ID A0A0D2AI29_9EURO Unreviewed; 629 AA.
AC A0A0D2AI29;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Beta-hexosaminidase {ECO:0000256|PIRNR:PIRNR001093};
DE EC=3.2.1.52 {ECO:0000256|PIRNR:PIRNR001093};
GN ORFNames=PV07_10251 {ECO:0000313|EMBL:KIW24542.1};
OS Cladophialophora immunda.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Cladophialophora.
OX NCBI_TaxID=569365 {ECO:0000313|EMBL:KIW24542.1, ECO:0000313|Proteomes:UP000054466};
RN [1] {ECO:0000313|EMBL:KIW24542.1, ECO:0000313|Proteomes:UP000054466}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 83496 {ECO:0000313|EMBL:KIW24542.1,
RC ECO:0000313|Proteomes:UP000054466};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Cladophialophora immunda CBS83496.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231,
CC ECO:0000256|PIRNR:PIRNR001093};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285, ECO:0000256|PIRNR:PIRNR001093}.
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DR EMBL; KN847045; KIW24542.1; -; Genomic_DNA.
DR RefSeq; XP_016244758.1; XM_016397567.1.
DR AlphaFoldDB; A0A0D2AI29; -.
DR STRING; 569365.A0A0D2AI29; -.
DR GeneID; 27349445; -.
DR VEuPathDB; FungiDB:PV07_10251; -.
DR HOGENOM; CLU_007082_0_2_1; -.
DR OrthoDB; 178991at2759; -.
DR Proteomes; UP000054466; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR029019; HEX_eukaryotic_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF56; BETA-HEXOSAMINIDASE; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF14845; Glycohydro_20b2; 1.
DR PIRSF; PIRSF001093; B-hxosamndse_ab_euk; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|PIRNR:PIRNR001093};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR001093};
KW Reference proteome {ECO:0000313|Proteomes:UP000054466};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..629
FT /note="Beta-hexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002238414"
FT DOMAIN 18..198
FT /note="Beta-hexosaminidase eukaryotic type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14845"
FT DOMAIN 224..583
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 384
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
SQ SEQUENCE 629 AA; 70859 MW; 1FF49D83E2A8A591 CRC64;
MQPRLLLLLG SITACLAVWP QPAEIQTGNR VLWLDAAIHA TLRCEEQTID LYGTSSSQGI
HLASVLNGAL GLTQGLMDKL QFTFVNRNNS AEHGFSERSI VQNSVRETIR SIQQSRFVPW
KLYRRHSTFE PDPHGPRHYI STLQIQQKDC PGPEPLRPQS YFGGDESYVI DIDDHGIASI
KSNCSIGTIR ALQTLKQLFF AHSTKSGSYT PFAPLSIADR ARWRHRGLSI DIARNPFAPK
DLIRTIDAMA MAKLNRLHIH ATDSQSWPLE IPSLPDLARK GAYQPHHVWG ADSLREIQMY
GAEKGVSVFI EIDMPGHTAS VAYAFPNLIA AFNELDWSTF AAEPLSGQLK LNSSDVHKFV
ATVLDDLLPR TRPYTSLYHI GGDELNLAAY LLDETVQSDD PRVLQPLLQK FIDNVIEASI
RHGLQPIVWE EMLLDWNLTL PSALDSAPSR QTLVQVWRNS ERIEEVLKRG HRAIFGDYHY
WYLDCGFGVF LDPYPSGKSP PGVPYNTSGG YSSRLQKPYL DYCNPYHNWR QMYTYNPLAN
ISVDLQEGIE GGEVLMWSEQ TDSSDLDSKL WPRAAAAAEV LWAGVRDESM LENATRRLGE
WRERGVRDLG LRMSPVTMTW CLMEGGCNL
//
