ID   A0A0D2CVE7_9EURO        Unreviewed;       937 AA.
AC   A0A0D2CVE7;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Peptidase S8/S53 domain-containing protein {ECO:0000259|Pfam:PF00082};
GN   ORFNames=PV07_00671 {ECO:0000313|EMBL:KIW33855.1};
OS   Cladophialophora immunda.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC   Cladophialophora.
OX   NCBI_TaxID=569365 {ECO:0000313|EMBL:KIW33855.1, ECO:0000313|Proteomes:UP000054466};
RN   [1] {ECO:0000313|EMBL:KIW33855.1, ECO:0000313|Proteomes:UP000054466}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 83496 {ECO:0000313|EMBL:KIW33855.1,
RC   ECO:0000313|Proteomes:UP000054466};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA   Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Cladophialophora immunda CBS83496.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR   EMBL; KN847040; KIW33855.1; -; Genomic_DNA.
DR   RefSeq; XP_016254071.1; XM_016387143.1.
DR   AlphaFoldDB; A0A0D2CVE7; -.
DR   STRING; 569365.A0A0D2CVE7; -.
DR   GeneID; 27339865; -.
DR   VEuPathDB; FungiDB:PV07_00671; -.
DR   HOGENOM; CLU_312828_0_0_1; -.
DR   OrthoDB; 2247221at2759; -.
DR   Proteomes; UP000054466; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00306; Peptidases_S8_S53; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR   PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000054466};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT   DOMAIN          650..880
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   ACT_SITE        656
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        697
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        857
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   937 AA;  105664 MW;  D1610901E7A592E4 CRC64;
     MPAVFSTESG GRDKDFKPLM FDNFEAKIAS LSAVLHDFKQ VCRIFRSATR EGEQVAREFW
     TTLRSAVVIA QEHVSTLASS GSSSGGGVCA LVDRILDSLE NIFDDNNVGS RATALASSGT
     KRYSRLEIVH HHLHNVDSPN KSLVLLLSVQ DLLDSKKAHQ VKQSIEEWVD DLENLDDDQL
     EPILPPEQPP RINQLGNVSE LAQLTYTTLF GHLENLATCH KHQQHAAYAM LATYSELEED
     YEDFHFDLVF SVDGSQAYWE EVRVHSFRSD AQSGVRWARI GPESKRIKDW LLPRPMSVRQ
     ICHSLGKKDL SRSRRRNWLQ KSTQGSPMHE IWDHQPTNRQ FLPYEHYRLI SYADCLSNEV
     GPMVSFSKLV LAVILSYSLF YLCEGPWLPS RWPRHGIKFF RAGSTTFLRP LLYVPIFSGY
     PDTAQAYETY HQYPVLVGFA TTLLEIHQGR TLQSILDLTE DITDVDDEWA RACEAYDKCK
     KNISETQYKE VIEACLNARF ELQELCEGQE FQQQIFHKIV APLVTLLEEA FGNFSPMSDL
     DAQASRLDLS TGLLVTEVQK SQDAPRYTLY KIDRLDSSTN PILTARQGKA SASGTTSQTL
     VLSDSLYGEE EPLSESSAEC SHTDRWFDAL HAADSFRTLK RLSLDDTTRV RIAILDTGLD
     RNHGLVREHK ERIRAVCDWV DGDGSNDDDW SGDEVGHGTH IACIILANAP NADVFIARIS
     KTRALRHRHT LPVAKALQKA RDRWEVDIIN MSFGFRDASP IIDDELKKAI NQDILVFAAA
     SNAGGNLPRS YPAFRDQVFG IHSTDGRGNP SKFNPTPLKD GNFSTVGELI DSAWPSKDRM
     GSSAVSVFST RRMSGTSFAT PVAVSIVALL LDYFGQNMQD EVTILKMKEF NGMRRILALI
     SNERQGFNYM NPYTFLQQSQ EDIRRSIRNA LNMKTLS
//