVLLRER GINLTINPTE NVLSRDEFIK ICQENDALLN VGTNNFDEDF
FQQCPNLKGI ALFSVGFDAV NISSANSRKI PVGNTPDVLS RATSDIAFLL MQSVARKSFY
NHKKIINGEW GSFNPLANLG QELYGKTLGI FGLGRIGFEM AQKCKAAFGM NIIYHNRSHN
ENAENELNTE LVDFETLLAK SDVLSVHSNY TEENNELFNK SAFAKMKPSS IFINTARGKF
HNEDDLFHAL TNNIIWGAGL DVTNPEPMKK DNPLLSLPNC CILPHIGSAT YEARNAMAVC
AAQNIIALFE NKKMPFCVNE DVYF
//
