ID A0A0D1VGU9_ANEMI Unreviewed; 724 AA.
AC A0A0D1VGU9;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=AF333_13735 {ECO:0000313|EMBL:KON96379.1},
GN SAMN04487909_102187 {ECO:0000313|EMBL:SDI22657.1};
OS Aneurinibacillus migulanus (Bacillus migulanus).
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
OC Aneurinibacillus group; Aneurinibacillus.
OX NCBI_TaxID=47500 {ECO:0000313|EMBL:KON96379.1, ECO:0000313|Proteomes:UP000037269};
RN [1] {ECO:0000313|EMBL:KON96379.1, ECO:0000313|Proteomes:UP000037269}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 2895 {ECO:0000313|EMBL:KON96379.1,
RC ECO:0000313|Proteomes:UP000037269};
RA Liu B., Wang J., Zhu Y., Liu G., Chen Q., Chen Z., Lan J., Che J., Ge C.,
RA Shi H., Pan Z., Liu X.;
RT "Fjat-14205 dsm 2895.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SDI22657.1, ECO:0000313|Proteomes:UP000182836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 2895 {ECO:0000313|EMBL:SDI22657.1,
RC ECO:0000313|Proteomes:UP000182836};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
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DR EMBL; LGUG01000004; KON96379.1; -; Genomic_DNA.
DR EMBL; FNED01000002; SDI22657.1; -; Genomic_DNA.
DR RefSeq; WP_043064063.1; NZ_LGUG01000004.1.
DR AlphaFoldDB; A0A0D1VGU9; -.
DR STRING; 47500.AF333_13735; -.
DR PATRIC; fig|47500.8.peg.1522; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000037269; Unassembled WGS sequence.
DR Proteomes; UP000182836; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR025589; Toprim_C_rpt.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR Pfam; PF13342; Toprim_Crpt; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:KON96379.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000037269};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..140
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 724 AA; 81963 MW; 4527EF83639E72EC CRC64;
MKVIIAEKPD QGTKLAAPFR SKKQQGYIEI SPNETFQDGA LITWAVGHIC ELVAPEEYNS
AWKKWSLDNL PIIPEQFKYK VMKAKAQQFQ IIKKLLQRAD VNEIIHAGDA GREGELIVRT
IIQQTGTKKP MKRLWISSLT EKAVRQGFAQ LRDEADTRNL YYEAYSRACA DWVVGMNASR
VYSLLMKQHG VNDVFSAGRV QTPTLALVVK REREIADFTS EPFWEVLAEF QMDGKQYQGK
WQKDGESRLN DPKMAEAIAA FCRNKPAEIK DAQTERKEFQ PPYLFNLSGL QATANKAYKF
PPKKTLDVAQ QLYVKGYISY PRSDSSFVTE GEARTFPEIL EKLGSKPEYA PFFPLPVHSV
LTNKRYVNEK KVTDHYAIIP TEQVPALDKL SDDERKIYDL IVRRLLAAHY ESAIFDYTTV
LTFVDNRAEF LSKGRQQIRE GWRKVLFGEG EKEEEEPLLP PLTEGEKGMV ERIAVKESKT
QPPKRYTEGQ LITLMKTAGK HLEDQELEKV LAKTEGLGTE ATRAGIITML KDRRYIEVKK
NQVYATPKGM LLIAAIGEKI LASPEMTARW EQRLSEIGQG EASAKDFMEQ AKKLAVKIIQ
DAVEQAKSWT FDNIDMDEVK ANAPSRKGKS KAPAKVGVCK LCGGDVVDKG TFYGCTNYSK
TKCSFTFSKK ILGKTISQTN AKKLLKEGKT DLIKGFKKGD KAFDAYIIWD DKNGKPSFAF
PDRK
//
