ID   A0A0D2DCZ3_9EURO        Unreviewed;       849 AA.
AC   A0A0D2DCZ3;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Dimethylhistidine N-methyltransferase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=PV07_00404 {ECO:0000313|EMBL:KIW33564.1};
OS   Cladophialophora immunda.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC   Cladophialophora.
OX   NCBI_TaxID=569365 {ECO:0000313|EMBL:KIW33564.1, ECO:0000313|Proteomes:UP000054466};
RN   [1] {ECO:0000313|EMBL:KIW33564.1, ECO:0000313|Proteomes:UP000054466}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 83496 {ECO:0000313|EMBL:KIW33564.1,
RC   ECO:0000313|Proteomes:UP000054466};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA   Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Cladophialophora immunda CBS83496.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KN847040; KIW33564.1; -; Genomic_DNA.
DR   RefSeq; XP_016253780.1; XM_016386852.1.
DR   AlphaFoldDB; A0A0D2DCZ3; -.
DR   STRING; 569365.A0A0D2DCZ3; -.
DR   GeneID; 27339598; -.
DR   VEuPathDB; FungiDB:PV07_00404; -.
DR   OrthoDB; 1416at2759; -.
DR   Proteomes; UP000054466; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.1580.10; paralog of FGE (formylglycine-generating enzyme); 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR019257; MeTrfase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR017805; SAM_MeTrfase_EasF-type_put.
DR   InterPro; IPR005532; SUMF_dom.
DR   InterPro; IPR042095; SUMF_sf.
DR   NCBIfam; TIGR03439; methyl_EasF; 1.
DR   PANTHER; PTHR43397; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR   PANTHER; PTHR43397:SF1; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR   Pfam; PF03781; FGE-sulfatase; 2.
DR   Pfam; PF10017; Methyltransf_33; 1.
DR   SUPFAM; SSF56436; C-type lectin-like; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054466};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          35..329
FT                   /note="Histidine-specific methyltransferase SAM-dependent"
FT                   /evidence="ECO:0000259|Pfam:PF10017"
FT   DOMAIN          550..676
FT                   /note="Sulfatase-modifying factor enzyme"
FT                   /evidence="ECO:0000259|Pfam:PF03781"
FT   DOMAIN          747..845
FT                   /note="Sulfatase-modifying factor enzyme"
FT                   /evidence="ECO:0000259|Pfam:PF03781"
FT   REGION          706..729
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        706..728
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   849 AA;  96077 MW;  059171FC912C91A6 CRC64;
     MATHTPAGVP ILDIRSDQSD QSLLHTLKQS LNPPKGQPRT FPTLLLYDEK GLKLFEEITY
     VDEYYLTNAE IDTLTRHAGK IVGRIPDGAR LVELGSGNLR KVNILLKAFE EANKNVEYYA
     LDLSLSELKR TFAQLDINAF HHVTFRALHG TYDDALLWLK ESATDARTTC VMTMGSSLGN
     FTREEAAQFL ASFKKVLAAS DYVMVGIDAC QQPDRVFRAY NDSMNVTERF YRNGLTHANN
     ILGYEAFRQD EWQIEGVYDE NQNKHQASYV ALKTINNKDF SFEQGEKVHL EDAFKYSEAQ
     RDALWHAAGL IPQTAYNNKT NDYYIHLLSP STINFPTKPA EFAASPVPSL DDWRQLWAAW
     DTVTKSMVPK DELLNKPIKL RNDLIFYLGH IPTFADIHYM KATKEKATDP AYYMSIFERG
     IDPDVDNPEL CHDHSEIPDS WPPLEDILNY SQRVRERIVE GIHSGRAYTD RRLSRGLWLA
     YEHEAMHLET FLYMLLQSER VLPPPGEGLP DFRTLAAEAR ANRTSNQWHR IPASKVKIGL
     DDPENNFGPD RYFGWDNERP SRTVAVNEFE AQSRPISNGE YARFLEVTHK DSLPASWTAS
     KVGAVLNGTN GTNGANGHVQ DELDMASPSF VEDKAIRTVY GLIPLKYALD WPVMASYDEL
     AAYAEWSNGR IPTLEEARSL YQYVENQDSV LQKVTSKLIS AVNGHLSNDG VQETPPSTHQ
     SNGVVNGSAD GPSLDPNELF VELGDRNVAF RHWHPTPVTG NADRLRGQSD LGGLWEWTST
     PLAPHEGFKA MDLYPGYTAD FFDSKHNVCL GGSWATVPRI ALKKTFVNWY QRNYPYVWCT
     ARLVRDVVV
//