ID A0A0D2DJ33_9EURO Unreviewed; 337 AA.
AC A0A0D2DJ33;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=4-hydroxy-2-oxoglutarate aldolase, mitochondrial {ECO:0008006|Google:ProtNLM};
GN ORFNames=Z517_07498 {ECO:0000313|EMBL:KIW77666.1};
OS Fonsecaea pedrosoi CBS 271.37.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442368 {ECO:0000313|EMBL:KIW77666.1, ECO:0000313|Proteomes:UP000053029};
RN [1] {ECO:0000313|EMBL:KIW77666.1, ECO:0000313|Proteomes:UP000053029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 271.37 {ECO:0000313|EMBL:KIW77666.1,
RC ECO:0000313|Proteomes:UP000053029};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea pedrosoi CBS 271.37.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
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DR EMBL; KN846973; KIW77666.1; -; Genomic_DNA.
DR RefSeq; XP_013281474.1; XM_013426020.1.
DR AlphaFoldDB; A0A0D2DJ33; -.
DR STRING; 1442368.A0A0D2DJ33; -.
DR GeneID; 25306988; -.
DR VEuPathDB; FungiDB:Z517_07498; -.
DR HOGENOM; CLU_049343_0_2_1; -.
DR OrthoDB; 1780992at2759; -.
DR Proteomes; UP000053029; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR PANTHER; PTHR12128:SF47; DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G01230); 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|PIRNR:PIRNR001365};
KW Reference proteome {ECO:0000313|Proteomes:UP000053029}.
FT ACT_SITE 157
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 187
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 230
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 337 AA; 36147 MW; 122C715E4118868C CRC64;
MALQQVHNSN DQAEASGYPT APPAGCYVPA VTFFDPETDR ICLDAQAKYY SYLASTGLTG
LVILGTNAET FLLTREERMT LLQLARRSVP EGYPIIAGTS GHSTAQVLEF ITDAYNAGAN
YVLVLPCAYF GKQTTPAVVK RFYKEVAASS PLPILIYNFP AVCNGLDLDA NIITDIARES
RNIVGVKLTC GSVAKITCLG SRFPATRFAV FGGQSDFLVG GLASGSTGCI GAFCNVFPKV
VAKIYDLWSS GQYSEALALQ KLVASAETAT KAGIANTKYA AAIFTAPKAG IADAVRLLKP
RRPYEEPTDT VKRSIQTVME ALNREEKEIS VKPQSRL
//