ID A0A0D1ZKV5_EXOME Unreviewed; 915 AA.
AC A0A0D1ZKV5;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PV10_02270 {ECO:0000313|EMBL:KIV94509.1};
OS Exophiala mesophila (Black yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=212818 {ECO:0000313|EMBL:KIV94509.1, ECO:0000313|Proteomes:UP000054302};
RN [1] {ECO:0000313|EMBL:KIV94509.1, ECO:0000313|Proteomes:UP000054302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 40295 {ECO:0000313|EMBL:KIV94509.1,
RC ECO:0000313|Proteomes:UP000054302};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala mesophila CBS40295.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KN847521; KIV94509.1; -; Genomic_DNA.
DR RefSeq; XP_016226083.1; XM_016366565.1.
DR AlphaFoldDB; A0A0D1ZKV5; -.
DR STRING; 212818.A0A0D1ZKV5; -.
DR GeneID; 27320115; -.
DR VEuPathDB; FungiDB:PV10_02270; -.
DR HOGENOM; CLU_008201_1_0_1; -.
DR OMA; RKTWIYE; -.
DR OrthoDB; 1328399at2759; -.
DR Proteomes; UP000054302; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04399; RhoGAP_fRGD2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF17; RHO-GTPASE-ACTIVATING PROTEIN RGD2; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000054302}.
FT DOMAIN 19..448
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 245..314
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 482..689
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 693..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..755
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 915 AA; 101278 MW; 364E119E7253181B CRC64;
MAQDKDNAAK AVAVRPKMPG FTDSFWSADY AGGLGVLFEK LHQGVVENQQ ILSIASMRAD
AEEMYSDRLG DIAPTIDRMA GGFARDDGAS VRKAYEGVRG EMVEATKSHK KIADNIRELV
VNPFSRWCDS HATRIQNSQD DLQAKIKALD RQSDAVKKLR SHYFNKCRLV EDLEEENKMA
FQTAAQESPK PQSPPPKIIL PEDDIDELPI DIGDKSYSPD EVKVLLTRML NVIPLGEFKV
PILGTYQNVS SGSDITDYIQ KHMGAPTVGY AEQIGQDLVD RGFLRLVGNM GNTFANSSRM
KYQWKPRAFK ISGIPEKKII ISRSTTNSSL DALADSPIGN ITETLQTWNP LNNPHPNETP
AQRLKREARE ADDKYKAGVR RLDLLRCNLE ESMMDHLKFL ERCETDRLKA IKSVILDFSG
TISNSIPSFQ SQVDHMMLYQ ETIQPLGDLR YLLENYRTGP FAPKVTPYEN YYGSVDDQTF
GVDLEARARA DRKRVPLVVT SILTFLDNHY PDLEGDEARR NIWLVDVPLA ATHHLRNQIN
NGQAVPREVL EKYEVPIVAS VLKLYLLELP DSLVSSQVYE IIKTIYATTA DATPNPISSD
SIDATPRIKV LQSTLGQLRL NNIATLDAIA THFTRLIDLT SADEAYIVAL AQSLAPCILR
PRLENSLTLE EKHAYRLIRD LFDHKEAIFG ELKRQSSTGG SGPANRSRAV SNANPDESSR
RAHMEARARA ITEQRQRDKS PAPTNRHRRD KSTDGSLGRF PVIASPRPEH GRSPSGVGFP
TKRSSLEVPG SNESSPVQQR NQSAVNANSS VRAEQDSTAN EDDQMPSSPV PILPSTFSGG
GPGPHIPPPL DDDSNDSDTQ SPVPLPKDDK PAATSGSIKR VAAVGRNAPG SLKRTPVPSQ
LQGVQLTDRP MDDFS
//
