ID   A0A0D1ZXX8_EXOME        Unreviewed;       636 AA.
AC   A0A0D1ZXX8;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=Cytochrome b5 heme-binding domain-containing protein {ECO:0000259|PROSITE:PS50255};
GN   ORFNames=PV10_06235 {ECO:0000313|EMBL:KIV91723.1};
OS   Exophiala mesophila (Black yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX   NCBI_TaxID=212818 {ECO:0000313|EMBL:KIV91723.1, ECO:0000313|Proteomes:UP000054302};
RN   [1] {ECO:0000313|EMBL:KIV91723.1, ECO:0000313|Proteomes:UP000054302}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 40295 {ECO:0000313|EMBL:KIV91723.1,
RC   ECO:0000313|Proteomes:UP000054302};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA   Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Exophiala mesophila CBS40295.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR   EMBL; KN847523; KIV91723.1; -; Genomic_DNA.
DR   RefSeq; XP_016223297.1; XM_016371004.1.
DR   AlphaFoldDB; A0A0D1ZXX8; -.
DR   STRING; 212818.A0A0D1ZXX8; -.
DR   GeneID; 27324080; -.
DR   VEuPathDB; FungiDB:PV10_06235; -.
DR   OrthoDB; 1605658at2759; -.
DR   Proteomes; UP000054302; Unassembled WGS sequence.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR   InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR   InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR   InterPro; IPR003953; FAD-binding_2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR010960; Flavocytochrome_c.
DR   InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR   NCBIfam; TIGR01813; flavo_cyto_c; 1.
DR   PANTHER; PTHR43400; FUMARATE REDUCTASE; 1.
DR   PANTHER; PTHR43400:SF8; HYPOTHETICAL FUMARATE REDUCTASE (EUROFUNG); 1.
DR   Pfam; PF00173; Cyt-b5; 1.
DR   Pfam; PF00890; FAD_binding_2; 1.
DR   SMART; SM01117; Cyt-b5; 1.
DR   SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR   PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE   4: Predicted;
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054302}.
FT   DOMAIN          552..628
FT                   /note="Cytochrome b5 heme-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50255"
FT   REGION          494..542
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        506..525
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   636 AA;  68985 MW;  7FB0AEEE51C36D18 CRC64;
     MTPPRVIVVG GGLSGLSAAH TVYLNGGNVI VLDKNNFFGG NSTKATSGIN GALTRTQVDH
     GIGDSVKQFY EDTLKSARDK ARPDLIKVLT YQSASAVEWL QDVFNLDLTL VSRLGGHSFP
     RTHRGHDAKF PGMAITYALM QRLEELTEAE PERVEVIKKA KVTKLNKEGN LITGVTYEFD
     GQEHTVDGVV ILATGGYAAD FTETSLLKKH RPDTFDLSST NGTHATGDGH KMLMAIGAND
     IDMDKVQVHP TGLVDPKDPG SKWKFLAAEA LRGEGGILIN NEGKRFCDDL GHRDYVSGKM
     WEEKEKGKWP IRLVLNSKAS NILDFHTRHY SGRGLMKKMS GDELAKEIGI SRSALEASFS
     DYNAIAKGDK KDEWNKKYFH NLPFNVDDTF HVAVMEPVLH FTMGGMEIND KAQVLNKEQK
     PFDALFACGE LAGGVHGANR LGGSSLLGCV VYGRVAGASA SQYLFQKLTA GGVTTASQRA
     GQISLHIDPN TPGKISVEWG SGGSGGASAS VGTAATSQQA QKTAAPVMDG NKGEDPAKKK
     EANDISSFKV PDKEFSLEEV AKHNKKDDLW IAVKGIVMDV TNWLDEHPGG PQALFSHMGR
     DASEEFEMLH DDEVIPKYAA DIVIGRVQGQ EVRLEY
//