ID A0A0D1XPB8_EXOME Unreviewed; 612 AA.
AC A0A0D1XPB8;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Probable lysosomal cobalamin transporter {ECO:0000256|ARBA:ARBA00017088};
GN ORFNames=PV10_07295 {ECO:0000313|EMBL:KIV89941.1};
OS Exophiala mesophila (Black yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=212818 {ECO:0000313|EMBL:KIV89941.1, ECO:0000313|Proteomes:UP000054302};
RN [1] {ECO:0000313|EMBL:KIV89941.1, ECO:0000313|Proteomes:UP000054302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 40295 {ECO:0000313|EMBL:KIV89941.1,
RC ECO:0000313|Proteomes:UP000054302};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala mesophila CBS40295.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable lysosomal cobalamin transporter. Required to export
CC cobalamin from lysosomes allowing its conversion to cofactors.
CC {ECO:0000256|ARBA:ARBA00025515}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC {ECO:0000256|ARBA:ARBA00009901}.
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DR EMBL; KN847524; KIV89941.1; -; Genomic_DNA.
DR RefSeq; XP_016221515.1; XM_016372183.1.
DR AlphaFoldDB; A0A0D1XPB8; -.
DR STRING; 212818.A0A0D1XPB8; -.
DR GeneID; 27325140; -.
DR VEuPathDB; FungiDB:PV10_07295; -.
DR HOGENOM; CLU_028341_1_0_1; -.
DR OMA; FWAQFVF; -.
DR OrthoDB; 8533at2759; -.
DR Proteomes; UP000054302; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR InterPro; IPR006876; LMBR1-like_membr_prot.
DR PANTHER; PTHR16130:SF2; LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1; 1.
DR PANTHER; PTHR16130; LYSOSOMAL COBALAMIN TRANSPORTER-RELATED; 1.
DR Pfam; PF04791; LMBR1; 1.
PE 3: Inferred from homology;
KW Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054302};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 20..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 262..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 612 AA; 68381 MW; 4FB9AA06400244A9 CRC64;
MLLLPSGLPE PSVHTMASVG YVQVALIWVV YAIAVVLLLS IASLFVYLYQ THRERSILVT
TVCIFTITAL LATVLLLPVD VALVSSTTSS RTGQRKDWAS QDKVDDITFT LRVVYYFLYS
LDAVLCLVVI PFTYFWYEEY DEVAQEEGSQ TFGSRFWGAL KFTLAFVFLV VAIFLVGFFI
PRASNHEGAH FDLDFFKRLL AENRGEKALT FALGILITLG IVLYCFYTAA GLALLPLTLI
KSAPAISAPA LTESTAAQLE NNQERQRQLE GRAQGNPDGL SSKDQRELDA LVREERTLRR
HQRLAAEASG RDRNIFWKIW LKLEAIFRPI KLLLGMLLVL VVLLVFVSML ITGIDKAKNS
ICKRHCGYLL GHINIFQPVN WILVKSAKVF PVDYVIFLLL VLLFFSASVI GIATIGIRIL
WITIFRIRKA HTSPQALLIA TVLLTLMTLA INYSIAMLVA PQYATFGPQT FCDHPPKHPG
EQPDCTNHLQ HIIPCTENTD NPAARNVCTP SVVSTFLNRV TVNYPFFGIV DFWAQFVFLG
IFLMAFILLL FRTPKLSDTD ADEDELEEEE EGLLASTGRR FGATWQDITG RTSHGGRNGG
AQGRGTRDVV DD
//
