ID A0A0D1X066_9EURO Unreviewed; 624 AA.
AC A0A0D1X066;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000259|PROSITE:PS50850};
GN ORFNames=PV11_08336 {ECO:0000313|EMBL:KIV80861.1};
OS Exophiala sideris.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=1016849 {ECO:0000313|EMBL:KIV80861.1, ECO:0000313|Proteomes:UP000053599};
RN [1] {ECO:0000313|EMBL:KIV80861.1, ECO:0000313|Proteomes:UP000053599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 121828 {ECO:0000313|EMBL:KIV80861.1,
RC ECO:0000313|Proteomes:UP000053599};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala sideris CBS121828.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000256|ARBA:ARBA00010992,
CC ECO:0000256|RuleBase:RU003346}.
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DR EMBL; KN846953; KIV80861.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D1X066; -.
DR STRING; 1016849.A0A0D1X066; -.
DR HOGENOM; CLU_001265_43_5_1; -.
DR OrthoDB; 932119at2759; -.
DR Proteomes; UP000053599; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015798; P:myo-inositol transport; IEA:UniProt.
DR GO; GO:0015791; P:polyol transmembrane transport; IEA:UniProt.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR NCBIfam; TIGR00879; SP; 1.
DR PANTHER; PTHR48020; PROTON MYO-INOSITOL COTRANSPORTER; 1.
DR PANTHER; PTHR48020:SF17; SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06870)-RELATED; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053599};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003346}.
FT TRANSMEM 121..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 126..569
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 70756 MW; AF0E62F521757CB1 CRC64;
MAESEEIHEK RSQSSDRTAV GASAANVEHA AKRQRSSVID PDINNLSAAF ENPLSDIPKE
QLLQDVETFC SKHNLMDYLD AFKKGALIAQ RPYETDKISE LTQEDRDILT REHTHRWHQP
WMLYFLVIMC SMAAAVQGMD ETVNNGAQAL YLKQLGITDT NRFSSSMQDN LTGLIVGAPY
LCCAILGCWL TEPMNKVFAR RGTIFISCFI AAVASIWEGV ANSWVNLFVA RFVLGLGIGP
KSSTVPVYSA ECAPAPIRGA LVMMWQMWTA FGIMLGNIMG VAFGGLAPDL GWRLMLGSTV
VLPIIVCAQV YFCPESPRWY IQHNRPEKAF RSFQRLRHCD LQAARDTYYT YVGVELERQA
LKGKNLFTQF VELFTIPRNR RAAWASWIVM FGQQFCGVNV IAYYSTTIFI ESGYSTTDAL
LASMGTGILN WVFALPAVFT IDRWGRRVLL LFTFPFLAVF LLWTGFSFWI KNNKAKVGMV
TTGMYLFECF YSPGEGPVPF TYSAEAFPVT HRDVGMSFAT ATTWCFNFIL SFSWPHLLSA
FKPQGAFGWY GAWCLILWVL ILLFVPETKA LTLEELDQVF GVSTRKHMSY QMKNAIWHFR
VWVLRQKLEP LPPFYRRAEK LNEA
//
