ID A0A0D2DFW4_9EURO Unreviewed; 1070 AA.
AC A0A0D2DFW4;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Rad4 beta-hairpin domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=Z517_09025 {ECO:0000313|EMBL:KIW76581.1};
OS Fonsecaea pedrosoi CBS 271.37.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442368 {ECO:0000313|EMBL:KIW76581.1, ECO:0000313|Proteomes:UP000053029};
RN [1] {ECO:0000313|EMBL:KIW76581.1, ECO:0000313|Proteomes:UP000053029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 271.37 {ECO:0000313|EMBL:KIW76581.1,
RC ECO:0000313|Proteomes:UP000053029};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea pedrosoi CBS 271.37.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KN846974; KIW76581.1; -; Genomic_DNA.
DR RefSeq; XP_013280389.1; XM_013424935.1.
DR AlphaFoldDB; A0A0D2DFW4; -.
DR STRING; 1442368.A0A0D2DFW4; -.
DR GeneID; 25308515; -.
DR VEuPathDB; FungiDB:Z517_09025; -.
DR HOGENOM; CLU_003639_1_1_1; -.
DR OrthoDB; 181129at2759; -.
DR Proteomes; UP000053029; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.60.290; Rad4, beta-hairpin domain BHD2; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135:SF3; DNA REPAIR PROTEIN RAD4; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053029}.
FT DOMAIN 480..538
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 540..603
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 610..684
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 43..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 987..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..575
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1045
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1070 AA; 117843 MW; E8B4CDBBB94EA925 CRC64;
MPRRTSRPAA RSTRATRQSA RQPQKTEDDI PEVYGDMLAE AVAQEQASAS DPRATKRRKI
SDEPAAEISL DFDLFGSSTH VQGIDNTRSA DDAPPKLQQV VFDDFEVSDE SDAEFEDVDL
EAAANDVVDD QQLEQKTLEL DLSKNSTPRR SIQRRKPVGL AERRLRLDAH KAHLVLLLAH
LNCRNKWCNS ESVQSVLKPL VPRKVISLLH VDESKPQYQR SHSFNKGIEE VCAIWRQQWN
TTARGMKRAF WRDDIDVVKE SDDAEDLIDF DDFKAAAVSR SGSRDLGAQL FCTLLRSVAV
DVRLVCSLQV LPFSAIAKGQ TPEKPKPQYI YAPPQTFSSA AKDTDVTTRV ARTPNPKKRK
IVESPFPIFW VEVFSPSIQT WIPLDPLVRN TINKPKTGFE PPASDQLNSM TYVVAFEDDE
SARDVTRRYT QWYNAKTRKQ RVESTKGGEK WWEVTMNVFQ RPFSETRDEI EDASLLKRAE
SEPMPKNMQD FRGHPVYVLE RHLRLNEVIH PRHEVGKVSA GPSKSAKLES VFRRRNVHVC
RTADAWYRRG RDVKQGEQPL KRVVPKRQRN QDGPSTEDME DEDQGIQGMA LYAEYQTSLY
EPPPVVDEKI PRNAYGNLDV YVPSMIPAGA VHIRHPLASA AARVLGIDYA DAVTGFQFKG
RQGTAVVDGV VVSMNMTNAM INVIEGLESQ ATEEVQEART RIILAMWKRW LTALRVHEHV
HRQYGDRSHG TKGDAGGAAQ VTVSRDEEDG GGFMMDQADL DEREASVDTV PLTTPNLKPL
NQLLPPEVVH QDVIVVRSPN KLTRLPSPVR TRSHDRIVGE PPNATNSGGL FLDAEDAGGG
FVSEDGLSLH PPASQRHERA VSQDGKLTND EAGGFIAEED NEGGGFLAED EEADTESHRR
SVTGHGDPIQ AAETAEMLFE THYASSTEKL NETGAGNATA AAAGDSSAEP RSISTGEGGG
RREDPAISTC SVQIPDADDV ALCGQPRSIN ATLDPPHPSL GSGETTAGED KGGEGGEEEG
QARGPRGQTS RSGSGSGSAS ASVAGSLLSH DPEEDDAEPE WLLSSLGELD
//
