ID A0A0D0WTP1_9ACTN Unreviewed; 595 AA.
AC A0A0D0WTP1;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=GTP pyrophosphokinase {ECO:0000313|EMBL:KIR60815.1};
GN ORFNames=TK50_23470 {ECO:0000313|EMBL:KIR60815.1};
OS Micromonospora haikouensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=686309 {ECO:0000313|EMBL:KIR60815.1, ECO:0000313|Proteomes:UP000032254};
RN [1] {ECO:0000313|EMBL:KIR60815.1, ECO:0000313|Proteomes:UP000032254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JXNU-1 {ECO:0000313|EMBL:KIR60815.1,
RC ECO:0000313|Proteomes:UP000032254};
RA Long Z., Huang Y., Jiang Y.;
RT "Sequencing and annotation of Micromonospora carbonacea strain JXNU-1
RT genome.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Purine metabolism. {ECO:0000256|ARBA:ARBA00025704}.
CC -!- SIMILARITY: Belongs to the RelA/SpoT family.
CC {ECO:0000256|ARBA:ARBA00007476}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIR60815.1}.
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DR EMBL; JXSX01000003; KIR60815.1; -; Genomic_DNA.
DR RefSeq; WP_043967185.1; NZ_JXSX01000003.1.
DR AlphaFoldDB; A0A0D0WTP1; -.
DR PATRIC; fig|47853.6.peg.4918; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000032254; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KIR60815.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000032254};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KIR60815.1}.
FT DOMAIN 83..180
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 416..478
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
SQ SEQUENCE 595 AA; 65704 MW; 8AE397B9DC9F9E68 CRC64;
MDVDAGHGAA LGGALPTQPG DLPLARRLRS LLSWPTGETD PVTHLIRTHR GIHPGTEASV
LRRAYTIAEN MHRGQFRKSG EPYITHPLAV AQICAELGMD ATTLVAALLH DTVEDTRYTL
QALAEDFGGE VAHLVDGVTK FDKAFYGKAA EAETTRKMIV AAGKDVRVLI IKLADRLHNM
RTLGVRSAAS RERIARKTLE VLVPLCDRLG IQTLKRELDD VVLLHLEPDE HARIARFVHD
RPGWSAYLDD VVAKAKVALR RSRVDAQVSP RPRHLYSIWK DTVAGGHSVP FDLPRIVIVV
DGPATDCYAA LGAVHGLWRP VPGRFKDFIA SPKNNLYRSL HTSVCGPKDR TVEVLIRTEE
MHRAAEYGIA ADFRFPRPAG AAGQAEQLDW LRRVLDWEQE APDPAQFLES LRCDLAEAQI
QVVVEGRQVV LPAGATPVDV AYELGPDRGD RCLAARINGR LAPLSSELEE GDVVEIFTES
DAESGFEADV APRGPRREWL GFVKSPHAQM QINRWFAEHT EPGISIADKV RLGRATIGLA
LRKHDRGLAN DLPLLRLSEE LGYPDLETLL VAVFDRALEP DAVVLQLIDL VDHRQ
//
