ID A0A0D1ZHS2_9EURO Unreviewed; 1083 AA.
AC A0A0D1ZHS2;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 13-SEP-2023, entry version 27.
DE RecName: Full=SPX domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PV11_01995 {ECO:0000313|EMBL:KIV86383.1};
OS Exophiala sideris.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=1016849 {ECO:0000313|EMBL:KIV86383.1, ECO:0000313|Proteomes:UP000053599};
RN [1] {ECO:0000313|EMBL:KIV86383.1, ECO:0000313|Proteomes:UP000053599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 121828 {ECO:0000313|EMBL:KIV86383.1,
RC ECO:0000313|Proteomes:UP000053599};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala sideris CBS121828.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family.
CC {ECO:0000256|ARBA:ARBA00009665}.
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DR EMBL; KN846951; KIV86383.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D1ZHS2; -.
DR STRING; 1016849.A0A0D1ZHS2; -.
DR OrthoDB; 7162at2759; -.
DR Proteomes; UP000053599; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd14475; SPX_SYG1_like; 1.
DR InterPro; IPR004342; EXS_C.
DR InterPro; IPR004331; SPX_dom.
DR PANTHER; PTHR10783:SF103; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1; 1.
DR PANTHER; PTHR10783; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED; 1.
DR Pfam; PF03124; EXS; 1.
DR Pfam; PF03105; SPX; 1.
DR PROSITE; PS51380; EXS; 1.
DR PROSITE; PS51382; SPX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053599};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 542..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 575..595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..641
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 653..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 801..825
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..483
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT DOMAIN 734..928
FT /note="EXS"
FT /evidence="ECO:0000259|PROSITE:PS51380"
FT REGION 44..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 925..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1001..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..426
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..948
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1002..1029
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1030..1045
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1083
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1083 AA; 123789 MW; FEA23A3D7080DA3E CRC64;
MKFAKELEDE AVPEWRIKYL DYKQGKKKIK AVSKALRNLD KTPVLPAAPA LVPENESDRI
PFTQYDFHRP PPSTVRSSRS LPEIEEIAPE DESDHNERPS NARQETRTPL HQSPPIAIPR
QESEHGDVAE RSPLHGGEIF PPTRRQMNYG SIIGSPPSDD TPGRFDALNL PAPAISPASR
NNTHTQTEPP SPQPLSRLPP AAQVPQGSDA YHVGETVRKP RHSLGGSLAR SMFKNRLPPK
MTKSQSVSLP SPSNPNPRSR LRRLFSAQPN EQPVVDDVRL EAYKELDTRQ AEFFSFLDKE
LDKIESFYKM KEDEATARLQ VLRQQLHEMR DRRLAEILQE QHKKGSAAQN GHHDAPAKSI
PSFSGLHPTN GAAADFLKKP LENALGRRSI GKTSQAMKQL SSPPGPKAQE RIGDGKQDYV
RRDHGHDVPY RTAKRRLKLA LQEFYRGLEL LKSYAIVNRT GFRKINKKYD KAVQARPALR
YMSEKVNHAY FVNSDIIDHL LIAVEDLYTR YFERGNHKIA VRKLRSRLGP GDQSGTTFRN
GLYVAAGICF GVTGLVNAAH LLRSPDPTIS TQTSYLLQIY AGYFLSLLLF LLFSLDCRIW
TMSHVNYVFI FEYDTRHVLD WRQLAEIPCF FLFLNGLFLY LNFEITYFES FFLYWPVILI
SITLVIMGLP FKILYYESRR WWGYSNWRLL CAGFYPVEFR DFYLGDMYCS ETYAMGQIEA
FFCLYVNDWN NPPQCNSSHS RLMGFFSALP AVWRALQCLR RYYDSRNWFP HLANCAKYFC
NIVYYMTLSM YRIDISDRTK AIFITFALIN GLYCSFWDVF LDFSLGNPSA KHPFLRDQLA
YKKVWVYYAA MILDVALRQQ WILYAIFTSN VQHSSTVSFL VALAEVLRRG IWSLFRVENE
HCNNVGKFRA SRDIPLPYEI PESPEVASKA ASPIQQRQTP STPGEVRPQL HLTTGVDLEH
ASPGEWSLRN RKAKTPGGGA TPLTPGMRAL QRVGTAIASA HAQDFEKRRK PDVEGPDGQD
EHAYSNRHDS DDDDEDDDDS DDGGVDEVEE LRRQQREDVD SDQRDITEAQ RLVHRARDAD
EGG
//
