ID   A0A0D1YCC7_9EURO        Unreviewed;       604 AA.
AC   A0A0D1YCC7;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=methionine--tRNA ligase {ECO:0000256|ARBA:ARBA00012838};
DE            EC=6.1.1.10 {ECO:0000256|ARBA:ARBA00012838};
GN   ORFNames=PV11_10201 {ECO:0000313|EMBL:KIV78489.1};
OS   Exophiala sideris.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX   NCBI_TaxID=1016849 {ECO:0000313|EMBL:KIV78489.1, ECO:0000313|Proteomes:UP000053599};
RN   [1] {ECO:0000313|EMBL:KIV78489.1, ECO:0000313|Proteomes:UP000053599}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 121828 {ECO:0000313|EMBL:KIV78489.1,
RC   ECO:0000313|Proteomes:UP000053599};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA   Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Exophiala sideris CBS121828.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363039}.
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DR   EMBL; KN846954; KIV78489.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0D1YCC7; -.
DR   STRING; 1016849.A0A0D1YCC7; -.
DR   HOGENOM; CLU_009710_9_0_1; -.
DR   OrthoDB; 166496at2759; -.
DR   Proteomes; UP000053599; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006431; P:methionyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd00814; MetRS_core; 1.
DR   Gene3D; 2.170.220.10; -; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   InterPro; IPR041872; Anticodon_Met.
DR   InterPro; IPR014758; Met-tRNA_synth.
DR   InterPro; IPR023457; Met-tRNA_synth_2.
DR   InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR   InterPro; IPR033911; MetRS_core.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   NCBIfam; TIGR00398; metG; 1.
DR   PANTHER; PTHR43326:SF1; METHIONINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43326; METHIONYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF19303; Anticodon_3; 1.
DR   Pfam; PF09334; tRNA-synt_1g; 1.
DR   PRINTS; PR01041; TRNASYNTHMET.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363039};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363039};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363039};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053599}.
FT   DOMAIN          53..420
FT                   /note="Methionyl/Leucyl tRNA synthetase"
FT                   /evidence="ECO:0000259|Pfam:PF09334"
FT   DOMAIN          466..565
FT                   /note="Methionyl-tRNA synthetase anticodon-binding"
FT                   /evidence="ECO:0000259|Pfam:PF19303"
SQ   SEQUENCE   604 AA;  69144 MW;  0E62B908676858CE CRC64;
     MLALEHRARS FFLQCRASAR YTLPRSCLVN RGTQQRTYIV KQEPGADDGR RHYYVTSPIF
     YVNSAPHVGH LYTLVLADVL KRWAILRGDL GAKLLTGTDE HGMKIQKAAQ KANTDVKLFC
     DHHAQQFKSL CNAANITYDR FIRTTDEDHK SAVEHFWNEL NHAGYIYEGK HEGWYCVSDE
     TFYPETQVRR VLDPSTGDTK IVSIETGKEV EWTSEINYHF RLSAFRDQLL KHYTEGLSLI
     VPKQRMALVM NEIQNGLSDL SISRPTSRLS WGIRVPGDES QTIYVWLDAL INYLTMTGYP
     LTDRNDPTSI WPPICQVIGK DIIRFHTIYW PAFLMAVGLP VTRRFLTHAH WTLNNEKMSK
     SAGNGVNPFL AIERYGVDTI RFYMAYNGGI VDDAMYENSR VAETYKHVLR DGLGNLLQRV
     FKSKQFNVKE SVQVVANDQE LAELLSQETL DGHSEQFQSL HKNIKLLAKQ LSVVAERTEK
     AMREPNPRTA AHHIVELIRH TNKYFHNSAL WGLIGTKDPK ELRLAHYGVY MSAESIRIIA
     ILLQPFMPEK MKTALDMIEV DDSKRTFNHA QLGADFTYGC LPPDPEPGRR KPAEQLFPVL
     LSDN
//