ID A0A0D2ATV3_9EURO Unreviewed; 898 AA.
AC A0A0D2ATV3;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Beta-mannosidase B {ECO:0000256|ARBA:ARBA00041069};
DE EC=3.2.1.25 {ECO:0000256|ARBA:ARBA00012754};
DE AltName: Full=Mannanase B {ECO:0000256|ARBA:ARBA00041614};
GN ORFNames=PV08_11696 {ECO:0000313|EMBL:KIW09920.1};
OS Exophiala spinifera.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=91928 {ECO:0000313|EMBL:KIW09920.1, ECO:0000313|Proteomes:UP000053328};
RN [1] {ECO:0000313|EMBL:KIW09920.1, ECO:0000313|Proteomes:UP000053328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 89968 {ECO:0000313|EMBL:KIW09920.1,
RC ECO:0000313|Proteomes:UP000053328};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala spinifera CBS89968.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing beta-D-mannose residues
CC in beta-D-mannosides.; EC=3.2.1.25;
CC Evidence={ECO:0000256|ARBA:ARBA00000829};
CC -!- PATHWAY: Glycan metabolism; N-glycan degradation.
CC {ECO:0000256|ARBA:ARBA00004740}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family. Beta-
CC mannosidase B subfamily. {ECO:0000256|ARBA:ARBA00038429}.
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DR EMBL; KN847501; KIW09920.1; -; Genomic_DNA.
DR RefSeq; XP_016230136.1; XM_016386004.1.
DR AlphaFoldDB; A0A0D2ATV3; -.
DR STRING; 91928.A0A0D2ATV3; -.
DR GeneID; 27338779; -.
DR VEuPathDB; FungiDB:PV08_11696; -.
DR HOGENOM; CLU_005015_1_1_1; -.
DR OrthoDB; 2091382at2759; -.
DR Proteomes; UP000053328; Unassembled WGS sequence.
DR GO; GO:0004567; F:beta-mannosidase activity; IEA:UniProt.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR041447; Mannosidase_ig.
DR PANTHER; PTHR43730; BETA-MANNOSIDASE; 1.
DR PANTHER; PTHR43730:SF1; BETA-MANNOSIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF17786; Mannosidase_ig; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000053328}.
FT DOMAIN 220..325
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 706..776
FT /note="Mannosidase Ig/CBM-like"
FT /evidence="ECO:0000259|Pfam:PF17786"
SQ SEQUENCE 898 AA; 101592 MW; 040B99BE0BCF7827 CRC64;
MLRKVIELSS GWRYRAVDES SSSPPTATSI WRTCRSLPTE IHLDLLNDNL IPDPFIGKNE
EALQWVGETK WEYETNLTVP ADALVPESRT VLVMEGLDTF ATVTLNGKPI LQSANAFMTH
RVGLTRDMFE TNEGSNLPSS CNDHDESSVT GILRIVFANA EQCGLEIVKQ HAEHGWFSLG
SSITRLATRK PQYHYGWDWG PKIMTCGPWR PIYVEYYTSR IADVAISSSL SADLQEAIVE
VSVEVDGLAE HFVMDLLLHG NVVHHEVVPV RERIGRIQMK LATPQLWWPH SLGPATMYSV
QLSLYATQDA EFLIVDQTEK SFGIRKVELV QRGLEDQDGD SFFFKVNNIP IFAAGSCWIP
ADSFLSRISP RRYQDWIQLA RDCNQNMIRV WGGGIYENPA FYEACDRQGM LVWQDFMFAC
GSYPVHEEFR RQIVAEAEQN VRRLRHHPCL VLWCGNNEDY VIYPLRGIQY DATETSPEAM
FKSILPARYF YEHVLPTICA DLNPGTPYWP GSPFGGAMVN SPLEGDIHQW HVWHFEMFPY
QDFSRLSGRF VSEFGMQALP CLETAKEFFP VEGPCTASET DVLDNQFLKW HNKMADGHDR
LRHYGRANIS FGTSALDDVI YNTQLIQAEA VATAYRSWRR LWQGPGKEYC SGALVWQLND
CWPVTSWAIV DYHLRPKMAY WAMKRECAFV TGGLSRITKN GGALALDYWA VNMTQNEVKA
SVTIRAWLVG TGEQVLEQQL HDSVSLQPNR SVDLGILGVD DLKLPTIQQY RDIVFALVVE
LTETEENLPK TVQAVNFHDP LREVPFPSYN AKVDVAISQS AAGISVRARA TVPMKGLLFE
VDGDPNAKWD DNGIDLIPGQ IAELRYLGQG LRPGQESRLR ARWLGGSLDQ LSHLRPSL
//
