ID A0A0D1XXC0_EXOME Unreviewed; 3814 AA.
AC A0A0D1XXC0;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PV10_04145 {ECO:0000313|EMBL:KIV92881.1};
OS Exophiala mesophila (Black yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=212818 {ECO:0000313|EMBL:KIV92881.1, ECO:0000313|Proteomes:UP000054302};
RN [1] {ECO:0000313|EMBL:KIV92881.1, ECO:0000313|Proteomes:UP000054302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 40295 {ECO:0000313|EMBL:KIV92881.1,
RC ECO:0000313|Proteomes:UP000054302};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala mesophila CBS40295.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Serine/threonine protein kinase which activates checkpoint
CC signaling upon genotoxic stresses such as ionizing radiation (IR),
CC ultraviolet light (UV), or DNA replication stalling, thereby acting as
CC a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-
CC Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of
CC DNA damage, involved in the regulation of DNA damage response
CC mechanism. Required for the control of telomere length and genome
CC stability. {ECO:0000256|ARBA:ARBA00025079}.
CC -!- SUBUNIT: Associates with DNA double-strand breaks.
CC {ECO:0000256|ARBA:ARBA00011370}.
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DR EMBL; KN847522; KIV92881.1; -; Genomic_DNA.
DR RefSeq; XP_016224455.1; XM_016368667.1.
DR STRING; 212818.A0A0D1XXC0; -.
DR GeneID; 27321990; -.
DR VEuPathDB; FungiDB:PV10_04145; -.
DR HOGENOM; CLU_000129_1_0_1; -.
DR OMA; CLDLYGQ; -.
DR OrthoDB; 3666795at2759; -.
DR Proteomes; UP000054302; Unassembled WGS sequence.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000054302}.
FT DOMAIN 2637..3192
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3440..3771
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3782..3814
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 164..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2012..2041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3195..3269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2012..2039
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3195..3212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3225..3252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3814 AA; 433465 MW; D100A71E8B8537D7 CRC64;
MTSTMDASQK IDLYAARLTD PKIDTRAKAN TATEVRDSIE SLCSPPATYA KFLATLWPVF
KKILEGKPDF SPTSFEQILR NQILEILHRL QHGPVEVEPY ALEMVDTLLE LVRVENEDNA
VLCLKTIMDL ERSQVKATSG RVQDFLDLIQ EMFEMMDQAV KDTFDSPTTH HQQSSSTPNP
AGGSLQSPRP GSPGTTVSDP GSEKKEHVPL AKGMQSFKVL SECPIIVVSI FQAHRASVPA
NVKKFVPSIK GILLLQAKAQ ERAHEEAEAN GTIFTGVSKD IKNRAAFGDF ITAQVKTMSF
LAYLLRVYAN QLTDFLPTLP VVVVRLLKDC PREKSGARKE LLVAIRHIIN FNYRRIFLNK
IDELLNEKIL IGDGLTVYET MRPLAYSMLA DLIHHVRDSL DRDQIRRTIE VYTKNLHDTF
PGTSFQTMSA KLLLNMAESI TKLENKQDAR YFLIMILDAI GDKFAAMNYQ YKNAVKLSRQ
YAEKSKENHV ETYMDDEDQV LDWDEVDIFT ATPIKTSSPR ERGADPVFDN KFLFKNLVNG
LKNMFFQIKA CNPQGLTIDP ANVPMNWAEV SYGYNAEETR VITKLFHEGA RVFRYYSAEA
PPTDVQYTSP VDFMASHSMA QMTREEKELL EAFGTVFHCI DPATFHEVFQ AEIPHLHELM
FEHTALLHLP QFFLASEATS PAFAGMVLHY LMGKLPEVGT SDIVKSSILL RMFKLSFMAV
TLFSAHNEQV LLPHITKIIT QCVQLSVTAE KPIHYFILLR SLFRSIGGGR FELLYKEILP
LLEMLLETFN HLLQGARDPH DRDLYVELTL TVPARLSHLL PHLNHLMKPL VVALRAGPDL
