ID A0A0D2BP36_9EURO Unreviewed; 3807 AA.
AC A0A0D2BP36;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PV08_08056 {ECO:0000313|EMBL:KIW12869.1};
OS Exophiala spinifera.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=91928 {ECO:0000313|EMBL:KIW12869.1, ECO:0000313|Proteomes:UP000053328};
RN [1] {ECO:0000313|EMBL:KIW12869.1, ECO:0000313|Proteomes:UP000053328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 89968 {ECO:0000313|EMBL:KIW12869.1,
RC ECO:0000313|Proteomes:UP000053328};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala spinifera CBS89968.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Serine/threonine protein kinase which activates checkpoint
CC signaling upon genotoxic stresses such as ionizing radiation (IR),
CC ultraviolet light (UV), or DNA replication stalling, thereby acting as
CC a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-
CC Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of
CC DNA damage, involved in the regulation of DNA damage response
CC mechanism. Required for the control of telomere length and genome
CC stability. {ECO:0000256|ARBA:ARBA00025079}.
CC -!- SUBUNIT: Associates with DNA double-strand breaks.
CC {ECO:0000256|ARBA:ARBA00011370}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KN847497; KIW12869.1; -; Genomic_DNA.
DR RefSeq; XP_016233085.1; XM_016382382.1.
DR STRING; 91928.A0A0D2BP36; -.
DR GeneID; 27335139; -.
DR VEuPathDB; FungiDB:PV08_08056; -.
DR HOGENOM; CLU_000129_1_0_1; -.
DR OrthoDB; 3666795at2759; -.
DR Proteomes; UP000053328; Unassembled WGS sequence.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000053328}.
FT DOMAIN 2626..3181
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3431..3763
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3775..3807
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 160..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2003..2032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3193..3261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2003..2029
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3193..3208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3209..3233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3807 AA; 433997 MW; 7329575CB37A646A CRC64;
MDASQKIDHY AARLSDPKTG KSSSQSHLST DLRDSIETLC SPPALFTKFL SKLWPVFKKI
LEGKPDFNPF SFEHILRNQI LEILYRLQHG PPEVEPYALD MVDTLMELVR VENEDNAVLC
LKTIMDLERH QQQATASKVQ PFLDLIQEMF EMMDQVVRDT FDSPAPHSQG SSSTPIPPGQ
NLQSPRPGSP ATTVSDPGAE KREQHPLVKG MQSFKVLSEC PIIVVSIFQA HRNSVPANVK
KFVPSIKGIL LLQAKPQERA HAEAAANKTI FTGVSREIKN RNAFGDFITA QVKTMSFLAY
LLRVYANQLT DFLPSLPAIV VRLLKDCPRE KSGARKELLV AIRHIINFNY RKVFLNKIDE
LLDERILIGN GLTVYETMRP LAYSMLADLI HHVRDSLDRN QIRKTIEVYT KNLHDNFPGT
SFQTMSAKLL LNMAESITKL ENKEDARYFL IMILDAIGDK FAAMNYQYNN AVKLSKQYIE
KAKDTQPESY MDDKNEVPDW DEVDIFNATP IKTSNPRDRG AEPVVDNKFL FKNLVNGLKN
MFYQLKTCNP PGLNVDQASV PMNWAEVSFG YNAEETRVIT KLFHEGARVF RYYSAEAPTP
DLQYSSPVDF MASHSMAQMT REEKELLESF GTVFHCIDPA TFHEVFQAEI PYLHDLMFEH
TALLHLPQFF LASEATSPAF AGMVLQYLMD KLPEVGSSDI VRSSILLRMF KLSFMAVTLF
STHNEQVLLP HITKIITQCV QLSVTAEKPI HYFILLRSLF RSIGGGRFEL LYKEILPLLE
MLLETFNHLL QGARDPHDRD LYVELTLTVP ARLSHLLPHL NHLMRPLVVA LRAGPDLVGQ
GLRTLELCVD NLTADYLDPI MAPIMDELMA ALFEHLQPQP YQHFHSHTTM RILGKLGGRN
