ID A0A0D1ZBZ5_9EURO Unreviewed; 1067 AA.
AC A0A0D1ZBZ5;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Rad4 beta-hairpin domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PV07_08462 {ECO:0000313|EMBL:KIW25271.1};
OS Cladophialophora immunda.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Cladophialophora.
OX NCBI_TaxID=569365 {ECO:0000313|EMBL:KIW25271.1, ECO:0000313|Proteomes:UP000054466};
RN [1] {ECO:0000313|EMBL:KIW25271.1, ECO:0000313|Proteomes:UP000054466}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 83496 {ECO:0000313|EMBL:KIW25271.1,
RC ECO:0000313|Proteomes:UP000054466};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Cladophialophora immunda CBS83496.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR EMBL; KN847044; KIW25271.1; -; Genomic_DNA.
DR RefSeq; XP_016245487.1; XM_016395631.1.
DR AlphaFoldDB; A0A0D1ZBZ5; -.
DR STRING; 569365.A0A0D1ZBZ5; -.
DR GeneID; 27347656; -.
DR VEuPathDB; FungiDB:PV07_08462; -.
DR HOGENOM; CLU_003639_1_1_1; -.
DR OrthoDB; 181129at2759; -.
DR Proteomes; UP000054466; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.60.290; Rad4, beta-hairpin domain BHD2; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135:SF3; DNA REPAIR PROTEIN RAD4; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054466}.
FT DOMAIN 480..538
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 540..603
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 610..684
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 1..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 849..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..1009
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1026..1042
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1067 AA; 117741 MW; 7A3598ADB8A401DC CRC64;
MPRRASQPAA RASRPTRRSA RQPKKPGDDI PEVYGDMLAD AVAEEQASAS NSRATKRRKI
SEEPSTQIEL DFDLFGSRTD AQDDGGTAPA DYAPPKIQQV VFDDFEDSDE SDAEFEDVDL
EATTNHAVED RLLEQKTLEL DLSKTSTPRR AIQRRKPVSL AERKLRLDVH KAHLVFLLAH
LNCRNRWCNS EFVHSLLKPL VPRKVISLLH VDESKPQYQR SHSFNKGIEE VCALWRQQWK
ITARGMNRAH WREDVDAVKE SDDAEDLVDF DDFKAAAVSR SGSRDLGAQL FCALLRSVAV
DARLVCSLQV LPFSGIAKGQ TPEKPKPQYI YAPPQNFGSG TQDRNVTTTR ERTPTPKKKR
IVESPFPIFW VEVLSPSVQT WIPLDPLVRN TINKPKTGFE PPASDQLNSM TYVIAFEDDD
SARDVTRRYT QWYNAKTRKQ RVESTKGGDK WWEVTMNLFQ KPFSETRDEI EDASLLKRAE
SEPMPKNIQD FRGHPVYVLE RHLRLNEVIH PRHEVGKVSS GPLKSAKLES VFRRRDVHVC
RTADAWYRRG RDVNEGEQPL KRVVPKRQRN LDAATAEDLD DEDEAQEGMA LYAEFQTSLY
EPPPVVDEKI PRNAYGNLDV YVPSMIPAGA VHIRHPLASA AARVLEINYA DAVTGFQFKG
RQGTAVIDGV VVSMNMTNAM INVIEGLEAQ ATEEVQEART KIILAMWKRW LTALRVHEHV
HRQYGNQKHF SIHKDANAEE DATYRDEEDG GGFMLDQAEL DESEDAANTV PSTPPNLKPL
NQLLPAEVVH QDVIVVRSPN KLAQLPFSDL SRRRDRVVAE PPNADESGGF LHEADDAGGG
FISDDDMDQN VGESQNHGHA ASLHGNISHD GGGRFIFEED NEGGGFLPED EDGDDESQPR
SRAAHGDSIK PEAVATLSEA EHTSTEERLK DAAGAAGNAT AAAAGDSSAK PRSITAEGVG
GSSEDVEPST HSKHIPDAAM ALSAQSLSGT ATLQPKQPTA RSGETTSGQG EGGADHARDP
ALQSPGSGPG SGSRSGSASI AGSLLSHDPE DDDAEPEWLL SSLGEMD
//
