ID A0A0D2DJT4_9EURO Unreviewed; 1231 AA.
AC A0A0D2DJT4;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=PV04_10799 {ECO:0000313|EMBL:KIW62642.1};
OS Phialophora macrospora.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Phialophora.
OX NCBI_TaxID=1851006 {ECO:0000313|EMBL:KIW62642.1, ECO:0000313|Proteomes:UP000054266};
RN [1] {ECO:0000313|EMBL:KIW62642.1, ECO:0000313|Proteomes:UP000054266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 27337 {ECO:0000313|EMBL:KIW62642.1,
RC ECO:0000313|Proteomes:UP000054266};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capronia semiimmersa CBS27337.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN846963; KIW62642.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D2DJT4; -.
DR STRING; 5601.A0A0D2DJT4; -.
DR HOGENOM; CLU_002173_5_1_1; -.
DR OrthoDB; 5471864at2759; -.
DR Proteomes; UP000054266; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 870..1231
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..53
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..449
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1199
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1231 AA; 138398 MW; 374D8FAE63FD8FCD CRC64;
MASLPSSASH HHHFGRPRPR NPQLTRSASH DQPPPTADLN RPLPPPPPPP LATAAAETYE
IPTLRRKPVP DELPDPGAAK LNHSRSFSHP FPSIFGSRKS EKKNKHGGDF DGTRDSRHDE
VGSKHPAAES SSFRDDRQPV TGRCMTCDST VRWPQGLKVF RCTTCLTIND LEFNPDKRPD
TQGPAIGPAP QRKILPLSVE RTRSLLDRCL TQYLESRVGR DEPVTPAHPV PVENDSLADD
SFLVDGSPPE GILYNQLADE QESPPPSPLP RVNPRSPSEE STLSTHHSGR NAGPPFVQDH
SIDPFSSATS LSVRPRDARA RQPSEPGPTT SPNPGPRWDI FYLVEDYIAG CFVGCAALNH
SFLTPRPPQE PNPKPRSSSG TRQRRQLSET ISAPSFDNDV FLSELDAKTL LLGDVAENGS
WWLGAPSGRM TTGKDVNHQR DKSPDKNRSI ASARHHRINW LELAEWYRLI IYAGDLWEER
WHELLPKLSD ARAQQCWRST PLENIQRDII ESRIHLQRSL LKVSENLLKR PRQPLKHPED
CRFLLILLAN PLLTPARLEA GKMFGTTMPH PPIPPARLQV DGKARDSPSK RIPSSGRRPG
SLGHHSGIIK RILGLMANLS NENHQYLVSW FSRYADGHFQ RTVEMVGSFV SYRLSRQQKN
PTHEPVNPTE GLVPSFSDAG THHASQIHAA LGGYRPASTA AGKSQEKPRL SAYGEDWQIR
VAARVMALLF QANVGHVARK RDASAAHEQR LHSPGLNAKY RAYLHGQIVP ISNFYNTMLD
YADLVADFET WENTKTKFTF CQYPFFLSIY AKIHILEHDA RRQMEVKARE AFFDSILSRR
AVSQYLILKV RRDCLVEDSL RGVSEVVGSG GSDIKKGLRI DFQGEEGVDA GGLRKEWFLL
LTREIFDPYH GLFVYDDDSQ YCYFNPFCFE SSEQFFLVGV LLGLAIYNST ILDVSFPPFV
FKKMLASAPS TGDKLTSTPK VPHGYTLEDL AELRPLLAKG LRHLLEFEGD VEETFCRDFV
AEMDRYGEIV QIPLCPGGEK RAVTNSNRRE FVDLYVHYLL DTAVARQYEP FKRGFFTVCG
GNALSLFRPE EIELLVRGSD EPLDIASLRA VATYEGWPKA DGPPEQQPQV IWFWEFFARV
SPTDQRKILS FITASDRIPA MGAANLVIKI QLIREREEVD SVGTPTNKPI ERFPIARTCF
NTLSLYRYAS RQKLEEKLWM AVQCSEGFGL K
//
