ID A0A0D2BUA5_9EURO Unreviewed; 502 AA.
AC A0A0D2BUA5;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=U-box domain-containing protein {ECO:0000259|SMART:SM00504};
GN ORFNames=PV08_07644 {ECO:0000313|EMBL:KIW14859.1};
OS Exophiala spinifera.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=91928 {ECO:0000313|EMBL:KIW14859.1, ECO:0000313|Proteomes:UP000053328};
RN [1] {ECO:0000313|EMBL:KIW14859.1, ECO:0000313|Proteomes:UP000053328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 89968 {ECO:0000313|EMBL:KIW14859.1,
RC ECO:0000313|Proteomes:UP000053328};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala spinifera CBS89968.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein sumoylation.
CC {ECO:0000256|ARBA:ARBA00004718}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NSE2 family.
CC {ECO:0000256|ARBA:ARBA00008212}.
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DR EMBL; KN847496; KIW14859.1; -; Genomic_DNA.
DR RefSeq; XP_016235075.1; XM_016381973.1.
DR AlphaFoldDB; A0A0D2BUA5; -.
DR STRING; 91928.A0A0D2BUA5; -.
DR GeneID; 27334727; -.
DR VEuPathDB; FungiDB:PV08_07644; -.
DR HOGENOM; CLU_028753_1_0_1; -.
DR OrthoDB; 2726194at2759; -.
DR UniPathway; UPA00886; -.
DR Proteomes; UP000053328; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030915; C:Smc5-Smc6 complex; IEA:InterPro.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0019789; F:SUMO transferase activity; IEA:InterPro.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR GO; GO:0016925; P:protein sumoylation; IEA:UniProtKB-UniPathway.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd16651; SPL-RING_NSE2; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR026846; Nse2(Mms21).
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR004181; Znf_MIZ.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR21330:SF1; E3 SUMO-PROTEIN LIGASE NSE2; 1.
DR PANTHER; PTHR21330; UNCHARACTERIZED; 1.
DR Pfam; PF11789; zf-Nse; 1.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053328};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 278..375
FT /note="U-box"
FT /evidence="ECO:0000259|SMART:SM00504"
FT REGION 127..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..469
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 502 AA; 56227 MW; 4E4CFEFE8B11C053 CRC64;
MATSTIQPQP LTAPLNEDAI ASLQALAKDR TLTTKLAKYL KDASDHLAQT VDQLNEIGYD
RRIRHDRHRK RRNGNDGGHD DADREFEEFQ SKVDTLTNKM DMSIRAIVDN QIWLEDLPNA
IKEAAGRAEL SSTQTQQSYN PTPLSTRRTV PDDDDEEEDD DDDEDHPPRT RNRNSTAQSA
PHAADVPHVL LSAALQKQQR EWSSKTPTEK YAHHNFYAGF KRMLYDALHP GEEQPPMPDP
GLWFAAEEGR DILLSQRVRR GGDDSEESDV EIARETTRIK CPITLLPFQD PVTSEKCKHS
YEKEAIFGML RTSREYALLG ADQLRELSQI PNRVERSRRE REMQIRTVKC PECNVPLTED
DLQPNLALKR RVQRHLALLA KKNRDETATS DVDDDDEDGD GPGVRGARQG TLRRPVGLGS
SPVVASTAKS KKQFKAERLS GVGGRRDPGS ANLHGEDDED DDDDDDEGEG SGSSRLLPGT
PSRNQLPDST MTTTILELGD DD
//
