ID A0A0D2ATW9_9EURO Unreviewed; 847 AA.
AC A0A0D2ATW9;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=HRDC domain-containing protein {ECO:0000259|PROSITE:PS50967};
GN ORFNames=PV07_08305 {ECO:0000313|EMBL:KIW28662.1};
OS Cladophialophora immunda.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Cladophialophora.
OX NCBI_TaxID=569365 {ECO:0000313|EMBL:KIW28662.1, ECO:0000313|Proteomes:UP000054466};
RN [1] {ECO:0000313|EMBL:KIW28662.1, ECO:0000313|Proteomes:UP000054466}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 83496 {ECO:0000313|EMBL:KIW28662.1,
RC ECO:0000313|Proteomes:UP000054466};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Cladophialophora immunda CBS83496.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
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DR EMBL; KN847043; KIW28662.1; -; Genomic_DNA.
DR RefSeq; XP_016248878.1; XM_016395459.1.
DR AlphaFoldDB; A0A0D2ATW9; -.
DR STRING; 569365.A0A0D2ATW9; -.
DR GeneID; 27347499; -.
DR VEuPathDB; FungiDB:PV07_08305; -.
DR HOGENOM; CLU_010129_0_1_1; -.
DR OrthoDB; 2880475at2759; -.
DR Proteomes; UP000054466; Unassembled WGS sequence.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000054466};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 441..521
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 535..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 847 AA; 94438 MW; B9F9443BF93FC965 CRC64;
MDLTADFKSF QDLVQASLIN VTRSATQVSN QDLGFHRSSC DKLSRALDRQ DAHLLRLTSK
LLKAAAQDTP LKPPTLQNQD SVEDNWRGIV DVVDGLLEKA DSALDEFSGI IKPQEVTRQD
ADSPRPSKTG LGFQRWAATN IPKPQVFFDR QVNNSDSTPF KPLLQTKPHA IVPLEESLGD
EDTGYNHPYE RELTDYKYPP SVYKFKQPIA FTPIDESEHI FVDTEEGVIE MLEELKGAEE
IAIDLEHNDM RSYVGLVCLM QISTREKDWI VDTLKPWREK LQMLNQVFAD PKILKVLHGS
SMDVIWLQRD LGLYVVGLFD TYHAACALQF QGKGLKHLLL QFANVHAQKQ YQLADWRVRP
LPKELIDYAR SDTHYLLTIY DHMRNMLVNG SSANVNLTDY VLTQSKKEAL QVYSRQLYDL
ETGGGPLGWF GLLTQRFVNL SKEQLGVFRA LHAWRDRKAR EMDEGIQYIL PNRTLWLVAE
NMPTSVFNFH QSCRGDSKLV SDRIPEIIEI VKQGKVEGKN GKSHAEVVQH CEKTLGPTAR
RPREKKQQPQ STYSGLGATL KQLAATPALT PLDHDELVPT VNRSSASIFW GDVTPQYQQT
PTDVATAVAA LSSIVPLRLL AVEDAEKGEE NLAQLISTQA QTETWIEPTK KLDPWPATPK
DQLRSKANEI FSLNELSRSK GKKRKTDEFN EDINDNELAV LVSSSGAING TTAASEVAVP
TSASPSQTPQ NTDAERNPEF EAKRQAKKQK KAEKKARKEA AKAAAEAELQ ATQPFDYGSA
PSLLNPGPQP SSQLGSGGGT AEGRGQGQQV PQKKIMNPFA KALDTSTGAR RGKMSKELQG
KSMTFNS
//
