ID A0A0D1XSR8_EXOME Unreviewed; 1787 AA.
AC A0A0D1XSR8;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Rho1 guanine nucleotide exchange factor 3 {ECO:0008006|Google:ProtNLM};
GN ORFNames=PV10_05750 {ECO:0000313|EMBL:KIV91186.1};
OS Exophiala mesophila (Black yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=212818 {ECO:0000313|EMBL:KIV91186.1, ECO:0000313|Proteomes:UP000054302};
RN [1] {ECO:0000313|EMBL:KIV91186.1, ECO:0000313|Proteomes:UP000054302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 40295 {ECO:0000313|EMBL:KIV91186.1,
RC ECO:0000313|Proteomes:UP000054302};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala mesophila CBS40295.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN847523; KIV91186.1; -; Genomic_DNA.
DR RefSeq; XP_016222760.1; XM_016370467.1.
DR STRING; 212818.A0A0D1XSR8; -.
DR GeneID; 27323595; -.
DR VEuPathDB; FungiDB:PV10_05750; -.
DR HOGENOM; CLU_001083_0_0_1; -.
DR OMA; DMFYHPG; -.
DR OrthoDB; 2734900at2759; -.
DR Proteomes; UP000054302; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF1; RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Reference proteome {ECO:0000313|Proteomes:UP000054302};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT DOMAIN 946..1138
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1175..1353
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1418..1731
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 192..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1261..1302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..259
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1787 AA; 197687 MW; 22B7F14B79D47DF9 CRC64;
MASYQNGHPH YNQNAHPSST QNSGHPPHTS QSPYPPRPLH RSPSFDAGDD QRFADVPDPS
YRATHPYQAQ HPSAVASSPP VDRGTSITYA NQASSLPFRT NTQHGSPAGG YQYQHQPTPP
AHQTYNPAQF QQQQQQQQQS HQYQYNPQAY ASPQTSYTPV AHQPYVPAAY GDSNLQRHTS
LYNSYGYHDA NSQLNYSAQP PLPPPRSDTL PLSHSLNQYG TYPQDTNQHH LSGHPSNASP
RQNYAAYSPP PPQPPPHEAS LAARPYMQSV SMPEGPYSHE STPSGNQSAT LANYSSPDVN
RNSSFASRVS AQSTSPRLSL ANSPNRMPAS RSPQRQGTID RHPQGRSLPG VPSGSESDND
FFSASQPQAH RRDPSTSGYD DLMQHLDHAI GDASTLDSQR HTHMYRQSQD QGPDSVLPTP
SPQPLLSPDE APTHLNGNIA STGDAYINYG AFTDDSDAEA AAGLAAMNAL DEQERAEDMR
RRSGTQGSAT LFPTAIRSDD HSARMVSQDQ SSDSDYTGYD LSGAAGGSYV PDMSYGESQY
GVAATMPSSD LYGRLNTRMS SIRSSGVSSE GRDSQTSGVD SLPPTDNPFS PIHNVARVDT
GGTGGLTEPS PFPRRLSYED GDEATLIESE AGQTSGSTSP SRDSMPDLFF HPGMSQQRPL
PPPPSNSDPS ALRTIPHLIP AGTYTQQSRF SQYTDPGTRV SFPSAPDAYS STLLSPTAVP
RSTSLSSTRS APRSDHPIRS KTESDRAKLL RQQGRPMSDI YDLSSPQTAV GLDLPTIPKK
RYNPSKLTSD QFKKCSEPWA LSSVLAWIRE LAEEEADLKE SSVAEGLVAL FMHKVPTMYN
TEAEALGDRV VKSMVAAGAL VREEEWVKFG PGTMSGVLYQ LTGTGCYSSK LHLYPVKGRC
YSYHCMRTLK KIDVDSLPGE QSTQDWPTFY KLKKEDLEGH DRKEIERQNN LHEVVTGEDF
YLSQLDVIRL LYRDRLAASQ PPIIPTKKLP GFLKEVFGGV DKVKKVNQDY LLGQLKYRQT
EQGPWIVGFS DIFREWIRKA RPIYVEYAAS FPRADYLMRR EAERNLHFKN FLDQAQNDAR
SKKLDWGNYL KSPITRLQRY GLLLSTVYKN MPKESEEKTN LAFALDEIRA ATFECDAKFA
EMGKKMELIE MQTKLRLRAQ MEKEVELNLD HLGREIVFKG DLLRAGEKGF QWVETFAILF
DHYLVLAKPL ARERSREGYY DVSKVPIPMD LLVLESAGDA AVVKSSVKGI AAVTTTVATR
SQTDSRMARA QSAASGDRPG SLTHTNTNLS IGSGGASQSM VPITTLDSGN PKEEKIMYPF
RVKHLGKPET YTLYAPSAQN RQDWCEAIIQ AKTRHAESLY SQNAEPFKLR VLADTAFGYD
GLSHGSRRIL IRGTPLDRAI RETEKKYEGQ GRPAPICRAQ VNCATVFHQP FGRLMCAIGT
DYGVYISEYQ NSRGWTRAIQ MQRISQIAVL EEFNLFLLIS DKALIAYHLD VVCPPSGSHG
PRDDSARKAP QKLSGSKDIG FFVTGRMKER TLVFYKKRDG IASTFKVLEP VLQKSTTTRS
RFLPSSTRRG QTEFFREYDE FYIPAECYGL NLYQSSLAIS TARGVEVLTL EKKQTWSVPN
LRSDQADTQA HLSSIASRIK DLKPLGMFRL GEAEFLVTFE ECAVYVNKHG DISRGVVMEF
VGRAKSACLY SQYLILVDDD FVEIRDAQNG RLKQVVAGKD IKLLDDGGGG SGSGTASQQT
ASLGGGMNGL GLKNFANAPR TPKIVLQHPE YEKSHIVVEL ILTQDEE
//
