ID   A0A0D1X799_9EURO        Unreviewed;       746 AA.
AC   A0A0D1X799;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   28-JUN-2023, entry version 31.
DE   RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819};
GN   ORFNames=PV11_05703 {ECO:0000313|EMBL:KIV83701.1};
OS   Exophiala sideris.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX   NCBI_TaxID=1016849 {ECO:0000313|EMBL:KIV83701.1, ECO:0000313|Proteomes:UP000053599};
RN   [1] {ECO:0000313|EMBL:KIV83701.1, ECO:0000313|Proteomes:UP000053599}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 121828 {ECO:0000313|EMBL:KIV83701.1,
RC   ECO:0000313|Proteomes:UP000053599};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA   Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Exophiala sideris CBS121828.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC       {ECO:0000256|ARBA:ARBA00009573}.
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DR   EMBL; KN846952; KIV83701.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0D1X799; -.
DR   STRING; 1016849.A0A0D1X799; -.
DR   HOGENOM; CLU_013809_0_1_1; -.
DR   OrthoDB; 22264at2759; -.
DR   Proteomes; UP000053599; Unassembled WGS sequence.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR011387; TIF2A.
DR   InterPro; IPR013979; TIF_beta_prop-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR   PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR   Pfam; PF08662; eIF2A; 1.
DR   PIRSF; PIRSF017222; eIF2A; 2.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053599};
KW   Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT   DOMAIN          218..412
FT                   /note="Translation initiation factor beta propellor-like"
FT                   /evidence="ECO:0000259|Pfam:PF08662"
FT   REGION          498..697
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        572..592
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   746 AA;  80397 MW;  8FFAF54AE7CF03E2 CRC64;
     MALTTQFAFR TLKGIGVVNG APTYEPLPGL ERPEGNLRCY AYSPCGRYFA WASPEKVNII
     SADTGAIVST LPAENVFELG FSPLGTYIIT WQRSAKDENG DAVKNLKVWL VIDEKALAED
     VEKEPLSGFV QKSQTGWNLQ YTHDETFCAR VVTNEVQIYE SHDLRTVWNK IRVEGVADFA
     VSPGKSHTIA VFVPERKGQP AAVRVYNVPE FTTPASQKNF FKGDKVQLKW NENGSSLIVL
     AQTEVDKTGK SYYGETTLYL LSANGGFDSR IDLDKEGPIH DVSWNPKSNS FAVVYGYMPA
     KTVIFNAKAQ PVHTFALAPR NTVLFSPHGR FVLVAGFGNL AGQMDIYDLE KDVSKICTIE
     ASNASVCEWS PDGVHILTAT TSPRLRVDNG IRIWHAGGTL MYNEDMSELY HVCWRPQSPS
     AHPLSADPLS PVPAPHSSAT QYMAARKTPS KPAGAYRPPG ARGQVTPLAF KREDEGGAAY
     VRDGISSFAS NINGFGKARS RAVPGAEPAE DKTPLPPGAA PGGGVSLTGT GEGADGEPLS
     KAAKKNAKKR EAKKAAAAAA RDQPTPNLAP EHGAEKNQSP SRSPQGRGHQ RSRSRNYVPA
     PAPGLEPPSG PRKERSRSNS RRQRGDAAGS SHGFANGHPK GPGHLLATPN QKPRHANAPA
     NISTALPPPP LVPQDQSPPE LEVTSPLTPG GDPKEKKVRG LLKKIRAIDD LKMRHAGGEK
     LEDTQVRKIS SEDSVRKELA GLGYTG
//