ID A0A0D1LRC7_9MYCO Unreviewed; 3073 AA.
AC A0A0D1LRC7;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=3-oxoacyl-ACP synthase {ECO:0000313|EMBL:KIU18616.1};
GN ORFNames=TL10_02010 {ECO:0000313|EMBL:KIU18616.1};
OS Mycolicibacterium llatzerense.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=280871 {ECO:0000313|EMBL:KIU18616.1, ECO:0000313|Proteomes:UP000032221};
RN [1] {ECO:0000313|EMBL:KIU18616.1, ECO:0000313|Proteomes:UP000032221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLUC14 {ECO:0000313|EMBL:KIU18616.1,
RC ECO:0000313|Proteomes:UP000032221};
RA Greninger A.L., Langelier C., Cunningham G., Chiu C.Y., Miller S.;
RT "Genome sequence of Mycobacterium llatzerense and Mycobacterium immunogenum
RT recovered from brain abscess.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIU18616.1}.
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DR EMBL; JXST01000002; KIU18616.1; -; Genomic_DNA.
DR STRING; 280871.TL10_02010; -.
DR PATRIC; fig|280871.6.peg.411; -.
DR OrthoDB; 4746285at2; -.
DR Proteomes; UP000032221; Unassembled WGS sequence.
DR GO; GO:0005835; C:fatty acid synthase complex; IEA:InterPro.
DR GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NADH) activity; IEA:InterPro.
DR GO; GO:0004312; F:fatty acid synthase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00828; elong_cond_enzymes; 1.
DR CDD; cd03447; FAS_MaoC; 1.
DR CDD; cd08950; KR_fFAS_SDR_c_like; 1.
DR Gene3D; 1.20.930.70; -; 1.
DR Gene3D; 3.30.70.3320; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.90.25.70; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR013565; Fas1/AflB-like_central.
DR InterPro; IPR047224; FAS_alpha_su_C.
DR InterPro; IPR003965; Fatty_acid_synthase.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR10982:SF23; FATTY ACID SYNTHASE SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10982; MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF18094; DNA_pol_B_N; 1.
DR Pfam; PF08354; Fas1-AflB-like_hel; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR Pfam; PF16073; SAT; 1.
DR PRINTS; PR01483; FASYNTHASE.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000032221}.
FT DOMAIN 2538..2993
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 1730..1753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3073 AA; 326794 MW; 21E84860C107B705 CRC64;
MTINEHRNVT SGNTETVAAS ANALVDLLNA GEPYAVAFGG QGASWLENLE ELVSSAGIES
ELSEIVGEAA LLLEPVAREL VVVRPIGFEP MQWVRSLAAD EPLPSAKQLT TAAISGPGIL
LAQMAAIRAV QRQGLDLAGT PPVAVAGHSQ GIIAAEALKA NGTRDAELLA LLQLIGAAGS
LVSRRRGMVG RGDKSPMVSV TNVDPERIAE LLEDFSQDVR TVLPPVLSIR NGRRSVVITG
TPEQLARFEL YCSKITEKDE AERKNKLRGG AVFSPVFQGV QVEVGFHTPR LADGIEVVDR
WAAKCGIDTE LAHAMTEAIF VKPIDWVAEV ERMHEAGARW IIDLGPSDTV TRLTSPIIRG
LGVGIVPAAT RAGQRSLFTV GAAPVVQPAW SSFAPTAVEL PNGDVKLSTK FTRLTGRSPI
LLAGMTPTTV DAKIVAAAAN AGHWAELAGG GQVTEEIFEN RVAELTQLLE PGRAIQFNSL
