ID A0A0D2AUU4_9EURO Unreviewed; 1123 AA.
AC A0A0D2AUU4;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=ISWI chromatin-remodeling complex ATPase ISW2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=PV06_04637 {ECO:0000313|EMBL:KIW43546.1};
OS Exophiala oligosperma.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=215243 {ECO:0000313|EMBL:KIW43546.1, ECO:0000313|Proteomes:UP000053342};
RN [1] {ECO:0000313|EMBL:KIW43546.1, ECO:0000313|Proteomes:UP000053342}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 72588 {ECO:0000313|EMBL:KIW43546.1,
RC ECO:0000313|Proteomes:UP000053342};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala oligosperma CBS72588.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
CC {ECO:0000256|ARBA:ARBA00009687}.
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DR EMBL; KN847335; KIW43546.1; -; Genomic_DNA.
DR RefSeq; XP_016263762.1; XM_016405556.1.
DR AlphaFoldDB; A0A0D2AUU4; -.
DR STRING; 215243.A0A0D2AUU4; -.
DR GeneID; 27356711; -.
DR VEuPathDB; FungiDB:PV06_04637; -.
DR HOGENOM; CLU_000315_0_2_1; -.
DR OrthoDB; 5482994at2759; -.
DR Proteomes; UP000053342; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0031491; F:nucleosome binding; IEA:InterPro.
DR CDD; cd17997; DEXHc_SMARCA1_SMARCA5; 1.
DR CDD; cd00167; SANT; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.10.1040.30; ISWI, HAND domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR044754; Isw1/2_DEXHc.
DR InterPro; IPR015194; ISWI_HAND-dom.
DR InterPro; IPR036306; ISWI_HAND-dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR015195; SLIDE.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR PANTHER; PTHR45623:SF49; SWI_SNF RELATED, MATRIX ASSOCIATED, ACTIN DEPENDENT REGULATOR OF CHROMATIN, SUBFAMILY A, MEMBER 1; 1.
DR Pfam; PF09110; HAND; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF09111; SLIDE; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF101224; HAND domain of the nucleosome remodeling ATPase ISWI; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51293; SANT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053342}.
FT DOMAIN 209..374
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 505..656
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 864..916
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 823..853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1041..1123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1041..1060
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1093..1116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1123 AA; 128542 MW; 7A2EE3C85ECA5298 CRC64;
MAPIKPQQTD SENSSVADIS MTDAHSIIQP RRPSFGHLNR YMDDTPDYTD SDTNPNTTTS
SVAGDIVAPD GRKRRSEAFQ LRKSILGRKH GQLDESKEDD TIRRFKYLLG LTDLFRHFIE
TNPNPKIRDV VEEIDRQNAD DAAKAKKGVS RKGGAAAGAK RKTEQEEDAE LLRDEKRGTA
SQTIFRDSPA FIQGGEMRDY QVAGLNWLIS LHENGISGIL ADEMGLGKTL QTISFLGYLR
HICDIKGPHL IAVPKSTLDN WAREFKKWTP EVDVLVLQGA KDDRHALIQD RLIEEKFDVC
ITSYEMILRE KSHLKKFAWE YIIVDEAHRI KNEESSLAQI IRMFTSRNRL LITGTPLQNN
LHELWALLNF LLPDVFGDSE AFDSWFSSQN DDQDTVVQQL HRVLRPFLLR RVKSDVEKSL
LPKKEVNLYV GMSEMQVKWY QRILEKDIDA VNGAGGKRES KTRLLNIVMQ LRKCCNHPYL
FEGAEPGPPY TTDEHLVYNS GKMIILDKIL NRMKEEGSRV LIFSQMSRVL DILEDYCVFR
GHKYCRIDGG TAHEDRIAAI DDYNKPDSEK FVFLLTTRAG GLGINLTTAN IVVLYDSDWN
PQADLQAMDR AHRIGQTKQV RVFRFVTENA IEEKVLERAA QKLRLDQLVI QQGRAQQQVK
QAASKDDLLN MIQHGAEKVF ETKGATGALD DIDEILQRGE ARTAELNKKY EKLGIDDLQK
FSSENAYEWN GEDFTQRRKD IAVSWINPAK RERKEQFYSV DKYYKQALST GGGKPAEPKP
KVPRAPKQVN VHDWQFFPPG LQELQEKETA YYHKEIGYKV PLADGTEEDL SDREADQRLN
QDEIDNAEPL TEEEKQKKAE MQEHGFGNWN RRDFQQFING SAKFGRNNYE GIANEVDSKE
PDEIEEYAKV FWKRYTEIAD YDKHIKTIEA GEEKLRKTNL QRKLLRKKME MYRVPLQQLK
INYTVSTTNK KVYTEEEDRF LLVMLDKHGV DGEGLYDKIR DEIRESPLFR FDWFFLSRTP
VEIGRRCTTL LNTVLREFGD PEEKLTNGHG SGKGRGRDRD DEEDEDNDSE AAPVKKKAKN
GIVNKAVKAV KSGRGSKNTS PATSRAQSVS STAPASKSKG KKK
//
