ID A0A0D2A8F1_9EURO Unreviewed; 480 AA.
AC A0A0D2A8F1;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=PV08_01616 {ECO:0000313|EMBL:KIW21037.1};
OS Exophiala spinifera.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=91928 {ECO:0000313|EMBL:KIW21037.1, ECO:0000313|Proteomes:UP000053328};
RN [1] {ECO:0000313|EMBL:KIW21037.1, ECO:0000313|Proteomes:UP000053328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 89968 {ECO:0000313|EMBL:KIW21037.1,
RC ECO:0000313|Proteomes:UP000053328};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala spinifera CBS89968.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; KN847492; KIW21037.1; -; Genomic_DNA.
DR RefSeq; XP_016241253.1; XM_016375977.1.
DR AlphaFoldDB; A0A0D2A8F1; -.
DR STRING; 91928.A0A0D2A8F1; -.
DR GeneID; 27328699; -.
DR VEuPathDB; FungiDB:PV08_01616; -.
DR HOGENOM; CLU_009834_22_0_1; -.
DR OrthoDB; 3639304at2759; -.
DR Proteomes; UP000053328; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000053328}.
FT DOMAIN 31..384
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
FT REGION 461..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 480 AA; 53178 MW; 2F3C9A5DC154D35E CRC64;
MSSSPTRYGA MPKELPSDDP DDVLFNSLYG VRTIELNRPK KLNSLNGSMA RKILPRLREW
EKSQMANVIM ITGAGPKAFC AGGDVAELAQ QNKEGPEGQK KSTDYFGLEY QLDHLIATYS
KPYIAVMDGI TMGGGVGLSV HAPFRIATEK TVFAMPETTI GFFPDVGGSF FLSRLDGEIG
TYLALTSERL QGVQAFYAGI ATHYLDSSLL PQLTTRLSEL VFRDYASLSE RLDLINSTIA
EFTSSLPSPD LGKGSSHGDL SGKLREAIDR TFKHDTVEDI LSALGQEAQS GDEYISSWAK
QTQKTIALRS PTSLRVTLRQ LREGKNWNIS ETFIREHRMA AKFMAHPDFV EGVSARLINK
PPTQPVWKPA SLAEVSKEDV DEFFTIPPEF EPLALLEPQE GALDQHFKEY PHSVFALPSE
ADIEQLVRAY GHDGPKAVIQ AVVSRWNNKV GVREKVQEVL ARKTKPEDKG ISWKPQMPSL
//