FLDPYLWKLQ LGGKRIVQKA RQSGAPIDGV IVTAGIPELE EAVALIEELH EIGITNVVFK
PGTVDQIKSV IKIAEEVPGR EIIVHVEGGR AGGHHSWEDL DDLLVSTYSD LRKQANLTIC
VGGGIGTPER AAEYLSGRWA ETYGFPLMPV DGILVGTAAM ATLEATTSPQ VKQLLVDTKG
TDHWVGAGKA QGGMASGRSQ LGADIHEIDN TASRCGRLLD EVAGDAEAVA ERRDEIIAAM
ANTAKPYFGD VADMTYQQWL QRYVELAIGD GSSTADTKRD HSQWLDVSWR DRFEEMLQRA
EARLNPADAG PIDTLFPATA EGEALLEDPQ RAIAELLARY PEAQTLRLHP ADIPFFITLC
KTLGKPVNFV PVIDKDVRRW WRSDSLWQAH DARYDADQVC VIPGTAAVAG ITRVDEPVGD
LLDRFEQAAI DEVLAAGVKP VPAVSRRQAR ADITGPLAVV LDSPDVLWAG RTAINPVHRI
GAPSEWQVNE NRSATHPSTG ARLELDGDSV TLNVPLSGVW IAIHFTLPAA TVDGGMPVVT
TDDASAAMRA VLAIAAGADG VDSLPVVADN VATVTADWDP EEVADHTGVT ATFGAPLAPG
LTLVPDALVG RCWPAVFSVI GAAVTDDGIP VVEGLLSLVH LDHAAQLLAP MPAERAELTV
TATASAAYDT EVGRVVPVTV SITDAEGTEL ARLEERFAIR GRSGAAELTD PVRAGGAITD
NATETPRRRR RDVTVTAPVD MSAFAVVSGD HNPIHTDRAA ALLAGLKSPI VHGMWLSAAA
QHVVTATDGR ATPPARLVGW TSRFLGMVLP GDEIEFRVDR VGIDRGAEII EVTAKVGGEL
VMAASAQLAA PKTVYAFPGQ GIQHKGMGME VRARSKAARK IWDSADKFTR DVLGFSVLHL
VRDNPTSIIA SGVHYHHPDG VLFLTQFTQV AMATVAAAQV AEMREQGAFV EGAIACGHSV
GEYTALACVS GVYELEALLE VVFHRGSKMH DIVPRDAKGR SDYRLAAIRP SQIDLDDDDV
TDFVARIAEE TGEFLQIVNF NLRGSQYAIA GTVRGLDALE AEIERRREIT GGKRSFILVP
GIDVPFHSEV LRVGVNDFRR ALDRVMPHGQ DPSILVGKYI PNLVPRPFTL DKDFIQEIRD
LVPAEPLDEI LADYDTWRNE KPSELMRKVV MELLAWQFAS PVRWIETQDL LFIEEAAGGL
GVERFVEVGV KTMPTVAGLA TNTLKLPEYS HNTTEILNVE RDAAVLFATD TDPEPEDDAP
SAPAAAAEAP AEAVAAAPVP AAAPAAPAGG PRPDDITYDA ADATMALIAL SAKMRIDQIE
PLDSIESITD GASSRRNQLL VDLGSELNLG AIDGAAEADL SGLKGQVTKL ARTYKPFGPV
LSDAINDQLR TVLGPSGKRP AYIAERVSKA WELGPGWAKH VTAEVALGTR EGSSVRGGDM
GGLHSGALAD ANAVDKVIDA AVTAVGARKG IAVSLPSAGG AGGGVVDSAA LNEFAEKVTG
PNGVLAGAAR LILGELGLQT PVSAPEATDS ELIDLVTAEL GSDWPRLVAP SFDGRKAVLF
DDRWASARED LARIWLLEED AVNADWAKLS ESFEGAGHVV ATQASWWQGK ALAAGRTLHA
ALYGRAAAGA ENPGKGRYAN EVAVVTGASK GSIAASVVGQ LLAGGASVIA TTSKLDDDRL
AFYRTLYRDH ARFDAQLWVV PANMASYNDI DALVEWVGTE QVENLGPKAI HLKDAQTPTL
LFPFAAPRVA GDLSEAGARA EMEMKVLLWA VQRLIGGLSH IGSDRDIASR LHVVLPGSPN
RGMFGGDGAY GESKAALDAV VARWKAETSW SGRVSLAHAL IGWTKGTGLM GHNDAIVGAV
EEAGVITYTT EEMAAMLLNL CSIDAKVSAS REPIQVDLTG GLGDIELDMA ELAAKAREEM
VAEATVDEED LEGTISALPS PPRGYQAAPA PEWADLDIDP ADMVVLVSGA ELGPYGSSRT
RFEMEVSGEL SAAGVLELAW TTGLVKWEDD PKPGWYDTTT GDLVDESELV ERYHETVLER
VGIRQWVDDG ALGSDHASPL LVSVFLDKDF SFVVSAEADA RAFHQFDPEH TVIAPVPDSS
DWQVTRKAGT EIRVPRKVEL SRTVGAQVPT GFDPQVYGVT PDMTSSIDRL ALWNLVTTVD
AFLSAGFSPE ELMRWVHPSL VASTQGTGMG GMTSMQTMYH GNLLGRNKPN DILQEVLPNV
FAGHVVQSYI GSYGAMIHPV GACATAAVSV EEGVDKIRLG KAEFVVAGGY DDLTLEAIIG
FGDMSATAET AMMRARGISD SKFSRANDRR RLGFVEGQGG GTVLLARGDL AVKMGLPIQA
VVAYVSSFGD GVHTSIPAPG LGALGAGRGG RQSQLVRDLA KLGVTPDDIA VISKHDTSTL
ANDPNETELH ERLAASMGRS PGNPLFIVSQ KSLTGHSKGG AAAFQMLGLC QVLRDGVIPP
NRSLDCVDDE LANAQHFVWV REALKFGDRL PLKAGLVTSL GFGHVSGLIA LVHPQALVAA
LDPAEREDYL RRSGERVLAG QHRLASAIAG GRPLYEKPAD RRFNHDAPEK RQEADMLLNA
DARLGEDGWY ARS
//
