ID A0A0D2DEY4_9EURO Unreviewed; 962 AA.
AC A0A0D2DEY4;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 22-FEB-2023, entry version 30.
DE RecName: Full=ER membrane protein complex subunit 1 {ECO:0000256|ARBA:ARBA00020824};
GN ORFNames=Z517_11002 {ECO:0000313|EMBL:KIW76256.1};
OS Fonsecaea pedrosoi CBS 271.37.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442368 {ECO:0000313|EMBL:KIW76256.1, ECO:0000313|Proteomes:UP000053029};
RN [1] {ECO:0000313|EMBL:KIW76256.1, ECO:0000313|Proteomes:UP000053029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 271.37 {ECO:0000313|EMBL:KIW76256.1,
RC ECO:0000313|Proteomes:UP000053029};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea pedrosoi CBS 271.37.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Component of the ER membrane protein complex (EMC).
CC {ECO:0000256|ARBA:ARBA00011276}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the EMC1 family.
CC {ECO:0000256|ARBA:ARBA00007904}.
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DR EMBL; KN846975; KIW76256.1; -; Genomic_DNA.
DR RefSeq; XP_013280064.1; XM_013424610.1.
DR AlphaFoldDB; A0A0D2DEY4; -.
DR STRING; 1442368.A0A0D2DEY4; -.
DR GeneID; 25310492; -.
DR VEuPathDB; FungiDB:Z517_11002; -.
DR HOGENOM; CLU_005034_0_1_1; -.
DR OrthoDB; 37872at2759; -.
DR Proteomes; UP000053029; Unassembled WGS sequence.
DR GO; GO:0072546; C:EMC complex; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR026895; EMC1.
DR InterPro; IPR011678; EMC1_C.
DR InterPro; IPR002372; PQQ_repeat.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR21573:SF0; ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1; 1.
DR PANTHER; PTHR21573; UNCHARACTERIZED; 1.
DR Pfam; PF07774; EMC1_C; 1.
DR Pfam; PF13360; PQQ_2; 2.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053029};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..962
FT /note="ER membrane protein complex subunit 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002240507"
FT TRANSMEM 934..952
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 740..961
FT /note="ER membrane protein complex subunit 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07774"
SQ SEQUENCE 962 AA; 104022 MW; 159AF1A1F5D13C5A CRC64;
MKWYGVASIL PSLFWPACAI FADDAFHIDF HHALIGSPQP HTTFFHKPHS NTNASLLYTL
SDKAVLGAVN PKDGSALWRQ PLAGQPIDNA SSLYLIAGER DGQLISGYDR TVACWDALDG
RLVWDYTLPP GTVIGGLQAI PLQGSVADGV PQDFVVLAVS TDSQTHTSIS RIAGDGGGQR
WQHVDSSTAH GSSASIATSA QHVYYITTSH GLLTSSKAKV ITLDSATGHE VSQTGVAVDT
EPLAPGGQYV ADACSGSPFL ISAEKPFKAV KFSLLSHPKG SSLTLDDKGE EIEDVTIHAA
CHQSRATHFL LHIKGKTRQW AEVFHVNPKS GDVTKVYSLP ATEEQSVFSA SSYEGSAFFI
RSTESEVLLY SSESHGQLGR WRKTNFKTSP GSFHSHATAE VVSRGKANYA VRVAEFSNSG
DWSLIRNGEL QWSRPEMLAY ANIAAWDENG APDALAEELD LESSVNPWTA YLHRLKRHIH
DLASLPEYLR NLPDTILKST PDADVITRQN LVGTKVVIVA TTRKEVIALD ATTPGVLRWQ
SDLSSYIPEG TEIKSITVSG GRVSVYLSKG SLLVLNTNNG SLIENKPGTI AISHLIQIPG
SPAPAVIKVG YDGVPRFAED VVPGTVSEGN TVVTISPDGK AIGWTVGRNI EKTWTLNPQD
GMKIVRAVAR AEHDPVASIG RVLGNRSVLY KYLSPNVALL LSTSQSGALT VYLIDAVTGA
ILHTATHHGV LYSDKPAVIS ENWYAYTFTV RDPLTSGLSN QLVISELYES STPNDRGLLA
ARTNYSVFSV DGAAAKPYVI SQSYTVAEPI SHLTVSQTAQ GIASRQLLAT LPNSNAIVGI
PREILDPRRP VERDPNATER EEGLTRYMPI LEFDPKYYLT HSREVLGIKE VLSSPTLLES
TSRVFAFGHD IFDTTITPSL AFDVLGKGFN RVQLVLTVVA LFAGVGALRP LVRKKTVDGR
WR
//
