ID A0A0D2DIY6_9EURO Unreviewed; 1321 AA.
AC A0A0D2DIY6;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=ABC multidrug transporter SitT {ECO:0008006|Google:ProtNLM};
GN ORFNames=Z517_10057 {ECO:0000313|EMBL:KIW77611.1};
OS Fonsecaea pedrosoi CBS 271.37.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442368 {ECO:0000313|EMBL:KIW77611.1, ECO:0000313|Proteomes:UP000053029};
RN [1] {ECO:0000313|EMBL:KIW77611.1, ECO:0000313|Proteomes:UP000053029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 271.37 {ECO:0000313|EMBL:KIW77611.1,
RC ECO:0000313|Proteomes:UP000053029};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea pedrosoi CBS 271.37.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KN846974; KIW77611.1; -; Genomic_DNA.
DR RefSeq; XP_013281419.1; XM_013425965.1.
DR AlphaFoldDB; A0A0D2DIY6; -.
DR STRING; 1442368.A0A0D2DIY6; -.
DR GeneID; 25309547; -.
DR VEuPathDB; FungiDB:Z517_10057; -.
DR HOGENOM; CLU_000604_17_2_1; -.
DR OrthoDB; 1067095at2759; -.
DR Proteomes; UP000053029; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18577; ABC_6TM_Pgp_ABCB1_D1_like; 1.
DR CDD; cd18578; ABC_6TM_Pgp_ABCB1_D2_like; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221:SF219; ABC MULTIDRUG TRANSPORTER (EUROFUNG); 1.
DR PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053029};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 728..753
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 773..801
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 844..867
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 873..896
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 958..980
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 992..1014
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..328
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 363..642
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 732..1020
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1077..1316
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 650..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1321 AA; 143043 MW; BD1FB36A8C26E090 CRC64;
MNLFQKLVGY PRLLLAGSPS KIDAGMLLLA ILSAIASGIP FPLIGILFGQ LIDDFNSATC
DSPDTSSARS QHQHSINDKI LLILYLAIAQ FVTIYMHLSC WTLNGARLAQ RLRESYLHNL
LRQEPSYFDN LPPGEVASRL NGDIQAIRSG TSEKVGICLS SLSFFITAYI VAFIKDYKLA
AMLVSLIPAY FLMSFVGSHY VEKYSGMMSD YAATAASIAS EALSNVVVVH AFGANTRLED
KFAKALKASE HEGLKKALAV GVQSGVLYFI AYSANGLAFW QASQRIADAV RHDATAASVG
VTFTVVFILI EATLVLSQVA PFLHLFGAAV ASFQKLREDM DREPLIDGTA ASGFPLSQAE
GGFEFQGVSF NYPSRPEVTV LDQINLRIPP RKHTAIVGFS GSGKSTIAGL LTRLYDPTQG
QVLFDGHNLR DLNLHDLRSF LSLVQQDPSL LDRSILENIA HGLINSSHSS HTHLKATLLG
PDLANLARQV REGQDLNAAA EKLGSNVVEI ISLVRNAAEL ADADSFIVAL QHGYGTVVGS
SGRLISGGQK QRVALARALV KDPAVLILDE ATASLDSRSE QRIQRAISGI ASGRTMITIA
HRLSTITGAD NIIVMQKGRI LEEGSHSTLM AKNGAYADLV RLQTLGSTSE KNVTADSTRQ
SDYGSSNKGA TGESTLSIDG IGTVEKTEIS ASQDEVNESV EEQEEPETPS KSLWSLLRGF
APVLRPHLLI IIISLFASSV VGGSFSAEAV IFGNTVGSLS PCQSESYIRS RGSFLGLMFF
ILAIIEFFAN VTSWTGFGWV AEKTVRSVRV LSFRSLFGQD LQWHQSEGRT PALLLSYITR
DGNALSGLSG SVIGTLFSIT VNLIVAIVLT HIIAWRIALV CLSLVPLLLG AGLMELRVLA
RFEERHENAY TKSVDIGVEA ITSIKTIASL SLEEETLGTY RRSLKGPRKE TLKVSLHASL
WQAMTYLLGN LVNALAYWWG SKQIIAGNYT QTQFMIVVFS LLVSALLWSQ MFALAPELTS
ARAAVARLLG LIEIGPDRTQ GRVKGTPSLN LCFEDKDLEK TAEAKPTLPP SNQGSSVQLC
DVHFAYPSRP EVEVLKGLNV DIRPGTLCAL VGPSGAGKST IISLVERLYT PRSGSVIVDG
LDVTKTRDVS FRDTIALVPQ ESVLFEGTIE FNIGLGARPD HEASMDEIQE ACKLANIHDT
IQSLPNGYQT LCGPNGNQFS GGQKQRLSIA RALVRKPKLL ILDEPTSALD AESEKLLQDG
LEKASRGITV IAIAHRLHTI RKADVIFLIE GGQCVDRGTH EELLQRSESY RLNVMHQTLA
E
//
