ID   A0A0D1EKI2_9RHOB        Unreviewed;       346 AA.
AC   A0A0D1EKI2;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE            EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN   Name=echA8_1 {ECO:0000313|EMBL:KIT16270.1};
GN   ORFNames=jaqu_20240 {ECO:0000313|EMBL:KIT16270.1};
OS   Jannaschia aquimarina.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Jannaschia.
OX   NCBI_TaxID=935700 {ECO:0000313|EMBL:KIT16270.1, ECO:0000313|Proteomes:UP000032232};
RN   [1] {ECO:0000313|EMBL:KIT16270.1, ECO:0000313|Proteomes:UP000032232}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GSW-M26 {ECO:0000313|EMBL:KIT16270.1,
RC   ECO:0000313|Proteomes:UP000032232};
RA   Voget S., Daniel R.;
RT   "Genome Sequence of Jannaschia aquimarina DSM28248, a member of the
RT   Roseobacter clade.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC         methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC         ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001709};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KIT16270.1}.
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DR   EMBL; JYFE01000037; KIT16270.1; -; Genomic_DNA.
DR   RefSeq; WP_043918837.1; NZ_JYFE01000037.1.
DR   AlphaFoldDB; A0A0D1EKI2; -.
DR   STRING; 935700.jaqu_20240; -.
DR   PATRIC; fig|935700.4.peg.2090; -.
DR   Proteomes; UP000032232; Unassembled WGS sequence.
DR   GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:UniProtKB-EC.
DR   CDD; cd06558; crotonase-like; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR045004; ECH_dom.
DR   InterPro; IPR032259; HIBYL-CoA-H.
DR   PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR   Pfam; PF16113; ECH_2; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lyase {ECO:0000313|EMBL:KIT16270.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000032232}.
FT   DOMAIN          14..331
FT                   /note="Enoyl-CoA hydratase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF16113"
SQ   SEQUENCE   346 AA;  36895 MW;  3608E826AB204D72 CRC64;
     MSDDIHIRIE GRAGRITLSR PKALNALTWD MCLAIERALD SWEADEAVSL ILIDGAGERA
     FCAGGDIAEM HEAAGRGDYG YGQRFWRDEY RMDAKLARFP KPVVTLLHGF VMGGGVGVGC
     HASHRVVRDD SRIAMPECAI GLVPDVGGSL LLRRAPGRLG AFLGVTGHRM GPGDAIRAGF
     ADTYVPGDWA ALTDALCEAG DVAALDAAAA PAPEAALTGW QEEIDRLYAA ATLADLSRAV
     RDDGPAAQAT RKALDANSPL AMACALEMQQ RLAPTASIET ALGLEYRFTH RALQSSDFVE
     GIRARIIDKD NAPVWRHPGP EAVPPVEVSA MLRPLGPDAL NLEETP
//