ID A0A0D2BUY4_9EURO Unreviewed; 537 AA.
AC A0A0D2BUY4;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN ORFNames=PV08_07791 {ECO:0000313|EMBL:KIW15004.1};
OS Exophiala spinifera.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=91928 {ECO:0000313|EMBL:KIW15004.1, ECO:0000313|Proteomes:UP000053328};
RN [1] {ECO:0000313|EMBL:KIW15004.1, ECO:0000313|Proteomes:UP000053328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 89968 {ECO:0000313|EMBL:KIW15004.1,
RC ECO:0000313|Proteomes:UP000053328};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala spinifera CBS89968.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable lipid hydrolase. {ECO:0000256|ARBA:ARBA00002682}.
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DR EMBL; KN847496; KIW15004.1; -; Genomic_DNA.
DR RefSeq; XP_016235220.1; XM_016382118.1.
DR AlphaFoldDB; A0A0D2BUY4; -.
DR STRING; 91928.A0A0D2BUY4; -.
DR GeneID; 27334874; -.
DR VEuPathDB; FungiDB:PV08_07791; -.
DR HOGENOM; CLU_009031_5_0_1; -.
DR OrthoDB; 154387at2759; -.
DR Proteomes; UP000053328; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006641; P:triglyceride metabolic process; IEA:UniProt.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR021771; Triacylglycerol_lipase_N.
DR PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR PANTHER; PTHR14226:SF44; TRIACYLGLYCEROL LIPASE 3; 1.
DR Pfam; PF11815; DUF3336; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000053328};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..537
FT /note="PNPLA domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002239244"
FT DOMAIN 174..366
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
SQ SEQUENCE 537 AA; 60684 MW; C8672AA284C5E788 CRC64;
MNALARCLGE VWTILRYCVL GLWLEPWIKP QSTQDANTAA TYDDWRAWQY TYDAIHGADD
WVNTDRDPSY DWQIVRSLRR DLERCRRLGD DRGLCSQLRA QSSRNMGRIL SPALYLRSQV
QTKRLIHEYI LEVRLCIVQI ANQTSTGNVS TLVSAQEKRQ ALSDMRTALG RTSLVLQGGA
MISMCHFGVV KTLLEQRLLP QIIIGTSTGA LVAALISATP NENLPTVLDS MHINLDSFVR
AESRQINGHF KSWMSSSFLA SAVRRYRRYR TTKHLFDINV LRDCARDNLG DITFEEAYAK
TGRILNITIA MSEVAGTPQL LNYITAPHVL LWSAVTASIA TSKDMYAPVH LFCKSDTGAI
RTHFAADFSE RGCTRQGTAH PEAPLTRIGE LFNVNHFIVS QTRPYVAPFV QIQKFADHHQ
PLGKLVRVCM DELLHWLEVL NSFGLLPTWL QRVLVDEVVP SFASWSKISI TPGIKPGDLF
SLFNNPNAEM LRAWSARGEK CTWPYICELK CRCDIELELD AAYAKVRRRP TIPTAPA
//