VGQGLRTLEL CVDNLTADYL DPIMAPIMDE LMTALFEHLK PQPYQHFHSH TTMRILGKLG
GRNRKYLNHP HLLSFRQYTD DAPSFDIRLI ESNRDRAFPM DTAVDLAIRK LSEVTKASAT
KSLDAYYKQQ SFKLISNQVR LFIGSDHLPD NFAALIRLQA NDLVARRFAT YTEMLAESDT
SKPVQKRRDQ EDNLKKLMKA VFTATTIPDL KTQADAFILS ISRHFTIVEL GQALCDAARK
TKEFDVNSGE GAVYLNSRIL ADVISDCLAS DNITVRESAE ASMVAVVETA RTIFGSDSKA
ATLPFFSYLT QTFCYRCREV EWFTKAGATL GIKLLVTELG LGNGFVQSKQ LELIKALLYV
IKDTPQEVPA STRITAQETL EHILKIGLAG SSKESITNEK SPLFMLCATF CVELSHMNKN
ARQTAQKAFS MMAEIVGLEI HEILEPVKDR LLQPIFNKPL RALPFLSQTG FIDAITYCLG
LGHDFVPLND QLNRLMMESL ALADAEAEIL HPKPDEFNNA QLIVNLRVSC LKLLSLAMSL
PEFAAGTQST NNNSTRARII TVFFKLLYSK SPEIIDAANA GLKDVLVQTA KLPKDLLQNG
LRPILMNLQD SKRLTVAGLE GLARLLTLLT NYFKVEIGAR LLEHMRVIAD DALLQKVSFG
LIEQNAQMKI VTAIFNIFHL LPPAATSFMA DLVNGVLDLE SKLRRTVASP FRHPLALYLD
KYPKETWAFF QPLMQEEKYG RFFGQILASD HSNAIREVVM GDIETLIKVA FEVEEEPAKQ
IAAINGIYVV HSICKSDSAK VWLRGQETLR SKILSTGREL EGQLRQDTLQ QPQRLRAEQA
GDQVIDIVTQ YLSESLDDTT FMMEIFSCAS QGKIKPSLQL TKYLYGSVIT DKSLERRFNI
VEKCLDLYSR KNEPQKLKTF LLHSVVNPIL AQNVQNTRRE DNEAGNLADS KLFNLLLEKL
WKSAASLESS DESSQPGIDH SRMEALQLSA FILKYHKDAV SEDRKEIIKY SWGHIKLEDV
INKYAAYVLI CYFIRSYETP PKIAVQIYNQ LLKAHQNEGK VLVSQALEVL APVLPIRMGS
PNNTPGDKRS PHWARLPRKI LNEETGNLQQ VQSIFNFIVR QPDLFYDSRE FFVPTIVQML
QKIAPPPNPS NESKKLALAL ISLIQQWESK RVSASSPTQS AAELTPSKKR DSQGNAKLPP
PQTKERVEYL IPLEHRTLVI KYMINFITGL AERHPVPAAE LKVKAMQKAQ IQALPNDMCK
KAVQLLRDLL APNMWSDVDV GLYEKLLEPI LAGEKADKAD EKQLTCMINA LQVLRILINT
KSDEWILTNM ERVQKLLEKP LKMEDPEIQD CLHLVTDNNK HPPLVRRILE AIPNQQAEDE
DGMDVDSSPS DFPTTYSKIM IGEALSSSNF TSAINNLWTL SLVRPADVDD HIAGAMKALQ
GKLAKEHIHA YAIPPGPPPQ GWRLGEPLMD PYEFALGVDL IKKTIDILAL RMGELNDQRR
PFLSVLASLV EKSFNVEMCN KVLDMVEQWV FNSNEPWPTL KEKTAVLHKM LIFEKWQNQT
LLDRFLELVI KIYEDPTVTR TELTVRLEHA FLIGTRAKDV EMRNRFMSIF NRALSKTASY
RLNYVLTLQN WDTLADSFWL KQASHLIMDS VEMSLPARLH AEDLRLCPVS QLFKASLVSP
EQQKDDLIIE DGLESLITAE RRFNQEMQEV KVRDLLEPII QLQHADDNVA YDVWIKLFPL
CWSALNRDER LDLEKGMVTL LAREYHQRQL NARPNVVQAL LEGVVRARPR FKVPPHVMKF
LSKTYDAWYT ALISLEESTI DPLIDTPAVR ESNLDALVEV YAGLQEDDLF YGTWRRRCKF
METNAALSYE QHGIWDKAQQ LWESAQVKAR TGVVPFSQGE YYLWEDHWMI CAQKVQQWDI
LGEFAKHENF SDLLLESAWR NYEAWSGDDN RNQLDGMIKS VSDAPTPRRT FFQAFMALLR
YNSKQMSRAE FQHVCDEAIQ LSIRKWHQLP KRITNAHIPI LQNFQQLVEL HDASIICDSL
MGTNDRNLDT KSQEVKMMLQ AWRDRLPNIW DDVNAWQDLV TWRQHVFQLV NSTYLPLLPQ
GGNNVGNNSY AFRGYHETAW IINKFAHVAR KHQMPDVCIT QLGKIYTLPN IEIQEAFLKL
REQAKCHYQN KSELNNGLDV INNTNLNYFG AQQKAEFYTL KGMFLAKLQH AEEANEAFGV
ALYYDLRLPK AWAEWGQYSD RKFKEDPSNI EAASNAVSCY LEAAGLYKSA KSRKMLSRVL
WLLSLDNEEG HIAKAFEDFK GETPVWYWTT FVPQLLGSLE HKEAQLAKSV LVKIAKAFPQ
SLFYHLRATR EEFLSKKKQS ENQKRAQQAK QEKSEGGSRP GTANGEAGAN ANANANGSAS
PKPKQEANGE ASTNGAEAEK KQEPRKPWDH TDEIMAGLKT AFPLLALSME TMTDQLSKHF
KCPPDEDAHR LIVALLNDGL AYISRAPGTY AEGAKLPPST EANIARFVTS VLPAHIRKSF
EADFVQTRPT MYEYIHKLRR WRDKFEQKLD HKQQWNPLES YSHHLSEFKF LKFDDSVEVP
GQYQQHKDKN TDFVRIERFM PTVEVVRGNS ICHRRLTIRG HDGSLHPFAV QHPTGGKVRR
EERIVQLFRI FNQTLAKRKE SRRRNLYFHL PIFVPIAPYI RLVQDDASYV TFQTIYEDFV
RKAPGMSRDD PMMFVLSKSR TIADQQKTSP RTAEQLAVLK TEIFNTIQER WVPNTILLKY
FQAVYPNFAD FWLFRRQFSY QYAATTFMTY VMHISARYPS KFAISRSTGD IWASDLLPNL
NSARAYFFNP EAVPFRLSPN VQTLMGPLAV EGIFTASLMA IARCIAEQDQ GYEMEQQLSI
FVRDEMYNWA GGRSQSGSEK MEGQHLRELV GQNADFVVRR ALALAKTQGT VGGGGENGGL
NGVLPACQNV VDLVSRATDP MKLSAMDPLW MAWL
//
