ID A0A0D2BNI0_9EURO Unreviewed; 1138 AA.
AC A0A0D2BNI0;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Exportin-T {ECO:0000256|ARBA:ARBA00018928, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=Exportin(tRNA) {ECO:0000256|RuleBase:RU366037};
DE AltName: Full=tRNA exportin {ECO:0000256|RuleBase:RU366037};
GN ORFNames=PV08_00660 {ECO:0000313|EMBL:KIW20085.1};
OS Exophiala spinifera.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=91928 {ECO:0000313|EMBL:KIW20085.1, ECO:0000313|Proteomes:UP000053328};
RN [1] {ECO:0000313|EMBL:KIW20085.1, ECO:0000313|Proteomes:UP000053328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 89968 {ECO:0000313|EMBL:KIW20085.1,
RC ECO:0000313|Proteomes:UP000053328};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala spinifera CBS89968.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex. Involved in pre-tRNA
CC splicing, probably by affecting the interaction of pre-tRNA with
CC splicing endonuclease. {ECO:0000256|ARBA:ARBA00025147}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU366037}. Nucleus
CC {ECO:0000256|RuleBase:RU366037}. Note=Shuttles between the nucleus and
CC the cytoplasm. {ECO:0000256|RuleBase:RU366037}.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|ARBA:ARBA00009466, ECO:0000256|RuleBase:RU366037}.
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DR EMBL; KN847492; KIW20085.1; -; Genomic_DNA.
DR RefSeq; XP_016240301.1; XM_016375025.1.
DR AlphaFoldDB; A0A0D2BNI0; -.
DR STRING; 91928.A0A0D2BNI0; -.
DR GeneID; 27327743; -.
DR VEuPathDB; FungiDB:PV08_00660; -.
DR HOGENOM; CLU_004414_0_1_1; -.
DR OrthoDB; 2546268at2759; -.
DR Proteomes; UP000053328; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952:SF11; EXPORTIN-T; 1.
DR PANTHER; PTHR15952; EXPORTIN-T/LOS1; 1.
DR Pfam; PF19282; Exportin-T; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU366037};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366037};
KW Reference proteome {ECO:0000313|Proteomes:UP000053328};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU366037};
KW Transport {ECO:0000256|RuleBase:RU366037};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555,
KW ECO:0000256|RuleBase:RU366037}.
FT DOMAIN 214..376
FT /note="Exportin-1/Importin-beta-like"
FT /evidence="ECO:0000259|Pfam:PF08389"
FT DOMAIN 451..1134
FT /note="Exportin-T C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19282"
SQ SEQUENCE 1138 AA; 126353 MW; 3AF1696EDFD8A6F3 CRC64;
MAWDEQEVPR LKAARRNAKA GMISHGPATT ATTVYLQAIF CFGKSDTSPR ASRDTRAIYS
KKIFPPSSPW NSPGSTCFPL SFIPHAVTTS FDQCSGLDQV GEEHWHYLMD DQIISAIQIA
YSPTSDPTLK RQAFDYVNQL RQEPSAWQPC LSISLQVPRQ PMVIRIFCLE IVNNALQAGL
VDQAGLKIIK DQLMAYLHKF YGSSTEEETP DPGTILNKFA QTVTLLFAAF YGSGWETCFD
DLLALTSNET GTRYNYPGVV FYLTVLNSIH DEIGDVLLSR SPDEQERAST LKDLVRERDV
QKIAGSWQEI LSQWRSSNDV VAELCLKAVG KWVSWVDISL VVNQQMLELL FHQLERAQTV
NPRPGEELAR DAAVDVFTET VAKGMPAADK INMITFLDLE SVVSKLVTCP PLRDSRASNY
DVDLAETVAK LVNTTVADLV KILDTENQGT QTWIKAEQLL EAFLPHLLRF FSDVFDEVCS
TVLTAMNDVL AFLRRTSASS GSDQRAAMLL PILKAIFTKM RYDDTADWNQ EDEQTDEAEF
QDLRKRLASL QATIAGADEQ LYVQAISTLV HETFQRLRTE GSQLDWRDLD LALHELYLLG
DLVGKSGGIQ KSKPNSPAAE NLFRMMLEMV QSNVGSFGHP AIQLQFMEIC VRHSTFFEKQ
TEFIQPVLQN FLQLAHHPSL KVKARAWYLT QRLIRQLRTH LGDATEMVVQ SLQDILVVRA
EIPKESEGDE MSSDNESSAD STFQSQLYLF EAVGCICGAT SAGPDKQAQY VQVVMQPLFS
EIERNLEAAR AGNELANLQI HHSIMALGTI ARGYSDFTPG TAAQPAGSES GAQAKQAFAQ
VAEATLVTLS SLKSSFQIRT AARFAFSRLI GIVGAQMMQQ LPQWVEGLLT ESSTRDEMAL
FLRLLDQVIY SFKNDISDFL DRLFSGLLQR VFAGMSAGTS GTDDEIELAE LKREYLNFLM
IILGNDLGAI LVSATNQPVF ESVISSIEQL ARDVEDFPTA KMAFIVLSRM CTVWGGPDVV
SATGQATGNG AAPQPALPGF DQFMISRFSP LCWALPTNPA FNSKDAQARQ ALSEAAGLQK
TIYLKTGQQY LSWLQENELR TMGMNDSMIA DYLQKLATMD PKGFKAFFAK FIAQGGQL
//