RKFLNHPHEL AYRRYTDDEP SFDIRLIETS RDRAFPLDTG VDLAIRRLSD TAKNPSKKSV
DLYYKQQSFK LIVNQVKLLI GFDNLPDDFA ALLRLQANDL VSRRFSTYAD MLADNELGKS
VQKRREQEES LKKLLKACFA ATTIPDLKSQ AESFITNVSR HFTIVELGQA LCDAGRKTKE
FDVNSGEGAV HLSTRTLADV ICHCLASDNV TIREAAEASL LVIVDTARTI FGSEERAARL
PFFSHLISTF CHRCREVEWF TKAGATLSIQ LVITKLALGN AFLHSKQLEI IRALLFVIKD
TPQEFPASTR ITAQETLEFI LRKVCVGQTR EMLVNEKSTI HALSVTFSVE LSHMNKHARE
TAQRAFSTMA EVVGVDVHEL IAPVKERLLQ PIFNKPLRAL PFLSQTGFID AITYCLGLGH
DFVPLNDQLN RLMMESLALA DADAEILHPK PDEYNNAQLI VNLRVSCLKL LSLAMSLPDF
ATGPQNTSRA RIITVFFKLL YSKSPEIIDA ANAGLEKVLV QTAKLPKDLL QNGLRPILMN
LQDSKRLTVA GLEGLARLLT LLTNYFKVEI GARLLEHMKV IAEEQLLQKV SFGLIEQNPQ
MKIVTAIFNI FHLLPSAATS FMADLVDSVL DLESKLRRTV ASPFRQPLIL YLDKYPQETW
AFFSSRLQEE KYGRFFGQIL ASDLSANLRK FVMTESEALT KAAFETEEGQ DGNTAAINGI
YVIHSICSFD AAKDWLREQP QLRAKVLSAG RELEGQLRAD TLQPQQRLRV EQTGDRVMDI
LTSYLSSAPE DLDFMMEVFS ASAQGEIKTP LKLTQYLFGS VITDDSTQRR FNVIDRCLEV
YAQKGISQKV KTFLLHNVVN PIMARDLQNT RRENNQAGSL SDAKLFSLIS DRLWKPLALD
SEDSSQPGID HSRMEALQLS AFILKYHKDA VSEDRKDIIK YTWGHIKLED VINKYAAYVL
ICYFIRAYDT PPRIAVQVYN QLLKAHQNEG KALVTQALEV LAPVLPVRMG ANAPGDNRAP
HWARLPRKIL NEETGNLQQV QSIFNFIVRQ PDLFYESREF FIPTIVQMLH KIAPPPNPSN
ENKKLALSLI GLIHQWESRR ISEGSSVQSN AELTPSRKRD SSGTPNLAPP STAERPEYLI
PIELRTLVVK YMITFITSLL ERYPVPAAEL KAKTMQKAQQ QPLPNEMCKK AVQLLRDLLA
PNLWADVDVG LYEKLLDPIL SGEKADKADE KQLTCMINTL QVMRILLGTK TDEWIVNHME
KIQNLLEKPL KMDDPEIQDC LHFVTDDDKT LPLVRRVLEA IPKQRNEDED TMELDSNPTD
FPTRYSKVLI GEALSSGNYT SAINNLWTLS VVRPAEVDDH IAGAMKALQQ KLAKDHINAY
IIPPGPPPPG WRMGEPLMDP YEFALGVDLI KKTIDILSSR MGELNEQRRP FLSVLASLVE
KSFNVEMCGK VLDMVEKWVF NSSEPWPTLK EKTAVLHKML IFEKWQNQTL LERFLELVIK
IYEDPTVTRT ELTVRLEHAF LIGTRATDVD MRNRFMNIFN RALSRTASYR LNYVLTLQNW
DTLADSFWLK QASHLIMGSV EMSMPARLHP EDIRVCPLSS LFSPSLVNPE QGKDDLLIED
SLEALVLAQR RFNQDIQEVK VRDLLDPITQ LQHTDDNVAY DVWVKLFPLC WSALNRDERL
DLEKGMVTLL TREYHQRQLN LRPNVVQALL EGAVRAKPRF KVPPHVLKFL SRTYDAWYTA
LVSLEESTVD PLIDTPQVRE SNLDALIEVY AGLQEDDLFY GTWRRRCKFM ETNAALSYEQ
HGMWEKAQQL WEAAQVKART GVVPFSQGEY YLWEDHWMIC AQKLQQWDIL GEFAKHENFS
DLLLESAWRN YEAWAGDENR NQLDSMIKSV SDAPTPRRTF FQAFMALLRY NSKQVSRAEF
QHVCDEAIQL SIRKWHQLPR RLTGAHIPIL QNFQQLVELH DASVICDSLM STNERNLDNK
SQEVKLLLQA WRDRLPNIWD DINAWQDLVT WRQHVFQLVN STYLPLLPQG GNNVGNNSYA
FRGYHETAWI INKFAHVARK HQMPDVCINQ LGKIYTLPNI EIQEAFLKLR EQAKCHYQNK
SELNNGLDVI NNTNLNYFGA QQKAEFYTLK GMFLAKLQHA EEANEAFGVA LYYDLRLPKA
WAEWGQYSDR KFKENPSLIE AASNAVSCYL EAAGLYKSAK SRKMLSRVLW LLSLDDEEGH
IAKAFEDFKG ETPVWYWTTF VPQLLGSLEH KEARLAKSVL VKIAKAFPQA LFYNLRATRE
EFLTKKKQFE AQKRQQKAIQ DKLEKSENGS RPGTANGETA TQESASPKPK QEPNGDAQAS
GAVNGVAEAE TKEEPKKPWD HTDEIMAGLK TAFPLLALSM ETMTDQLSKH FKCPPDEDAH
RLIVALLNDG LAYISRAPIT YAEGAKLPPS TEANIARFVT SVLPAHIRKS FEADFVQTKP
TMYEYIHKLR RWRDKFEQKL DHRQQWAALE AYSHHLSEFK FLKFDDSVEV PGQYQQHKDK
NTDFVRIERF MPTVELVRGN SICHRRLTIR GHDGSLHPFA VQHPTGGKVR REERIVQLFR
IFNQTLAKRK ESRRRNLYFH LPIFVPIAPY IRLVQDDASY VTLQSVYEDY VRKAPGMSRD
DPMLFLLEKS RTIAEQQKTQ PRTHDQVAVM KTEIFNTIQE RWVPNTIALR YFQDIYPSFA
DLWLFRRQFA YQFAATTFMT YIMHMSARYP MKFSISRSTG DIWASDLLPN LNSARAYFYN
PEAVPFRLSP NIQTLMGPLA VEGIFTASLM AIARCLAEQD QGYEMEQQLS IFVRDEMYNW
AAGRSNSSND TKMEGQHLRE LVAQNAEFIV RRALALSKTQ GTVGAAGGEG AGVTGVLPAC
QNVVDLVSRA TDPMKLSSMD GLWMPWL
//
