ID A0A0D0SQW8_STAGA Unreviewed; 296 AA.
AC A0A0D0SQW8;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:SUM30865.1};
DE EC=1.1.1.157 {ECO:0000313|EMBL:SUM30865.1};
GN Name=fadB2 {ECO:0000313|EMBL:SUM30865.1};
GN ORFNames=NCTC12195_00265 {ECO:0000313|EMBL:SUM30865.1};
OS Staphylococcus gallinarum.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=1293 {ECO:0000313|EMBL:SUM30865.1, ECO:0000313|Proteomes:UP000255277};
RN [1] {ECO:0000313|EMBL:SUM30865.1, ECO:0000313|Proteomes:UP000255277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12195 {ECO:0000313|EMBL:SUM30865.1,
RC ECO:0000313|Proteomes:UP000255277};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000256|ARBA:ARBA00004305}.
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DR EMBL; UHDK01000001; SUM30865.1; -; Genomic_DNA.
DR RefSeq; WP_042737849.1; NZ_RXWT01000324.1.
DR AlphaFoldDB; A0A0D0SQW8; -.
DR STRING; 1293.SH09_01560; -.
DR OrthoDB; 9771883at2; -.
DR Proteomes; UP000255277; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43561; -; 1.
DR PANTHER; PTHR43561:SF3; HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR PIRSF; PIRSF000105; HCDH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:SUM30865.1}.
SQ SEQUENCE 296 AA; 32514 MW; A4033B54E7414164 CRC64;
MTIKNVTVIG AGVLGSQVAF QAAFHGYDVT IYDINDEAVA AGKAKLHKLV GIYGEYFNKV
EQAEQSLDRL SLTSDLTAAV ADADLMIESV PEIKEIKIDF YKEVAKVAPE KTIFASNSST
MIPSDFKEFT GRPEKFLALH FANEVWKNNT AEVMGHADTD KKYEEELLDF AEKIGMLPIH
VKKEQPGYIV NSLLVPLLQA AEVLYANGVG EIEDIDRSWM VATGAPVGPF GMLDIVGLTT
AYNIAKMSSL NSPQMANVAE MLKAYVDEGK LGTATGEGFY KYPNPAYREF FKDTNK
//