ID A0A0D0N8Z3_KITGR Unreviewed; 2116 AA.
AC A0A0D0N8Z3;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=DEAD/DEAH box helicase {ECO:0000313|EMBL:KIQ64675.1};
GN ORFNames=TR51_10710 {ECO:0000313|EMBL:KIQ64675.1};
OS Kitasatospora griseola (Streptomyces griseolosporeus).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Kitasatospora.
OX NCBI_TaxID=2064 {ECO:0000313|EMBL:KIQ64675.1, ECO:0000313|Proteomes:UP000032066};
RN [1] {ECO:0000313|EMBL:KIQ64675.1, ECO:0000313|Proteomes:UP000032066}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MF730-N6 {ECO:0000313|EMBL:KIQ64675.1,
RC ECO:0000313|Proteomes:UP000032066};
RA Arens J.C., Haltli B., Kerr R.G.;
RT "Draft genome sequence of Kitasatospora griseola MF730-N6, a bafilomycin,
RT terpentecin and satosporin producer.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIQ64675.1}.
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DR EMBL; JXZB01000002; KIQ64675.1; -; Genomic_DNA.
DR RefSeq; WP_043910419.1; NZ_JXZB01000002.1.
DR STRING; 2064.TR51_10710; -.
DR PATRIC; fig|2064.6.peg.2294; -.
DR OrthoDB; 3197455at2; -.
DR Proteomes; UP000032066; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd17923; DEXHc_Hrq1-like; 1.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018973; MZB.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR47962:SF5; ATP-DEPENDENT HELICASE LHR-RELATED; 1.
DR PANTHER; PTHR47962; ATP-DEPENDENT HELICASE LHR-RELATED-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF09369; MZB; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Helicase {ECO:0000313|EMBL:KIQ64675.1};
KW Hydrolase {ECO:0000313|EMBL:KIQ64675.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000032066}.
FT DOMAIN 10..289
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 443..623
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1273..1421
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1973..2005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 44
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 2116 AA; 233991 MW; B7CE056563CAD6EB CRC64;
MDLGTVAGRF RITGAVGRGN MGEVHRAVDL DAPEGSPDRE VALKTILRSR TGLAITGSPE
SKEIERFRRE VDIMRRLSPR HPNLTRLVAG GVDSAAPGGG LPYLAMELLD GNPLADLIDE
EPQLPVSWAA AIAAQVAAGL ASAHAAGVVH RDLKPANVML TRDGTVKILD FGMGRIVDDP
DQVRLTSTGV AVGTARYMAP EQFRAEQVTA SADLYALGCI LYELLIGKPP FSARTAYDLS
EQHQHQAPPS LTVVRPDLPG ELVRLISRLL EKDPGNRPEN ATQVREALVP LAKAPDETAS
LLARHWTAMD PVARLRADLR EPAPAVPEPA PHPARRLPDA MDVFGIHESL IDEYERFTRS
ATVIRDSRIE GFFEDDLAKK SQWPNPWLSL NPFFADGGQV TDLVEDGVLH PKCAEIFQAG
KKETSRRPDG RPLTFHRHQR EAIDAAHAGD SYVLTTGTGS GKSLSYIVPI VDHVLKEREN
EGPGAPRRVR AIVVYPMNAL ANSQLKELEK YLQYGFGTGR EPVTFARYTG QENDEQRSEL
RKNPPDILLT NYVMLELMLT RPDDRDSLIQ MARGLQFLVF DELHTYRGRQ GADVALLIRR
VREACRAAAT LQCIGTSATM STEGSWEDQQ REVAKVAGRL FGTTVLPRRV IGETLIRATE
EAPETVPAER LRAVAAPLSY AALTKDPLAR WVESRFGLER EQDTGRLRRC APGRIEDAAA
ELHATSGVPK DAIQEAIKAT LEAGSQAKHP VTERPLFAFR LHQFLSKGDT VFTTLEDPLT
RPLTRTYQLE QPDTDGKPLF PLAFCRECGQ EYVSVWRTEE SGAFRYEPRR STTASGGRPG
EGYLYIGVPG EDYEWPADPQ RAVDDRRLPE SWLEPDAQGV NVVKKSYRPR VPLRVVVDPY
GQESGDGLAA AFVPAPFLFC VHCQVSYEKT RGRDFAQLAT LDQEGRSSAT SVISASIVKS
LRAVPEGVLS AEARKLLTFV DNRQDASLQA GHFNDFAQVT QLRGALYQAA SQAGEDGLHH
DDLAQAVCDV MGLAPREYTG NADMAPSLER RAGKTFRDVV GYRLYRDLER GWRITMPNLE
QTGLLRIDYE DLDWIADQQD RWQAAHSALR DAEPALRAEV ARTLLDFMRR ALAIDVQYFR
DDFDSLQRAS EERLTGPWVL SESDRPGVGT AYPTSSKPGT ERTATFLSAR GKFGKYLRRT
APAFRALNQA DLQTVIEDLL KVLCKADLVH EVEVAPETSG PVFRRRSATA KRIGYRVSAA
SLIWHAGAGE TGTVDPLTRT YHSGEGPRVN PFFRHLYKEA AAGLAGLFAR EHTAQVTPED
RERREEEFRT AELPLLYCSP TMELGVDISS LNAVMMRNVP PTPANYAQRS GRAGRSGQPA
LVTTYCATGN SHDQYYFRRS QEMVAGQVAP PRLDLANEDL VRSHLQGIWL AETGMRLGRA
VPDVIDVAYD PDGEERPDPN MPLPLLPEPR DLSLDESAQR RAITAAHTVL APLVADFADT
TWWHDDWIEE QIAKAPTVFD NAFDRWRQLF RAAVIDQYEQ NRRVVDHTLS PGEQARARSR
RREAETQTAL LLNRSTDSKS VMSDFYPYRY LASEGFLPGY SFPRLPLAAY IPRSGNRRNA
DGDYLQRPRF LAIREFGPGA LIYHEGARYQ VTRTQLPPDA SGDLATAEAR RCNGCGYHYA
VQPGNDVCEM CGETLPSPRS GLLQLHTVYT SPRERISSDE EERRRAGFRL QTSYAFQDHG
TRKGRLTSHV TDAGGAPVLD LDYGDSATVR ITNLGRVRDK QGEPDGYWLD LGDGRWLNDK
SAAEAIEGAG LPVVDEDGNE KRRKKRVLPY VEDRRNILVV TLDEPQPEPV ALSFMYALER
GVEAAFELED AELTAELLPP DDGPRRRILF TEAAEGGAGV LRRLQHDRDA LAQAARAALE
ICHFDPAGGP AEGQECARGC YECLLTYSNQ GHHQQLSRHA ARPLLVRLAA ARTERESRGE
SRSEQFHRLT AGAPGDTRTG TGTGTGTGTG LETDFAALVE AGDLLGWLKA KGHRLPDEVS
AFVPEAAARP DLIFRLGDAN VAVFVDSPAH GEDATRDDEA VDRLEDQGWD VLRFPVGAGT
DWDAIVAANS GYFYTR
//
