ID A0A0D1ZH78_EXOME Unreviewed; 516 AA.
AC A0A0D1ZH78;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 03-MAY-2023, entry version 33.
DE RecName: Full=DHHA2 domain-containing protein {ECO:0000259|SMART:SM01131};
GN ORFNames=PV10_04397 {ECO:0000313|EMBL:KIV93159.1};
OS Exophiala mesophila (Black yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=212818 {ECO:0000313|EMBL:KIV93159.1, ECO:0000313|Proteomes:UP000054302};
RN [1] {ECO:0000313|EMBL:KIV93159.1, ECO:0000313|Proteomes:UP000054302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 40295 {ECO:0000313|EMBL:KIV93159.1,
RC ECO:0000313|Proteomes:UP000054302};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala mesophila CBS40295.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KN847522; KIV93159.1; -; Genomic_DNA.
DR RefSeq; XP_016224733.1; XM_016368945.1.
DR AlphaFoldDB; A0A0D1ZH78; -.
DR STRING; 212818.A0A0D1ZH78; -.
DR GeneID; 27322242; -.
DR VEuPathDB; FungiDB:PV10_04397; -.
DR HOGENOM; CLU_019358_1_0_1; -.
DR OMA; IKIGICS; -.
DR OrthoDB; 1342473at2759; -.
DR Proteomes; UP000054302; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016462; F:pyrophosphatase activity; IEA:InterPro.
DR Gene3D; 3.10.310.20; DHHA2 domain; 1.
DR Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 1.
DR InterPro; IPR001667; DDH_dom.
DR InterPro; IPR038763; DHH_sf.
DR InterPro; IPR004097; DHHA2.
DR InterPro; IPR038222; DHHA2_dom_sf.
DR PANTHER; PTHR12112; BNIP - RELATED; 1.
DR PANTHER; PTHR12112:SF39; EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN); 1.
DR Pfam; PF01368; DHH; 1.
DR Pfam; PF02833; DHHA2; 1.
DR SMART; SM01131; DHHA2; 1.
DR SUPFAM; SSF64182; DHH phosphoesterases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054302}.
FT DOMAIN 336..512
FT /note="DHHA2"
FT /evidence="ECO:0000259|SMART:SM01131"
FT REGION 235..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 516 AA; 56916 MW; 93AA4F895F6EF677 CRC64;
MASTDSVMPS LSSYLSLIRK AAFQSPRPSA APTLILGNPS ADLDSFVSAI LLSYFYNCNS
QSQDRQRRQQ HLSPGYIPIL NLPTVASSDL WRLRPEFGVA IRLALGHSTA EIDVCEDHAD
QSKVPELEQV VTIADVKKHR DSNLIPARLF SNSDKDSNEG QQQRLLLVDH NAPSIPGLSE
SAIRSRFTVM GVIDHHVDED YVSKKPEDTN PRIITTGIGS CTSLVVQHLR DEGMWPSPDN
FSKDSKSSHK NSSEGDKEGA GQLSTEKPLE QLAKLALAPI LIDTANLLAT GDKCSDTDRC
AVRFLESFIL APAAHSNLST TTNDAQGSHW DRDSFYSCIS TTKTNSLDLL TTQETFDRDY
KSWSEAQVHS QAHDKSAPQI EIGIASLVRP LSWLVTHGPA PSTVKSFVAE MRTFATAEER
RLGVFMLLTR REDGGKELVL AVLDDAGRGL VHDFETKAGP ELQLRAWATK KGDWEASVPQ
ELRANFVDAA VWDMRDTSKS RKQVGPLVRQ CVRELK
//
